Does urinary Megalin become the index of acute renal disease in the renal tissue blood circulation disorder?
| Project/Area Number |
24659270
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Laboratory medicine
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| Research Institution | Niigata University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
SAITOH Akihiko 新潟大学, 医歯学系, 特任教授 (80293207)
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 尿中バイオマーカー / メガリン / 急性腎障害 / 体外循環 / 心臓血管外科 / AKI / AKD / 人工心肺 |
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| Research Abstract |
We measured perioperative urinary biomarkers of the cardiac surgery and considered usefulness for early detection of acute kidney injury (AKI). As known biomarker, low molecular protein (albumin, arufa-1 microglobulin and beta-2 microblobulin) and cell injury marker (NAG and NGAL), as new biomarker megalin in which reabsorb many kinds of protein at proximal tubular cell were measured. Arufa-1 microglobulin, NAG and NGAL were significantly high score in AKI group but low specificity. It is expected for new marker which has higher specificity for AKI or the protocol of diagnosis AKI with the combination of plural markers. Megalin were not measured completed, it will need to consider in the suture. This study also revealed that plural markers were different changes and value between adult and infants.
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Report
(3 results)
Research Products
(12 results)
