Sphingolipid metabolism in thrombosis and hemostasis
Project/Area Number |
24659469
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Research Category |
Grant-in-Aid for Challenging Exploratory Research
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Allocation Type | Multi-year Fund |
Research Field |
Hematology
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Research Institution | Sojo University |
Principal Investigator |
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Co-Investigator(Kenkyū-buntansha) |
MIYAHARA Kohji 崇城大学, 生物生命学部, 准教授 (40325155)
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Project Period (FY) |
2012-04-01 – 2015-03-31
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Project Status |
Completed (Fiscal Year 2014)
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Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2014: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2013: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
|
Keywords | スフィンゴミエリン / スフィンゴ脂質 / セラミド / スフィンゴミエリン合成酵素 / スフィンゴシン1-リン酸 / S1Pリアーゼ / スフィンゴミエリナーゼ / 線虫 / スフィンゴシン1-リン酸 / スフィンゴ脂質セラミド / スフィンゴシン / スフィンゴシン1リン酸 / 血小板 |
Outline of Final Research Achievements |
Sphingolipids are important components of cellular membranes and act as signaling molecules such as ceramide and sphingosine 1-phosphate, potentially regulating cellular processes such as growth, differentiation, adhesion, migration, autophagy, and apoptosis. Here, we have investigated the biological function of sphingolipid metabolic enzymes by using mice and C. elegans mutants deficient for these enzymes.
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Report
(4 results)
Research Products
(26 results)
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[Journal Article] Hot Topics 20122013
Author(s)
武谷浩之
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Journal Title
Japanese Journal of Thrombosis and Hemostasis
Volume: 24
Issue: 1
Pages: 60-67
DOI
NAID
ISSN
0915-7441, 1880-8808
Related Report
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[Journal Article] Regulation of cell migration by sphingomyelin synthases : sphingomyelin in lipid rafts decreases responsiveness to signaling by the CXCL12/CXCR4 pathway2012
Author(s)
Asano S, Kitatani K, Taniguchi M, Hashimoto M, Zama K, Mitsutake S, Igarashi Y, Takeya H, Kigawa J, Hayashi A, Umehara H and Okazaki T
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Journal Title
Molecular and cellular biology
Volume: 32
Issue: 16
Pages: 3242-3252
DOI
Related Report
Peer Reviewed
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[Journal Article] Regulation of autophagy and its associated cell death by sphingolipid rheostat: Reciprocal role in ceramide and sphingosine-1-phosphate in the mTOR pathway2012
Author(s)
Taniguchi M., Kitatani K., Kondo T., Hashimoto-Nishimura M., Asano S., Hayashi A., Mitsutake S., Igarashi Y., Umehara H., Takeya H., Kigawa J. and Okazaki T.
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Journal Title
J. Biol. Chem
Volume: 287
Issue: 47
Pages: 39898-39910
DOI
Related Report
Peer Reviewed
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[Presentation] スフィンゴ脂質の代謝と機能2014
Author(s)
武谷浩之
Organizer
岡山県医用工学研究会シンポジウム
Place of Presentation
岡山大学鹿田キャンパス(岡山県岡山市)
Year and Date
2014-10-10
Related Report
Invited
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