| Project/Area Number |
24659373
|
|---|
| Research Category |
Grant-in-Aid for Challenging Exploratory Research
|
| Allocation Type | Single-year Grants |
|---|
| Research Field |
Gastroenterology
|
|---|
| Research Institution | Institute of Physical and Chemical Research |
|---|
Principal Investigator |
MORO Kazuyo 独立行政法人理化学研究所, 統合生命医科学研究センター, 上級研究員 (90468489)
|
|---|
| Project Period (FY) |
2012-04-01 – 2014-03-31
|
| Project Status |
Completed (Fiscal Year 2013)
|
| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
|
|---|
| Keywords | ナチュラルヘルパー細胞 / ILC2 / IBD / NH細胞 / アレルギー / Th2サイトカイン / 寄生虫感染 / IL-25 / IL-33 |
|---|
| Research Abstract |
Inflammatory Bowel Diseases (IBD) is associated with chronic or recurring immune response and inflammation of the gastrointestinal tract. Prevalence rate of IBD reaching up to 396/100,000 persons (WHO), and two most common IBD are ulcerative colitis (UC) and Crohn's disease (CD). IL-33, an epithelial cell-derived cytokine, has been reported to increase in UC patients. Natural Helper (NH) cell, a new member of innate immune system, produces large amounts of IL-5 and IL-13 in response to IL-33, and induces eosinophilia and goblet cell hyperplasia. In this study, we examined the distribution of NH cells in the intestine and the role of NH cells in dextran sodium sulfate (DSS)-induced colitis model mouse.
|
