Visualizing of caspase-1 activation upon bacterial infection
| Project/Area Number |
24659201
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Bacteriology (including Mycology)
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| Research Institution | University of the Ryukyus |
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Principal Investigator |
SUZUKI Toshihiko 琉球大学, 医学(系)研究科(研究院), 教授 (10292848)
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 炎症 / カスパーゼ-1 / イメージング |
|---|
| Research Abstract |
The antibodies specifically reacting the cleaved caspase-1 and cytokines are useful tools for analysis of the activation of innate immune responses. However, only a few antibodies have been developed for using against human cells, and no antibody for mouse. We developed specific antibodies which are capable to specifically react mouse cleaved caspase-1, cleaved IL-1beta and cleaved IL-18. The successful developed antibodies can recognize the cleaved form but not inactive proform.
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Report
(3 results)
Research Products
(34 results)
