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Role of Natural Helper cells in imflammatory bowel disease.

Research Project

Project/Area Number 24659373
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeSingle-year Grants
Research Field Gastroenterology
Research InstitutionInstitute of Physical and Chemical Research

Principal Investigator

MORO Kazuyo  独立行政法人理化学研究所, 統合生命医科学研究センター, 上級研究員 (90468489)

Project Period (FY) 2012-04-01 – 2014-03-31
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywordsナチュラルヘルパー細胞 / ILC2 / IBD / NH細胞 / アレルギー / Th2サイトカイン / 寄生虫感染 / IL-25 / IL-33
Research Abstract

Inflammatory Bowel Diseases (IBD) is associated with chronic or recurring immune response and inflammation of the gastrointestinal tract. Prevalence rate of IBD reaching up to 396/100,000 persons (WHO), and two most common IBD are ulcerative colitis (UC) and Crohn's disease (CD). IL-33, an epithelial cell-derived cytokine, has been reported to increase in UC patients. Natural Helper (NH) cell, a new member of innate immune system, produces large amounts of IL-5 and IL-13 in response to IL-33, and induces eosinophilia and goblet cell hyperplasia. In this study, we examined the distribution of NH cells in the intestine and the role of NH cells in dextran sodium sulfate (DSS)-induced colitis model mouse.

Report

(3 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • Research Products

    (41 results)

All 2014 2013 2012 Other

All Journal Article (6 results) (of which Peer Reviewed: 5 results,  Open Access: 1 results) Presentation (31 results) (of which Invited: 9 results) Book (1 results) Remarks (3 results)

  • [Journal Article] An atlas of active enhancers across human cell types and tissues.2014

    • Author(s)
      Anderson R, Gebhard C, Miguel-Escalada I, Hoof I, Bornholdt J, Boyd M, Chen Y, Zhao X, Schmidl C, Suzuki T, Collaborators(261) Enomoto H, etc.
    • Journal Title

      Nature

      Volume: 507 Issue: 7493 Pages: 455-461

    • DOI

      10.1038/nature12787

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Critical role of p38 and GATA3 in natural helper cell function.2013

    • Author(s)
      Kabata H, Moro K, Fukunaga K, Suzuki Y, Miyata J, Masaki K, Betsuyaku T, Koyasu S, Asano K.
    • Journal Title

      Nat Commun.

      Volume: 4 Issue: 1 Pages: 2675-2675

    • DOI

      10.1038/ncomms3675

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Critical role of p38 and GATA3 in natural helper cell function.2013

    • Author(s)
      Furusawa J, Moro K, Motomura Y, Okamoto K, Zhu J, Takayanagi H, Kubo M, Koyasu S.
    • Journal Title

      J Immunol.

      Volume: 191 Issue: 4 Pages: 1818-26

    • DOI

      10.4049/jimmunol.1300379

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Stress-induced production of chemokines by hair follicles regulates the trafficking of dendritic cells in skin.2012

    • Author(s)
      Keisuke Nagao
    • Journal Title

      Nature Immunology

      Volume: 13(8) Issue: 8 Pages: 744-752

    • DOI

      10.1038/ni.2353

    • Related Report
      2013 Final Research Report 2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Role of innate lymphocytes in infection and inflammation.2012

    • Author(s)
      Koyasu S., Moro K.
    • Journal Title

      Front Immunol

      Volume: 3 Pages: 101-101

    • DOI

      10.3389/fimmu.2012.00101

    • Related Report
      2013 Final Research Report 2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Natural "Helper" Cells in the Lung : Good or Bad Help?2012

    • Author(s)
      Shigeo Koyasu, Kazuyo Moro
    • Journal Title

      Immunity

      Volume: 36(23) Issue: 3 Pages: 317-319

    • DOI

      10.1016/j.immuni.2012.03.001

    • Related Report
      2012 Research-status Report
  • [Presentation] ナチュラルヘルパー細胞とアレルギー疾患2014

    • Author(s)
      茂呂和世
    • Organizer
      2th Academy of Aging and Cardiovascular- Diabetes Research
    • Place of Presentation
      東京
    • Year and Date
      2014-01-11
    • Related Report
      2013 Annual Research Report 2013 Final Research Report
  • [Presentation] Natural Helper Cell~ a new player in innate immune system~2013

    • Author(s)
      Kazuyo Moro
    • Organizer
      Annual Meeting of The Japanese Society for Immunology
    • Place of Presentation
      千葉
    • Year and Date
      2013-12-22
    • Related Report
      2013 Final Research Report
  • [Presentation] Th2型疾患におけるナチュラルヘルパー細胞の役割2013

    • Author(s)
      茂呂和世
    • Organizer
      第43回日本皮膚アレルギー・接触皮膚炎学会総会学術大会
    • Place of Presentation
      金沢
    • Year and Date
      2013-11-28
    • Related Report
      2013 Annual Research Report 2013 Final Research Report
  • [Presentation] Role of natural helper cells a member of group 2 innate lymphoid cells2013

    • Author(s)
      Kazuyo Moro
    • Organizer
      The 12th FIMSA Advanced Training Course
    • Place of Presentation
      タイ
    • Year and Date
      2013-10-22
    • Related Report
      2013 Final Research Report
  • [Presentation] Th2型アレルギーにおけるナチュラルヘルパー細胞の役割2013

    • Author(s)
      茂呂和世
    • Organizer
      第7回順天堂眼アレルギー研究会
    • Place of Presentation
      東京
    • Year and Date
      2013-09-26
    • Related Report
      2013 Annual Research Report 2013 Final Research Report
  • [Presentation] 新規同定されたリンパ球ナチュラルヘルパー細胞が喘息を悪化させるメカニズム2013

    • Author(s)
      茂呂和世
    • Organizer
      第15回愛知免疫アレルギーを語る会
    • Place of Presentation
      愛知
    • Year and Date
      2013-09-11
    • Related Report
      2013 Final Research Report
  • [Presentation] TSLP induces corticosteroid resistance of natural helper cell and evokes severe asthma2013

    • Author(s)
      Kazuyo Moro
    • Organizer
      15th International Congress of Immunology
    • Place of Presentation
      ミラノ
    • Year and Date
      2013-08-27
    • Related Report
      2013 Final Research Report
  • [Presentation] 新しいリンパ球「ナチュラルヘルパー細胞」2013

    • Author(s)
      茂呂和世
    • Organizer
      第37回阿蘇シンポジウム
    • Place of Presentation
      熊本
    • Year and Date
      2013-08-03
    • Related Report
      2013 Annual Research Report 2013 Final Research Report
  • [Presentation] Role of NH cells in IL-33-mediate diseases in the lung2013

    • Author(s)
      Kazuyo Moro
    • Organizer
      The 23rd congress of Interasma Japan / North Asia
    • Place of Presentation
      東京
    • Year and Date
      2013-06-29
    • Related Report
      2013 Final Research Report
  • [Presentation] ナチュラルヘルパー細胞とアレルギー性疾患2013

    • Author(s)
      茂呂和世
    • Organizer
      第17回GI Cell Biology研究会
    • Place of Presentation
      東京
    • Year and Date
      2013-06-20
    • Related Report
      2013 Annual Research Report 2013 Final Research Report
  • [Presentation] TSLP induces corticosteroid resistance of natural helper cell and evokes severe asthma2013

    • Author(s)
      Kazuyo Moro
    • Organizer
      5th International Workshop of Kyoto T Cell Conference
    • Place of Presentation
      京都
    • Year and Date
      2013-06-06
    • Related Report
      2013 Annual Research Report 2013 Final Research Report
  • [Presentation] 重症喘息におけるナチュラルヘルパー細胞の役割2013

    • Author(s)
      茂呂和世、加畑宏樹、浅野浩一郎、小安重夫
    • Organizer
      第25回アレルギー学会春期臨床大会
    • Place of Presentation
      横浜
    • Year and Date
      2013-05-11
    • Related Report
      2013 Annual Research Report 2013 Final Research Report
  • [Presentation] 寄生虫感染におけるナチュラルヘルパー細胞の役割2013

    • Author(s)
      茂呂和世
    • Organizer
      第6回寄生虫感染免疫研究会
    • Place of Presentation
      大分
    • Year and Date
      2013-03-09
    • Related Report
      2013 Final Research Report
  • [Presentation] IL-33-dependent eosinophilia in the lung mediated by natural helper cells2013

    • Author(s)
      Kazuyo Moro
    • Organizer
      Frontiers in Immunology and Inflammation
    • Place of Presentation
      東京
    • Year and Date
      2013-02-13
    • Related Report
      2013 Final Research Report
  • [Presentation] Structural characteristics of Fat-associated lymphoid cluster in adipose tissue2012

    • Author(s)
      Kazuyo Moro, Shigeo Koyasu
    • Organizer
      第41回日本免疫学会総会・学術集会記録
    • Place of Presentation
      神戸
    • Year and Date
      2012-12-05
    • Related Report
      2013 Final Research Report
  • [Presentation] Critical roles of natural helper cells in IL-33 dependent lung eosinophilia upon helminth infection2012

    • Author(s)
      Kazuyo Moro
    • Organizer
      International Endotoxin and Innate Immunity Society Meeting 2012
    • Place of Presentation
      東京
    • Year and Date
      2012-10-24
    • Related Report
      2013 Final Research Report
  • [Presentation] 自然免疫機構におけるナチュラルヘルパー細胞の役割2012

    • Author(s)
      茂呂和世
    • Organizer
      第6回TOkushima Young Investigators Conference
    • Place of Presentation
      徳島
    • Year and Date
      2012-09-18
    • Related Report
      2013 Final Research Report
  • [Presentation] 新しいリンパ球ナチュラルヘルパー細胞2012

    • Author(s)
      茂呂和世
    • Organizer
      第52回生化学若い研究者の会
    • Place of Presentation
      愛知
    • Year and Date
      2012-08-24
    • Related Report
      2013 Final Research Report
  • [Presentation] アレルギーにおけるナチュラルヘルパー細胞の役割2012

    • Author(s)
      茂呂和世
    • Organizer
      ロチェスター・カンファレンス
    • Place of Presentation
      東京
    • Year and Date
      2012-06-27
    • Related Report
      2013 Final Research Report 2012 Research-status Report
  • [Presentation] ナチュラルヘルパー細胞の寄生虫感染・アレルギーにおける役割2012

    • Author(s)
      茂呂和世、小安重夫
    • Organizer
      第77回日本インターフェロンサイトカイン学会学術集会
    • Place of Presentation
      神戸
    • Year and Date
      2012-06-22
    • Related Report
      2013 Final Research Report
  • [Presentation] IL-33-dependent eosinophilia in the lung mediated by natural helper cells2012

    • Author(s)
      Kazuyo Moro
    • Organizer
      20th International Symposium on Molecular Cell Biology of Macrophages
    • Place of Presentation
      東京
    • Year and Date
      2012-06-15
    • Related Report
      2013 Final Research Report
  • [Presentation] 自然免疫で活躍する新しいリンパ球~ナチュラルヘルパー細胞~

    • Author(s)
      茂呂和世、小安重夫
    • Organizer
      第117回日本眼科学会総会
    • Place of Presentation
      東京
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] Role of NH cells in IL-33-mediate diseases in the lung

    • Author(s)
      Kazuyo Moro
    • Organizer
      The 23rd congress of Interasma Japan / North Atia
    • Place of Presentation
      東京
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] TSLP induces corticosteroid resistance of natural helper cell and evokes severe asthma

    • Author(s)
      Kazuyo Moro
    • Organizer
      15th International Congress of Immunology
    • Place of Presentation
      Milan, Italy
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] 新規同定されたリンパ球ナチュラルヘルパー細胞が喘息を悪化させるメカニズム

    • Author(s)
      茂呂和世
    • Organizer
      第15回愛知免疫アレルギーを語る会
    • Place of Presentation
      名古屋
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] Role of natural helper cells. A member of group 2 innate lymphoid cells

    • Author(s)
      Kazuyo Moro
    • Organizer
      The 12th FIMSA Advanced Training Course
    • Place of Presentation
      Chiang Mai, Thailand
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] Natural Helper Cell ~a new player in innate immune system~

    • Author(s)
      Kazuyo Moro
    • Organizer
      Annual Meeting of The Japanese Society for Immunology, 2013
    • Place of Presentation
      千葉
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] IL-33-dependent eosinophilia in the lung mediated by natural helper cells.

    • Author(s)
      Kazuyo Moro
    • Organizer
      20th International Symposium on Molecular Cell Biology of Macrophages 2012
    • Place of Presentation
      Tokyo
    • Related Report
      2012 Research-status Report
    • Invited
  • [Presentation] ナチュラルヘルパー細胞の寄生虫感染・アレルギーにおける役割

    • Author(s)
      茂呂和世
    • Organizer
      第77回日本インターフェロンサイトカイン学会学術集会
    • Place of Presentation
      神戸
    • Related Report
      2012 Research-status Report
    • Invited
  • [Presentation] Natural helper cells in IL-33 dependent lung eosinophilia upon helminth infection

    • Author(s)
      Kazuyo Moro
    • Organizer
      International Endotoxin and Innate Immunity Society Meeting 2012
    • Place of Presentation
      Tokyo
    • Related Report
      2012 Research-status Report
    • Invited
  • [Presentation] Structural characteristics of Fat-associated lymphoid cluster in adipose tissue

    • Author(s)
      茂呂和世
    • Organizer
      第41回日本免疫学会総会・学術集会記録
    • Place of Presentation
      神戸
    • Related Report
      2012 Research-status Report
  • [Book] 実験医学2012

    • Author(s)
      茂呂和世
    • Publisher
      羊土社
    • Related Report
      2012 Research-status Report
  • [Remarks]

    • URL

      http://web.rcai.riken.jp/en/labo/immunecellsystem/

    • Related Report
      2013 Final Research Report
  • [Remarks] 理化学研究所統合生命医科学センター免疫細胞システム研究グループ

    • URL

      http://www.riken.jp/research/labs/ims/immun_cell_sys/

    • Related Report
      2013 Annual Research Report
  • [Remarks] RIKEN MIS-RCAI 免疫細胞システム研究グループ

    • URL

      http://web.rcai.riken.jp/en/labo/immunecellsystem/

    • Related Report
      2012 Research-status Report

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Published: 2013-05-31   Modified: 2019-07-29  

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