| Project/Area Number |
24659477
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Infectious disease medicine
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| Research Institution | Tohoku University |
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Principal Investigator |
ISHII Keiko 東北大学, 医学(系)研究科(研究院), 准教授 (00291253)
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| Co-Investigator(Renkei-kenkyūsha) |
KAWAKAMI Kazuyoshi 東北大学, 大学院医学系研究科, 教授 (10253973)
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | クリプトコックス・ガッティ / 高病原性 / オバルブミン / T細胞サブセット / 免疫応答性 / オバルブミン（OVA） |
|---|
| Research Abstract |
The aim of this study is to clarify the protective immune responses to a highly pathogenic Cryptococcus gattii. During the study period, we found that highly pathogenic strains with thick capsule escaped from the recognition by dendritic cells. We also successfully transformed several kinds of cryptococcal strains with Gallus ovalbumin (OVA) gene by using the biolistic method. With the transformed cryptococcal strains and transgenic (Tg) mice expressing OVA-specific T cell receptors, we built a novel assay system for studies on protective immune response to C. gattii.
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