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Elucidation of the involvement of the inflammatory response and development of a new marker and treatment in lung cancer growth

Research Project

Project/Area Number 24659407
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Respiratory organ internal medicine
Research InstitutionKagoshima University

Principal Investigator

MIZUNO Keiko  鹿児島大学, 医学部・歯学部附属病院, 助教 (50531414)

Co-Investigator(Kenkyū-buntansha) INOUE Hiromasa  鹿児島大学, 大学院医歯学総合研究科呼吸器内科学, 教授 (30264039)
Project Period (FY) 2012-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2012: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywords肺癌 / マイクロアレイ / マイクロRNA / 遺伝子 / miR-1/133a / microRNA / IL-13 / 炎症性サイトカイン
Outline of Final Research Achievements

The results of the microarray analysis in lung squamous cell carcinoma clinical specimens was extracted several microRNA group showed a significant decrease in expression as compared to normal lung tissue. Among them which is one miR-1 / 133a cluster of has been reported decreased expression in bladder cancer, head and neck cancer and the like, in the present study revealed that there is a tumor suppressor effect in lung squamous cell carcinoma. Also inhibition of the target gene I got results suggest that are deeply involved in the migration and invasion suppressor function of cancer cells. Furthermore miR-206 is I revealed to have an inhibitory action of key genes in lung cancer. The elucidation of the tumor suppression mechanism it was considered that there is a possibility that lead to the development of future new therapies.

Report

(4 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • 2012 Research-status Report
  • Research Products

    (5 results)

All 2015 2014

All Journal Article (2 results) (of which Peer Reviewed: 2 results,  Open Access: 2 results,  Acknowledgement Compliant: 2 results) Presentation (3 results)

  • [Journal Article] Tumor-suppressive microRNA-206 as a dual inhibitor of MET and EGFR oncogenic signaling in lung squamous cell carcinoma2015

    • Author(s)
      Mataki H, Seki N, Chiyomaru T, Enokida H, Goto Y, Kumamoto T, Machida K, Mizuno K, Nakagawa M, Inoue H.
    • Journal Title

      International Journal of Oncology

      Volume: 46 Issue: 3 Pages: 1039

    • DOI

      10.3892/ijo.2014.2802

    • URL

      https://localhost/en/publications/fe60bff1-81a5-4b4c-8b1a-78995f8c63b0

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Downregulation of the microRNA-1/133a cluster enhances cancer cell migration and invasion in lung-squamous cell carcinoma via regulation of Coronin1C2015

    • Author(s)
      Mataki H, Enokida H, Chiyomaru T, Mizuno K, Matsushita R, Goto Y, Nishikawa R, Higashimoto I, Samukawa T, Nakagawa M, Inoue H, Seki N.
    • Journal Title

      Journal of Human Genetics

      Volume: 60 Issue: 2 Pages: 53

    • DOI

      10.1038/jhg.2014.111

    • NAID

      40020367992

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Presentation] 肺扁平上皮癌における腫瘍抑制性micro RNA-1/133aクラスタに関する検討2015

    • Author(s)
      3)俣木浩子、水野圭子、井上博雅、他
    • Organizer
      第55回日本呼吸器学会学術講演会
    • Place of Presentation
      東京
    • Year and Date
      2015-04-17 – 2015-04-19
    • Related Report
      2014 Annual Research Report
  • [Presentation] MicroRNA-206 function as a tumor suppressor via targeting MET in lung squamous cell carcinoma.2014

    • Author(s)
      俣木浩子、水野圭子、井上博雅、他
    • Organizer
      第73回日本癌学会学術総会
    • Place of Presentation
      横浜
    • Year and Date
      2014-09-25 – 2014-09-27
    • Related Report
      2014 Annual Research Report
  • [Presentation] microRNA-206 function as a tumor suppressor via targeting MET in lung squamous cell carcinoma2014

    • Author(s)
      Hiroko Mataki, Naohiko Seki, Takeshi Chiyomaru, Hideki Enokida, Keiko Mizuno, Masayuki Nakagawa, Hiromasa Inoue
    • Organizer
      日本癌学会
    • Place of Presentation
      パシフィコ横浜
    • Related Report
      2013 Research-status Report

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Published: 2013-05-31   Modified: 2019-07-29  

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