| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2014: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2013: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2012: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Outline of Final Research Achievements |
In response to hypoglycemia and hyperglycemia, hepatic glucokinase (GK) is localized to the nucleus and the cytoplasm, respectively. The intracellular localization of GK regulates the blood glucose level. In this study, I elucidate that the glucose sensing system or the GK transport mechanism in hepatocytes is impaired in HEK293 cells derived from human kidney. Moreover, antibodies were raised against the proteins involved in GK transport to clarify the protein-protein interaction with GK
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