| Project/Area Number |
24659469
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Hematology
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| Research Institution | Sojo University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
MIYAHARA Kohji 崇城大学, 生物生命学部, 准教授 (40325155)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2014: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2013: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | スフィンゴミエリン / スフィンゴ脂質 / セラミド / スフィンゴミエリン合成酵素 / スフィンゴシン1-リン酸 / S1Pリアーゼ / スフィンゴミエリナーゼ / 線虫 / スフィンゴシン１-リン酸 / スフィンゴ脂質セラミド / スフィンゴシン / スフィンゴシン1リン酸 / 血小板 |
|---|
| Outline of Final Research Achievements |
Sphingolipids are important components of cellular membranes and act as signaling molecules such as ceramide and sphingosine 1-phosphate, potentially regulating cellular processes such as growth, differentiation, adhesion, migration, autophagy, and apoptosis. Here, we have investigated the biological function of sphingolipid metabolic enzymes by using mice and C. elegans mutants deficient for these enzymes.
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