Impact of susceptible genes and stresss on endophenotype of irritable bowel syndrome

• Project/Area Number: 24659344
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: General internal medicine (including Psychosomatic medicine)
• Research Institution: Tohoku University
• Principal Investigator: FUKUDO Shin 東北大学, 医学(系)研究科(研究院), 教授 (80199249)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000); Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
• Keywords: 脳腸相関 / 過敏性腸症候群 / 遺伝子 / ストレス / 炎症 / 消化管運動 / 消化管知覚 / 神経伝達物質 / バイオマーカー

Outline of Final Research Achievements

Patients with irritable bowel syndrome (IBS) are characterized with exaggerated response to psychosocial stressors. We previously reported exaggerated colonic motility in IBS patients in response to administration of corticotropin-releasing hormone (CRH) which is one of key mediators of stress response. This study aimed to test the hypothesis that IBS and its phenotypes are associated with candidate genotypes and stress. Several candidate genes including CRH and allied molecules with association to IBS and its phenotypes were analyzed. As results, CRH receptor 1 genotypes and its haplotype were associated with IBS phenotype and bowel pattern. These results suggest that psychosocial stress may affect on the phenotype and endophenotypes of IBS.

Research Products

• [Journal Article] Evidence-based clinical practice guidelines for irritable bowel syndrome. (2015)
  • Author(s): Fukudo S, Kaneko H, Akiho H, Inamori M, Endo Y, Okumura T, Kanazawa M, Kamiya T, Sato K, Chiba T, Furuta K, Yamato S, Arakawa T, Fujiyama Y, Azuma T, Fujimoto K, Mine T, Miura S, Kinoshita Y, Sugano K, Shimosegawa T.
  • Journal Title: J Gastroenterol Volume: 50 Issue: 1 Pages: 11-30
  • DOI: 10.1007/s00535-014-1017-0
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Preceding stimulation affects brain activation in response to colonic distention in humans. (2013)
  • Author(s): Hamaguchi T, Kano M, Kanazawa M, Itoh M, Yanai K, Fukudo S.
  • Journal Title: Psychosom Med Volume: 75 Issue: 5 Pages: 453-462
  • DOI: 10.1097/psy.0b013e3182926682
  • Peer Reviewed
• [Journal Article] Serotonin transporter gene promoter polymorphism and alexithymia (2012)
  • Author(s): Kano M, Kanazawa M, et al
  • Journal Title: Neuropsychobiology Volume: 65 Issue: 2 Pages: 76-82
  • DOI: 10.1159/000329554
  • Peer Reviewed
• [Journal Article] Corticotropin-releasing hormone receptor 1 gene variants in irritable bowel syndrome (2012)
  • Author(s): Sato N, Suzuki N, Sasaki A, Aizawa E, Obayashi T, Kanazawa M, Mizuno T, Kano M, Aoki M, Fukudo S
  • Journal Title: PLoS One Volume: 7(9) Issue: 9 Pages: e42450-e42450
  • DOI: 10.1371/journal.pone.0042450
  • Peer Reviewed
• [Journal Article] Effects of personality traits on the manifestations of irritable bowel syndrome. (2012)
  • Author(s): Tayama J, Nakaya N, Hamaguchi T, Tomiie T, Shinozaki M, Saigo T, Shirabe S, Fukudo S.
  • Journal Title: Biopsychosoc Med. Volume: 6(1) Issue: 1 Pages: 20-20
  • DOI: 10.1186/1751-0759-6-20
  • Peer Reviewed
• [Presentation] Irritable Bowel Syndrome: Multimodal Disorder of Brain-Gut Interactions. (2014)
  • Author(s): Fukudo S
  • Organizer: Invited Lecture of Catholic University of Leuven
  • Place of Presentation: Leuven, Belgium
  • Year and Date: 2014-09-14 – 2014-09-17
  • Invited
• [Presentation] Effects of ramosetron on male patients with irritable bowel syndrome with diarrhea: randomized, placebo-controlled trial. (2013)
  • Author(s): Fukudo S, Ida M, Akiho H, Nakashima Y, Matsueda K.
  • Organizer: The 114th Annual Meeting of American Gastroenterological Association
  • Place of Presentation: Orlando, USA
  • Invited
• [Presentation] Pathophysiological and therapeutic approach from the east. IBD & IBS 2012: AGA-JSGE Joint Symposium. Part 2: Basic and clinical linkage of irritable bowel syndrome (IBS). (2012)
  • Author(s): Fukudo S.
  • Organizer: The 113th Annual Meeting of American Gastroenterological Association.
  • Place of Presentation: San Diego, USA
  • Invited
• [Book] Functional and GI Motility Disorders. (2014)
  • Author(s): Fukudo S, Machida T, Endo Y, Shoji T, Kano M, Kanazawa M
  • Total Pages: 176
  • Publisher: Karger, Basel, Switzerland
• [Book] When and how should we study colonic motility? In; Quigley EMM, Hongo M, Fukudo S (eds): Functional and GI Motility Disorders. Frontiers of Gastrointestinal Research. (DOI: 10.1159/000356745) (2014)
  • Author(s): Fukudo S, Machida T, Endo Y, Shoji T, Kano M, Kanazawa M.
  • Publisher: Karger, Basel, Switzerland
• [Book] 内臓感覚と不安・抑うつ. 久保木富房, 久保千春, 野村忍, 不安・抑うつ研究会 編. 心身相関医学の最新知識. (2012)
  • Author(s): 福土 審
  • Publisher: 日本評論社
• [Remarks] 東北大学病院心療内科
  • URL: http://www.hosp.tohoku.ac.jp/sinryou/s8_sinryou.html
• [Remarks] 東北大学病院心療内科
  • URL: http://www.hosp.tohoku.ac.jp/sinryou/s08_sinryou.html
• [Remarks] 東北大心療内科
  • URL: http://www.hosp.tohoku.ac.jp/sinryou/s08_sinryou.html