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Development of new cancer therapy using the exosomes from patients.

Research Project

Project/Area Number 24659166
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeSingle-year Grants
Research Field Human pathology
Research InstitutionTokyo Medical University

Principal Investigator

NAKAYA Takeo  東京医科大学, 医学部, 助教 (80512277)

Co-Investigator(Kenkyū-buntansha) KURODA Masahiko  東京医科大学, 医学部, 教授 (80251304)
Project Period (FY) 2012-04-01 – 2014-03-31
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywordsがん / エキソソーム / miRNA / CD8 T細胞 / 腫瘍抑制 / microRNA / T細胞 / がん治療開発
Research Abstract

We developed the effective culture system of human CD8 T cells and effective collection methods of CD8 T cell generating exosomes. We also invented the accurate measurement system of T cell exosomes using the surface molecules of CD8 T cells. We also developed the cancer cell targeting exosomes. We investigated the tumor suppressive effects of cancer cell targeting exosomes in mice with human lung cancer cells or sarcoma cells. We observed how the miRNA including exosomes suppress the luciferase expression in luciferase expressing mice. We also investigated the methods that only hepatic cells can intake exosomes using HBV derived surface molecules.

Report

(3 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • Research Products

    (1 results)

All 2012

All Book (1 results)

  • [Book] 化学2012

    • Author(s)
      仲矢丈雄,黒田雅彦,大木忠明
    • Total Pages
      5
    • Publisher
      化学同人
    • Related Report
      2012 Research-status Report

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Published: 2013-05-31   Modified: 2019-07-29  

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