| Project/Area Number |
24659407
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Respiratory organ internal medicine
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| Research Institution | Kagoshima University |
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Principal Investigator |
MIZUNO Keiko 鹿児島大学, 医学部・歯学部附属病院, 助教 (50531414)
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| Co-Investigator(Kenkyū-buntansha) |
INOUE Hiromasa 鹿児島大学, 大学院医歯学総合研究科呼吸器内科学, 教授 (30264039)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2012: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 肺癌 / マイクロアレイ / マイクロRNA / 遺伝子 / miR-1/133a / microRNA / IL-13 / 炎症性サイトカイン |
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| Outline of Final Research Achievements |
The results of the microarray analysis in lung squamous cell carcinoma clinical specimens was extracted several microRNA group showed a significant decrease in expression as compared to normal lung tissue. Among them which is one miR-1 / 133a cluster of has been reported decreased expression in bladder cancer, head and neck cancer and the like, in the present study revealed that there is a tumor suppressor effect in lung squamous cell carcinoma. Also inhibition of the target gene I got results suggest that are deeply involved in the migration and invasion suppressor function of cancer cells. Furthermore miR-206 is I revealed to have an inhibitory action of key genes in lung cancer. The elucidation of the tumor suppression mechanism it was considered that there is a possibility that lead to the development of future new therapies.
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