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Role of INTS6 in the adipose differentiation

Research Project

Project/Area Number 24659445
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeSingle-year Grants
Research Field Metabolomics
Research InstitutionHiroshima University

Principal Investigator

ASANO Tomoichiro  広島大学, 医歯薬保健学研究院, 教授 (70242063)

Project Period (FY) 2012-04-01 – 2014-03-31
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
KeywordsINTS6 / 脂肪細胞 / 代謝 / 分化 / 肥満 / INTS6 / 糖尿病 / 代謝調節 / インスリン抵抗性
Research Abstract

We demonstrated that expression levels ofIntS6 and IntS11, subunits ofthe Integrator complex, were increased in 3T3-L1 cells in the period when the cells reach edconfluenceand differentiated into adipocytes, while being reduced tobasal levels after the completion ofdifferentiation. Suppre ssion of IntS6 or IntS11 expression using siRNAs in3T3-L1 pre-adipocytes markedly inhibited differentiation into mature adipocytes. These findings demonstrate that increased expression of Integrator complex subunits is an indispensable event in adipose differentiation. Although further study is necessary to elucidate the underlying mechanism, the processing of U1, U2 small nuclear RNAs may be involved in cell differentiation steps.

Report

(3 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • Research Products

    (75 results)

All 2014 2013 2012

All Journal Article (36 results) (of which Peer Reviewed: 32 results) Presentation (37 results) (of which Invited: 4 results) Patent(Industrial Property Rights) (2 results)

  • [Journal Article] The inflammation-lipocalin 2 axis may contribute to the development of chronic kidney disease.2014

    • Author(s)
      Hashikata A, Yamashita A, Suzuki S, Nagayasu S, Shinjo T, Taniguchi A, Fukushima M, Nakai Y, Nin K, Watanabe N, Asano T, Abiko Y, Kushiyama A, Nagasaka S, Nishimura F.
    • Journal Title

      Nephrol Dial Transplant.

      Volume: 29 Pages: 611-8

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Lactobacillus casei strain Shirota protects against nonalcoholic steatohepatitis development in a rodent model.2014

    • Author(s)
      Okubo H, Sakoda H, Kushiyama A, Fujishiro M, Nakatsu Y, Fukushima T, Matsunaga Y, Kamata H, Asahara T, Yoshida Y, Chonan O, Iwashita M, Nishimura F, Asano T.
    • Journal Title

      Am J Physiol Gastrointest Liver Physiol.

      Volume: 305

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Insulin receptor substrate-1 (IRS-1) forms a ribonucleoprotein complex associated with polysomes.2014

    • Author(s)
      Ozoe A, Sone M, Fukushima T, Kataoka N, Arai T, Chida K, Asano T, Hakuno F, Takahashi S.
    • Journal Title

      FEBS Lett.

      Volume: 587 Pages: 2319-24

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Lactobacillus casei strain Shirota protects against non-alcoholic steatohepatitis development in a rodent model2013

    • Author(s)
      Okubo, H., Sakoda, H., ,Nakatsu, Y., Asano, T.
    • Journal Title

      Am. J. Physiol. Gastrointest Liver Physiol

      Volume: 305

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Par14 protein associates with insulin receptor substrate 1 (IRS-1), thereby enhancing insulin-induced IRS-1 phosphorylation and metabolic actions2013

    • Author(s)
      Zhang, J.,Nakatsu, Y., Fukushima, T., Asano, T.
    • Journal Title

      J. Biol. Chem

      Volume: 288 Pages: 20692-701

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Resistin-Like MoleculeβIs Abundantly Expressed in Foam Cells and Is Involved in Atherosclerosis Development2013

    • Author(s)
      Kushiyama, A.,,Nakatsu, Y., Asano, T.
    • Journal Title

      Arterioscler. Thromb. Vasc. Biol

      Volume: 33 Pages: 1986-93

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Insulin Receptor Substrate-1 (IRS-1) Forms a Ribonucleoprotein Complex Associated with Polysomes2013

    • Author(s)
      Ozoe, A., Sone, M., Fukushima, T., Asano, T.
    • Journal Title

      FEBS Letters

      Volume: 587 Pages: 2319-24

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Valsartan restores inflammatory response by macrophages in adipose and hepatic tissues of LPS-infused mice2013

    • Author(s)
      Iwashita, M., Nakatsu, Y., Fukushima, T., Asano, T.
    • Journal Title

      Adipocyte

      Volume: 2 Pages: 28-32

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Integrator complex plays an essential role in adipose differentiation2013

    • Author(s)
      O tani, Y., Nakatsu, Y., Asano, T.
    • Journal Title

      Biochem. Biophys. Res. Commun

      Volume: 434 Pages: 197-202

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Importance of endothelial NF-κB signalling in vascular remodelling and aortic aneurysm formation2013

    • Author(s)
      S aito, T., Hasegawa, Y., Asano, T.
    • Journal Title

      Cardiovascular Res

      Volume: 97 Pages: 106-14

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] mTORC1/2による代謝調節2013

    • Author(s)
      浅野知一郎,中津祐介
    • Journal Title

      内分泌・糖尿病・代謝内科

      Volume: 37(6) Pages: 667-675

    • NAID

      40019914834

    • Related Report
      2013 Final Research Report
  • [Journal Article] SGLT2阻害薬の作用機序と治療への展望(特集糖尿病治療薬の最前線 : 臨床試験・臨床疫学的観点も含めて)2013

    • Author(s)
      浅野知一郎,大久保博史,中津祐介
    • Journal Title

      医薬ジャーナル

      Volume: 49(10) Pages: 94-99

    • NAID

      40019822321

    • Related Report
      2013 Final Research Report
  • [Journal Article] Par14 protein associates with insulin receptor substrate 1 (IRS-1), thereby enhancing insulin-induced IRS-1 phosphorylation and metabolic actions.2013

    • Author(s)
      Zhang J, Nakatsu Y, Shinjo T, Guo Y, Sakoda H, Yamamotoya T, Otani Y, Okubo H, Kushiyama A, Fujishiro M, Fukushima T, Tsuchiya Y, Kamata H, Iwashita M, Nishimura F, Katagiri H, Takahashi S, Kurihara H, Uchida T, Asano T.
    • Journal Title

      J Biol Chem.

      Volume: 288 Pages: 20692-701

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Resistin-like molecule β is abundantly expressed in foam cells and is involved in atherosclerosis development.2013

    • Author(s)
      Kushiyama A, Sakoda H, Oue N, Okubo M, Nakatsu Y, Ono H, Fukushima T, Kamata H, Nishimura F, Kikuchi T, Fujishiro M, Nishiyama K, Aburatani H, Kushiyama S, Iizuka M, Taki N, Encinas J, Sentani K, Ogonuki N, Ogura A, Kawazu S, Yasui W, Higashi Y, Kurihara H, Katagiri H, Asano T.
    • Journal Title

      Arterioscler Thromb Vasc Biol.

      Volume: 33 Pages: 1986-93

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Valsartan restores inflammatory response by macrophages in adipose and hepatic tissues of LPS-infused mice.2013

    • Author(s)
      Iwashita M, Nakatsu Y, Sakoda H, Fujishiro M, Kushiyama A, Fukushima T, Kumamoto S, Shinjo T, Kamata H, Nishimura F, Asano T.
    • Journal Title

      Adipocyte

      Volume: 2 Pages: 28-32

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Integrator complex plays an essential role in adipose differentiation.2013

    • Author(s)
      Otani Y, Nakatsu Y, Sakoda H, Fukushima T, Fujishiro M, Kushiyama A, Okubo H, Tsuchiya Y, Ohno H, Takahashi S, Nishimura F, Kamata H, Katagiri H, Asano T.
    • Journal Title

      Biochem Biophys Res Commun.

      Volume: 434 Pages: 197-202

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Role of Pin1 protein in the pathogenesis of nonalcoholic steatohepatitis in a rodent model2012

    • Author(s)
      Nakatsu, Y.,Otani, Y., Fukushima, T., Asano, T.
    • Journal Title

      J. Biol. Chem

      Volume: 287 Pages: 44526-35

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Angiotensin receptor 1 blocker valsartan normalizes gene expression profiles of 3T3-L1 adipocytes altered by co-culture with LPS-treated RAW264.7 macrophages2012

    • Author(s)
      Kumamoto, S., Nakatsu, Y., Fukushima, T., Asano, T.
    • Journal Title

      Obesity Res Clin Pract

      Volume: 6

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Phosphatidylinositol 3-kinase (PI3K) activity bound to insulin-like growth factor-I (IGF-I) receptor, which is continuously sustained by IGF-I stimulation, is required for IGF-I-induced cell proliferation2012

    • Author(s)
      Fukushima, T., Nakamura, T., Nakatsu, Y., Asano, T.
    • Journal Title

      J. Biol. Chem

      Volume: 287 Pages: 29713-21

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Insulin/insulin-like growth factor (IGF) stimulation abrogates an association between a deubiquitinating enzyme USP7 and insulin receptor substrates (IRSs) followed by proteasomal degradation of IRSs2012

    • Author(s)
      Yoshihara, H., Fukushima, T., Asano, T.
    • Journal Title

      Biochem. Biophys. Res. Commun

      Volume: 423 Pages: 122-7

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Prolyl isomerase Pin1 regulates mouse embryonic fibroblast differentiation into adipose cells2012

    • Author(s)
      Uchida, T., Furumai, K., Asano, T.
    • Journal Title

      PLoS One

      Volume: 7(3)

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Blockade of the nuclear factor-κB pathway in the endothelium prevents insulin resistance and prolongs life spans2012

    • Author(s)
      Hasegawa, Y., Saito, T., Asano, T.
    • Journal Title

      Circulation

      Volume: 125(9) Pages: 1122-33

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Valsartan, independently of AT1 receptor or PPAR, suppresses LPS-induced macrophage activation and improves insulin resistance in co-cultured adipocytes2012

    • Author(s)
      Iwashita, M., Sakoda, H., ,Nakatsu, Y., Asano, T.
    • Journal Title

      Am. J. Physiol. Endo. Metab

      Volume: 302

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Xanthine oxidoreductase is involved in macrophage foam cell formation and atherosclerosis development2012

    • Author(s)
      Kushiyama, A., Okubo, H., Asano, T.
    • Journal Title

      Arterioscler Thromb Vasc Biol

      Volume: 32 Pages: 291-8

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Pin1 associates with and induces translocation of CRTC2 to the cytosol, thereby suppressing CRE transcriptional activity2012

    • Author(s)
      Kikuchi, T., Zhang, J.,Nakatsu, Y., Asano, T.
    • Journal Title

      Obesity Res Clin Pract

      Volume: 6

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Adipocyte-macrophage interaction may mediate LPS-induced low-grade inflammation : potential link with metabolic complications2012

    • Author(s)
      Nakarai, H., Yamashita, A., Asano, T.
    • Journal Title

      Innate Immun

      Volume: 18 Pages: 164-70

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] AMPKを介するエネルギー代謝調節2012

    • Author(s)
      中津祐介,浅野知一郎
    • Journal Title

      日本薬理學雜誌

      Volume: 140(3) Pages: 138-139

    • NAID

      10031072155

    • Related Report
      2013 Final Research Report
  • [Journal Article] 糖尿病治療の分子標的としてのグルコーストランスポーター(特集新たな創薬ターゲットとしてのトランスポーター : 明らかになるその構造と新機能)2012

    • Author(s)
      大久保博史,中津祐介,浅野知一郎
    • Journal Title

      細胞工学

      Volume: 31(5) Pages: 548-552

    • NAID

      40019307436

    • Related Report
      2013 Final Research Report
  • [Journal Article] Phosphatidylinositol 3-kinase (PI3K) activity bound to insulin-like growth factor-I (IGF-I) receptor, which is continuously sustained by IGF-I stimulation, is required for IGF-I-induced cell proliferation.2012

    • Author(s)
      Fukushima, T.
    • Journal Title

      J. Biol. Chem.

      Volume: 287 Pages: 29713-29721

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] A deubiquitinating enzyme, USP7, is associated with insulin receptor substrates (IRSs) forming a negative feedback loop in insulin/insulin-like growth factor (IGF) signaling2012

    • Author(s)
      Yoshihara, H.
    • Journal Title

      Biochem. Biophys. Res. Commun.

      Volume: 423 Pages: 122-127

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Prolyl isomerase Pin1 regulates mouse embryonic fibroblast differentiation into adipose cells.2012

    • Author(s)
      Uchida., T.
    • Journal Title

      PLoS One

      Volume: 7

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Blockade of the nuclear factor-κB pathway in the endothelium prevents insulin resistance and prolongs life spans.2012

    • Author(s)
      Hasegawa, Y.
    • Journal Title

      Circulation

      Volume: 125 Pages: 1122-1133

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Valsartan, independently of AT1 receptor or PPAR, suppresses LPS-induced macrophage activation and improves insulin resistance in co-cultured adipocytes2012

    • Author(s)
      Iwasita, M.
    • Journal Title

      Am. J. Physiol. Cell Physiol.

      Volume: 302

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Xanthine oxidoreductase is involved in macrophage foam cell formation and atherosclerosis development2012

    • Author(s)
      Kushiyama, A.
    • Journal Title

      Arterioscler Thromb Vasc Biol.

      Volume: 32 Pages: 291-298

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] LST8 level controls basal p70 S6 kinase and Akt phosphorylations, and mTORC1 and mTORC2 negatively regulate each other by competing for association with LST82012

    • Author(s)
      Kikuchi, T.
    • Journal Title

      Obesity Res Clin Pract.

      Volume: 6

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Adipocyte-macrophage interaction may mediate LPS-induced low-grade inflammation: potential link with metabolic complications.2012

    • Author(s)
      Nakarai, H.
    • Journal Title

      Innate Immun

      Volume: 18 Pages: 164-70

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Presentation] プロリン異性化酵素Pin1を介したAMPK機能制御機構の解明2013

    • Author(s)
      中津祐介、岩下未咲、松永泰花、福嶋俊明、迫田秀之、櫛山暁史、鎌田英明、内田隆史、浅野知一郎
    • Organizer
      第25回分子糖尿病学シンポジウム
    • Place of Presentation
      大阪
    • Year and Date
      2013-12-07
    • Related Report
      2013 Final Research Report
  • [Presentation] メタボリックシンドローム発症におけるプロリン異性化酵素Pin1の役割2013

    • Author(s)
      浅野知一郎
    • Organizer
      第10回九州先進糖尿病研究会
    • Place of Presentation
      福岡
    • Year and Date
      2013-09-07
    • Related Report
      2013 Final Research Report
    • Invited
  • [Presentation] キサンチンオキシダーゼ阻害薬による動脈硬化予防の可能性2013

    • Author(s)
      浅野知一郎
    • Organizer
      第45回日本動脈硬化学会・学術集会
    • Place of Presentation
      東京
    • Year and Date
      2013-07-19
    • Related Report
      2013 Final Research Report
    • Invited
  • [Presentation] プロリン異性化酵素Pin1はAMPKとPPARαを制御して脂質代謝に関与する2013

    • Author(s)
      中津祐介、大久保博史、大谷裕一郎、松永泰花、山本屋武、藤城緑、鎌田英明、内田隆史、浅野知一郎
    • Organizer
      第56回日本糖尿病学会
    • Place of Presentation
      熊本
    • Year and Date
      2013-05-16
    • Related Report
      2013 Final Research Report
  • [Presentation] ストレプトゾトシン処理後の膵ランゲルハンス島に対するDPP4阻害薬SK-0403の改善作用2013

    • Author(s)
      岩下未咲、大久保博史、迫田秀之、藤城緑、櫛山暁史、中津祐介、福嶋俊明、新城尊徳、西村英紀、浅野知一郎
    • Organizer
      第56回日本糖尿病学会
    • Place of Presentation
      熊本
    • Year and Date
      2013-05-16
    • Related Report
      2013 Final Research Report
  • [Presentation] Integratorcomplexは脂肪細胞分化に必須の役割を果たしている2013

    • Author(s)
      松永泰花、大谷裕一郎、福嶋俊明、中津祐介、迫田秀之、山本屋武、鎌田英明、浅野知一郎
    • Organizer
      第56回日本糖尿病学会
    • Place of Presentation
      熊本
    • Year and Date
      2013-05-16
    • Related Report
      2013 Final Research Report
  • [Presentation] 低濃度LPS刺激条件下のメサンギウム細胞・マクロファージ共培養系におけるメサンギウム細胞の網羅的遺伝子解析2013

    • Author(s)
      山下明子、箸方厚之、岩下未咲、鈴木茂樹、安孫子宣光、櫛山暁史、浅野知一郎、西村英紀
    • Organizer
      第56回日本糖尿病学会
    • Place of Presentation
      熊本
    • Year and Date
      2013-05-16
    • Related Report
      2013 Final Research Report
  • [Presentation] DPP4阻害薬SK-0403はマクロファージ共培養系における脂肪細胞の炎症遺伝子の発現を抑制する2013

    • Author(s)
      新城尊徳、岩下未咲、中津祐介、迫田秀之、藤城緑、櫛山暁史、菊池貴子、西村英紀、浅野知一郎
    • Organizer
      第56回日本糖尿病学会
    • Place of Presentation
      熊本
    • Year and Date
      2013-05-16
    • Related Report
      2013 Final Research Report
  • [Presentation] LactobacilluscaseistrainShirota(LcS)投与による非アルコール性脂肪肝炎(NASH)の改善作用2013

    • Author(s)
      大久保博史、福嶋俊明、新城尊徳、西村英紀、藤城緑、櫛山暁史、菊池貴子、浅野知一郎
    • Organizer
      第56回日本糖尿病学会
    • Place of Presentation
      熊本
    • Year and Date
      2013-05-16
    • Related Report
      2013 Final Research Report
  • [Presentation] 脂肪酸合成酵素におけるPin1の作用2013

    • Author(s)
      山本屋武、中津祐介、松永泰花、新城尊徳、西村英紀、迫田秀之、櫛山暁史、鎌田英明、内田隆史、浅野知一郎
    • Organizer
      第56回日本糖尿病学会
    • Place of Presentation
      熊本
    • Year and Date
      2013-05-16
    • Related Report
      2013 Final Research Report
  • [Presentation] 高脂肪食負荷マウスにおけるmTORC2の糖脂質代謝に果たす役割の検討2013

    • Author(s)
      菊池貴子、迫田秀之、櫛山暁史、藤城緑、山本屋武、金子直、山崎広樹、浅野知一郎、河津捷二
    • Organizer
      第56回日本糖尿病学会
    • Place of Presentation
      熊本
    • Year and Date
      2013-05-16
    • Related Report
      2013 Final Research Report
  • [Presentation] 非アルコール性脂肪性肝炎(NASH)に対するクエン酸モサプリド投与の効果2013

    • Author(s)
      藤城緑、中津祐介、大谷裕一郎、大久保博史、岩下未咲、西村英紀、迫田秀之、櫛山暁史、菊池貴子、浅野知一郎
    • Organizer
      第56回日本糖尿病学会
    • Place of Presentation
      熊本
    • Year and Date
      2013-05-16
    • Related Report
      2013 Final Research Report
  • [Presentation] メタボリックシンドローム発症におけるプロリン異性化酵素Pin1の役割2013

    • Author(s)
      浅野 知一郎
    • Organizer
      第10回九州先進糖尿病研究会
    • Place of Presentation
      福岡
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] キサンチンオキシダーゼ阻害剤による動脈硬化予防の可能性2013

    • Author(s)
      浅野 知一郎
    • Organizer
      第45回日本動脈硬化学会総会・学術集会
    • Place of Presentation
      東京
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] プロリン異性化酵素Pin1はAMPKとPPARαを制御して脂質代謝に関与する2013

    • Author(s)
      中津祐介、大久保博史、大谷裕一郎、松永泰花、山本屋武、藤城緑、鎌田英明、内田隆史、浅野知一郎
    • Organizer
      第56回日本糖尿病学会
    • Place of Presentation
      熊本
    • Related Report
      2013 Annual Research Report
  • [Presentation] ストレプトゾトシン処理後の膵ランゲルハンス島に対するDPP4阻害薬SK-0403の改善作用2013

    • Author(s)
      岩下未咲、大久保博史、迫田秀之、藤城緑、櫛山暁史、中津祐介、福嶋俊明、新城尊徳、西村英紀、浅野知一郎
    • Organizer
      第56回日本糖尿病学会
    • Place of Presentation
      熊本
    • Related Report
      2013 Annual Research Report
  • [Presentation] Integrator complexは脂肪細胞分化に必須の役割を果たしている2013

    • Author(s)
      松永泰花、大谷裕一郎、福嶋俊明、中津祐介、迫田秀之、山本屋武、鎌田英明、浅野知一郎
    • Organizer
      第56回日本糖尿病学会
    • Place of Presentation
      熊本
    • Related Report
      2013 Annual Research Report
  • [Presentation] 低濃度LPS刺激条件下のメサンギウム細胞・マクロファージ共培養系におけるメサンギウム細胞の網羅的遺伝子解析2013

    • Author(s)
      山下明子、箸方厚之、岩下未咲、鈴木茂樹、安孫子宣光、櫛山暁史、浅野知一郎、西村英紀
    • Organizer
      第56回日本糖尿病学会
    • Place of Presentation
      熊本
    • Related Report
      2013 Annual Research Report
  • [Presentation] DPP4阻害薬SK-0403はマクロファージ共培養系における脂肪細胞の炎症遺伝子の発現を抑制する。2013

    • Author(s)
      新城尊徳、岩下未咲、中津祐介、迫田秀之、藤城緑、櫛山暁史、菊池貴子、西村英紀、浅野知一郎
    • Organizer
      第56回日本糖尿病学会
    • Place of Presentation
      熊本
    • Related Report
      2013 Annual Research Report
  • [Presentation] Lactobacillus casei strain Shirota (LcS)投与による非アルコール性脂肪肝炎(NASH)の改善作用2013

    • Author(s)
      大久保博史、福嶋俊明、新城尊徳、西村英紀、藤城緑、櫛山暁史、菊池貴子、浅野知一郎
    • Organizer
      第56回日本糖尿病学会
    • Place of Presentation
      熊本
    • Related Report
      2013 Annual Research Report
  • [Presentation] 脂肪酸合成酵素におけるPin1の作用2013

    • Author(s)
      山本屋武、中津祐介、松永泰花、新城尊徳、西村英紀、迫田秀之、櫛山暁史、鎌田英明、内田隆史、浅野知一郎
    • Organizer
      第56回日本糖尿病学会
    • Place of Presentation
      熊本
    • Related Report
      2013 Annual Research Report
  • [Presentation] 高脂肪食負荷マウスにおけるmTORC2の糖脂質代謝に果たす役割の検討2013

    • Author(s)
      菊池貴子、迫田秀之、櫛山暁史、藤城緑、山本屋武、金子直、山崎広貴、浅野知一郎、河津捷二
    • Organizer
      第56回日本糖尿病学会
    • Place of Presentation
      熊本
    • Related Report
      2013 Annual Research Report
  • [Presentation] 非アルコール性脂肪性肝炎(NASH)に対するクエン酸モサプリド投与の効果2013

    • Author(s)
      藤城緑、中津祐介、大谷裕一郎、大久保博史、岩下未咲、西村英紀、迫田秀之、櫛山暁史、菊池貴子、浅野知一郎
    • Organizer
      第56回日本糖尿病学会
    • Place of Presentation
      熊本
    • Related Report
      2013 Annual Research Report
  • [Presentation] インスリン抵抗性および大血管障害におけるマクロファージ由来resistin like moleculeβの意義2012

    • Author(s)
      櫛山暁史、大久保博史、迫田秀之、菊池貴子、中津祐介、山本屋武、山崎広貴、藤城緑、門脇孝、鎌田英明、河津捷二、浅野知一郎
    • Organizer
      第24回分子糖尿病学シンポジウム
    • Place of Presentation
      東京
    • Year and Date
      2012-12-08
    • Related Report
      2013 Final Research Report
  • [Presentation] マクロファージと共存する脂肪細胞をLPS刺激した際に発現変動するmiRNAの網羅的解析2012

    • Author(s)
      山下明子、岩下未咲、鈴木茂樹、櫛山暁史、安孫子宣光、浅野知一郎、西村英紀
    • Organizer
      55回日本糖尿病学会
    • Place of Presentation
      横浜
    • Year and Date
      2012-05-17
    • Related Report
      2013 Final Research Report
  • [Presentation] DPP4阻害薬が炎症性サイトカインならびにインスリンシグナルへ及ぼす影響の検討2012

    • Author(s)
      新城尊徳、浅野知一郎、西村英紀、福嶋俊明、大久保博史、郭榮、岩下未咲、藤城緑、菊池貴子
    • Organizer
      55回日本糖尿病学会
    • Place of Presentation
      横浜
    • Year and Date
      2012-05-17
    • Related Report
      2013 Final Research Report
  • [Presentation] 非アルコール性脂肪性肝炎発症における肝および血球系細胞のプロリン異性化酵素Pin1の役割2012

    • Author(s)
      中津祐介、張君、郭榮、大久保博史、迫田秀之、櫛山暁史、山本屋武、鎌田英明、浅野知一郎
    • Organizer
      55回日本糖尿病学会
    • Place of Presentation
      横浜
    • Year and Date
      2012-05-17
    • Related Report
      2013 Final Research Report
  • [Presentation] 脂肪細胞分化におけるINTS6の役割2012

    • Author(s)
      大谷裕一郎、中津祐介、福嶋俊明、大久保博史、郭榮、迫田秀之、櫛山暁史、浅野知一郎
    • Organizer
      55回日本糖尿病学会
    • Place of Presentation
      横浜
    • Year and Date
      2012-05-17
    • Related Report
      2013 Final Research Report
  • [Presentation] Nedd4はインスリン受容体基質(IRS)-2を介したインスリン/インスリン様成長因子(IGF)のシグナル・生理活性を増強する2012

    • Author(s)
      福嶋俊明、吉原英人、拍野史彦、佐拍秦、田中啓二、伊藤昭博、吉田稔、中津祐介、迫田秀之、鎌田英明、高橋伸一郎、浅野知一郎
    • Organizer
      55回日本糖尿病学会
    • Place of Presentation
      横浜
    • Year and Date
      2012-05-17
    • Related Report
      2013 Final Research Report
  • [Presentation] プロリン異性化酵素Par14とPin1のインスリンシグナルと糖・脂質代謝における役割2012

    • Author(s)
      山本屋武、郭榮、張君、中津祐介、大久保博史、迫田秀之、藤城緑、門脇孝、浅野知一郎
    • Organizer
      55回日本糖尿病学会
    • Place of Presentation
      横浜
    • Year and Date
      2012-05-17
    • Related Report
      2013 Final Research Report
  • [Presentation] 非アルコール性脂肪性肝炎(NASH)の炎症における腸管およびマクロファージ由来レジスチン関連タンパクβ(RELMβ)の役割2012

    • Author(s)
      大久保博史、郭榮、福嶋俊明、櫛山暁史、菊池貴子、藤城緑、浅野知一郎
    • Organizer
      55回日本糖尿病学会
    • Place of Presentation
      横浜
    • Year and Date
      2012-05-17
    • Related Report
      2013 Final Research Report
  • [Presentation] マクロファージとの共培養系においてValsartanが脂肪細胞の遺伝子発現に与える影響2012

    • Author(s)
      藤城緑、岩下未咲、中津祐介、大久保博史、張君、大谷裕一郎、迫田秀之、櫛山暁史、菊池貴子、西村英紀、門脇孝、浅野知一郎
    • Organizer
      55回日本糖尿病学会
    • Place of Presentation
      横浜
    • Year and Date
      2012-05-17
    • Related Report
      2013 Final Research Report
  • [Presentation] 非アルコール性脂肪性肝炎発症における、肝および血球系細胞のプロリン異性化酵素Pin1の役割2012

    • Author(s)
      中津 祐介
    • Organizer
      第55回日本糖尿病学会
    • Place of Presentation
      横浜
    • Related Report
      2012 Research-status Report
  • [Presentation] 脂肪細胞分化におけるINTS6の役割2012

    • Author(s)
      大谷 裕一郎
    • Organizer
      第55回日本糖尿病学会
    • Place of Presentation
      横浜
    • Related Report
      2012 Research-status Report
  • [Presentation] Nedd4はインスリン受容体基質(IRS)-2を介したインスリン・インスリン様成長因子(IGF)のシグナル・生理作用を増強する2012

    • Author(s)
      福嶋 俊明
    • Organizer
      第55回日本糖尿病学会
    • Place of Presentation
      横浜
    • Related Report
      2012 Research-status Report
  • [Presentation] プロリン異性化酵素Par14とPin1のインスリンシグナルと糖・脂質代謝調節機構2012

    • Author(s)
      山本屋 武
    • Organizer
      第55回日本糖尿病学会
    • Place of Presentation
      横浜
    • Related Report
      2012 Research-status Report
  • [Presentation] 非アルコール性脂肪性肝炎(NASH)の発症における腸管およびマクロファージ由来レジスチン関連タンパクβ(RELMβ)の役割2012

    • Author(s)
      大久保 博史
    • Organizer
      第55回日本糖尿病学会
    • Place of Presentation
      横浜
    • Related Report
      2012 Research-status Report
  • [Patent(Industrial Property Rights)] 大腸癌、動脈硬化症、又はメタホ?リックシント? ロームの検出方法2013

    • Inventor(s)
      浅野 知一郎
    • Industrial Property Rights Holder
      国立大学法人広島大学
    • Industrial Property Rights Type
      特許
    • Acquisition Date
      2013-03-29
    • Related Report
      2013 Final Research Report
  • [Patent(Industrial Property Rights)] 大腸癌、動脈硬化症、又はメタボリックシンドロームの検出方法2012

    • Inventor(s)
      浅野 知一郎
    • Industrial Property Rights Holder
      浅野 知一郎
    • Industrial Property Rights Type
      特許
    • Filing Date
      2012-12-13
    • Acquisition Date
      2013-12-12
    • Related Report
      2013 Annual Research Report

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Published: 2013-05-31   Modified: 2019-07-29  

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