| Project/Area Number |
24659379
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Circulatory organs internal medicine
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| Research Institution | Hokkaido University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
KINUGAWA Shintaro 北海道大学, 大学院・医学研究科, 講師 (60399871)
ISHIMORI Naoki 北海道大学, 大学院・医学研究科, 助教 (70399848)
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| Project Period (FY) |
2012
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| Project Status |
Completed (Fiscal Year 2012)
|
| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2012: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
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| Keywords | 動脈硬化 / 炎症性サイトカイン / ナチュラルキラーT 細胞 / Th1/Th2 バランス / 樹状細胞 / ナチュラルキラーT細胞 / Th1/Th2バランス |
|---|
| Research Abstract |
The development and progression of atherosclerosis involves complex inflammatory processes between hematocytes and vascular tissues. Natural killer T (NKT) cells, a unique subset of T lymphocytes that recognize glycolipid antigens and secrete a large amount of TH1/TH2 cytokines, play a crucial role in regulating tissue inflammation. The present study demonstrated that inflammatory process regulated via NKT cells is involved in atherosclerotic lesions and NKT cells may be the novel therapeutic targets in atherosclerotic vascular diseases.
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