Molecular evolutionary analysis on the origin and etiology of schizophrenia

• Project/Area Number: 24659536
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Single-year Grants
• Research Field: Psychiatric science
• Research Institution: University of Tsukuba
• Principal Investigator: ARINAMI Tadao 筑波大学, 医学医療系, 教授 (10212648)
• Project Period (FY): 2012-04-01 – 2014-03-31
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000); Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
• Keywords: 臨床精神分子遺伝学 / 進化医学 / 統合失調症 / 分子進化

Research Abstract

Schizophrenia, one of the most detrimental common psychiatric disorders, occurs in all human ethnic groups but not in any animal species, indicating that it emerged during human evolution. To clarify the relation between schizohrenia and the architecture of human genome, the present study compared allele frequencies of polymorphisms associated with schizophrenia among major ethnic groups, Neandertals and Denisovans. Increased frequencies of the risk alleles of the polymorphisms associated with schizohrenia were found significantly in the Europeans and Asians, compared with Sub-Saharan African, Neandertals and Denisovans. These findings suggest that risk alleles have functioned preferentially during human evolution, particularly after "out of Africa", indicating positive selection of schizophrenia associated genes during modern human evolution.

Research Products

• [Journal Article] Experimental evidence for the involvement of PDLIM5 in mood disorders in hetero knockout mice (2013)
  • Author(s): Horiuchi Y, Ishikawa M, Kaito N, Iijima Y, Tanabe Y, Ishiguro H, Arinami T
  • Journal Title: PLoS One Volume: 8(4)
  • NAID: 120007136961
  • Peer Reviewed
• [Journal Article] DPP6 as a candidate gene for neuroleptic-induced tardive dyskinesia (2013)
  • Author(s): Tanaka S, Syu A, Ishiguro H, Inada T, Horiuchi Y, Ishikawa M, Koga M, Noguchi E, Ozaki N, Someya T, Kakita A, Takahashi H, Nawa H, Arinami T
  • Journal Title: Pharmacogenomics J Volume: 13(1) Pages: 27-34
  • Peer Reviewed
• [Journal Article] DPP6 as a candidate gene for neuroleptic-induced tardive dyskinesia. (2013)
  • Author(s): Tanaka S, Syu A, Ishiguro H, Inada T, Horiuchi Y, Ishikawa M, Koga M, Noguchi E, Ozaki N, Someya T, Kakita A, Takahashi H, Nawa H, Arinami T.
  • Journal Title: Pharmacogenomics J. Volume: 13 Pages: 27-34
  • Peer Reviewed
• [Presentation] 日本人統合失調症罹患同胞対家系における連鎖領域の変異探索 (2013)
  • Author(s): 朝倉明果、鈴木千裕、飯嶋良味、野口恵美子、有波忠雄
  • Organizer: 日本人類遺伝学会第58回大会
  • Place of Presentation: 仙台
  • Year and Date: 2013-11-21
• [Presentation] 日本人統合失調症罹患同胞対家系における連鎖領域の変異探索 (2013)
  • Author(s): 朝倉明果、鈴木千裕、飯嶋良味、野口恵美子、有波忠雄
  • Organizer: 日本人類遺伝学会 第58回大会
  • Place of Presentation: 江陽グランドホテル（宮城県仙台市）