Elucidation of the involvement of the inflammatory response and development of a new marker and treatment in lung cancer growth

• Project/Area Number: 24659407
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Respiratory organ internal medicine
• Research Institution: Kagoshima University
• Principal Investigator: MIZUNO Keiko 鹿児島大学, 医学部・歯学部附属病院, 助教 (50531414)
• Co-Investigator(Kenkyū-buntansha): INOUE Hiromasa 鹿児島大学, 大学院医歯学総合研究科呼吸器内科学, 教授 (30264039)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000); Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2012: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
• Keywords: 肺癌 / マイクロアレイ / マイクロRNA / 遺伝子 / miR-1/133a / microRNA / IL-13 / 炎症性サイトカイン

Outline of Final Research Achievements

The results of the microarray analysis in lung squamous cell carcinoma clinical specimens was extracted several microRNA group showed a significant decrease in expression as compared to normal lung tissue. Among them which is one miR-1 / 133a cluster of has been reported decreased expression in bladder cancer, head and neck cancer and the like, in the present study revealed that there is a tumor suppressor effect in lung squamous cell carcinoma. Also inhibition of the target gene I got results suggest that are deeply involved in the migration and invasion suppressor function of cancer cells. Furthermore miR-206 is I revealed to have an inhibitory action of key genes in lung cancer. The elucidation of the tumor suppression mechanism it was considered that there is a possibility that lead to the development of future new therapies.

Research Products

• [Journal Article] Tumor-suppressive microRNA-206 as a dual inhibitor of MET and EGFR oncogenic signaling in lung squamous cell carcinoma (2015)
  • Author(s): Mataki H, Seki N, Chiyomaru T, Enokida H, Goto Y, Kumamoto T, Machida K, Mizuno K, Nakagawa M, Inoue H.
  • Journal Title: International Journal of Oncology Volume: 46 Issue: 3 Pages: 1039-1050
  • DOI: 10.3892/ijo.2014.2802
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Downregulation of the microRNA-1/133a cluster enhances cancer cell migration and invasion in lung-squamous cell carcinoma via regulation of Coronin1C (2015)
  • Author(s): Mataki H, Enokida H, Chiyomaru T, Mizuno K, Matsushita R, Goto Y, Nishikawa R, Higashimoto I, Samukawa T, Nakagawa M, Inoue H, Seki N.
  • Journal Title: Journal of Human Genetics Volume: 60 Issue: 2 Pages: 53-61
  • DOI: 10.1038/jhg.2014.111
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Presentation] 肺扁平上皮癌における腫瘍抑制性micro RNA-1/133aクラスタに関する検討 (2015)
  • Author(s): 3)俣木浩子、水野圭子、井上博雅、他
  • Organizer: 第55回日本呼吸器学会学術講演会
  • Place of Presentation: 東京
  • Year and Date: 2015-04-17 – 2015-04-19
• [Presentation] MicroRNA-206 function as a tumor suppressor via targeting MET in lung squamous cell carcinoma. (2014)
  • Author(s): 俣木浩子、水野圭子、井上博雅、他
  • Organizer: 第73回日本癌学会学術総会
  • Place of Presentation: 横浜
  • Year and Date: 2014-09-25 – 2014-09-27
• [Presentation] microRNA-206 function as a tumor suppressor via targeting MET in lung squamous cell carcinoma (2014)
  • Author(s): Hiroko Mataki, Naohiko Seki, Takeshi Chiyomaru, Hideki Enokida, Keiko Mizuno, Masayuki Nakagawa, Hiromasa Inoue
  • Organizer: 日本癌学会
  • Place of Presentation: パシフィコ横浜