Study on the infection and proliferation of HCV during hepatic differentiation of human hepatic stem cells
| Project/Area Number |
24659205
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Virology
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| Research Institution | Kyoto University |
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Principal Investigator |
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | ウイルス / 肝炎 / 肝幹細胞 / 肝分化 / 自然免疫 / インターフェロン / C型肝炎ウイルス / ヒト肝細胞 / 幹細胞 / 肝細胞分化 / ウイルス感染 |
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| Research Abstract |
The aim of this study was to reveal the developmental stage of human hepatocytes permissive to the infection and proliferation of HCV, using human hepatic stem cells that originally established by our laboratory. Infection experiment of HCV using the hepatic stem cells after induction of hepatic differentiation suggested that the highly matured hepattocytes are required for efficient infection of HCV. Our results also suggested the requirement of suppression of innate immune system of the cells to establish efficient HCV culture system.
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Report
(3 results)
Research Products
(10 results)
