A case-control study on breast cancer with special reference to equol productivity and intestinal bacteria NATTS.

• Project/Area Number: 24659325
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Public health/Health science
• Research Institution: Sapporo Medical University
• Principal Investigator: MORI Mitsuru 札幌医科大学, 医学部, 教授 (50175634)
• Co-Investigator(Kenkyū-buntansha): KUTOMI Goro 札幌医科大学, 医学部, 講師 (10404625) ; HIRATA Koichi 札幌医科大学, 医学部, 教授 (50136959)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000); Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
• Keywords: 乳がん / アディポネクチン / インスリン / BMI / 症例対照研究 / breast cancer / case-control study / adiponectin / obesity / insulin / イソフラボン / エコール

Outline of Final Research Achievements

Obesity-related risk factors including serum adiponectin and insulin levels have been analyzed together with BMI in association with breast cancer risk. Methods: We measured serum high molecular weight (HMW) adiponectin and insulin levels in a hospital based case-control study, including 66 sets of female breast cancer cases and age and menopausal status matched controls. Serum levels of HMW adiponectin, insulin levels and body mass index (BMI) were examined in association with breast cancer risk with adjustment for the various known risk factors by menopausal status. Results: Women in the highest HMW adiponectin levels showed significant reduced risk of breast cancer in both pre and postmenopausal women. Lower BMI showed decreased breast cancer risk in both pre and postmenopausal women. Conclusions: These results indicated that higher serum HMW adiponectin levels and lower BMI are associated with a decreased breast cancer risk in both pre and postmenopausal women in Japan.

Research Products

• [Journal Article] Relation of serum adiponectin levels and obesity with breast cancer: a Japanese case-control study. (2014)
  • Author(s): Minatoya M, Kutomi G, Shima H, Asakura S, Otokozawa S, Ohnishi H, Akasaka H, Miura T, Mori M, Hirata K.
  • Journal Title: Asian Pacific J Cancer Prev Volume: 15 Issue: 19 Pages: 8325-8330
  • DOI: 10.7314/apjcp.2014.15.19.8325
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Relationship of serum isoflavones, insuline and adiponectin levels with breast cancer risk. (2014)
  • Author(s): Minatoya M, Kutomi G, Asakura S, Otokozawa S, Sugiyama Y, Ohnishi H, Akasaka H, Miura T, Mori M, Hirata K.
  • Journal Title: Breast Cancer Volume: 21 Issue: 5 Pages: 452-461
  • DOI: 10.1007/s12282-013-0502-2
  • Peer Reviewed
• [Journal Article] Equol, adiponectin, insulin levels and risk of breast cancer. (2013)
  • Author(s): Minatoya M, Mori M, Kutomi G, Hirata K, et al.
  • Journal Title: Asian Pacific Journal of Cancer Prevention Volume: 14
  • Peer Reviewed