| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Research Abstract |
The antibodies specifically reacting the cleaved caspase-1 and cytokines are useful tools for analysis of the activation of innate immune responses. However, only a few antibodies have been developed for using against human cells, and no antibody for mouse. We developed specific antibodies which are capable to specifically react mouse cleaved caspase-1, cleaved IL-1beta and cleaved IL-18. The successful developed antibodies can recognize the cleaved form but not inactive proform.
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