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New cancer treatment focusing on genetic instability of the cancer stem cell

Research Project

Project/Area Number 24659614
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeSingle-year Grants
Research Field Digestive surgery
Research InstitutionKyushu University

Principal Investigator

MAEHARA Yoshihiko  九州大学, 医学(系)研究科(研究院), 教授 (80165662)

Project Period (FY) 2012-04-01 – 2014-03-31
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywords染色体不安定性 / 酸化ストレス / BuBR1 / p53 / がん幹細胞 / LgR5 / LGR5 / 遺伝子不安定性 / 癌幹細胞 / CD44
Research Abstract

The cancer stem cell remains to be resistant to the treatment such as chemotherapy or the radiation. We can propose a new treatment to reduce recurrence and metastasis by targetting the cancer stem cell. Because a cancer is exposed to hypoxia and chemical irritation partially, some cells become a stem like cell and become to generate genetic instability.
In our experiment,oxidative stress (OS) causes DNA damage and chromosome instability that may lead to carcinogenesis. OS is also suggested to contribute to an increase in aneuploid cells. However, it is not clear how OS is involved in the regulation of SAC and contributes to carcinogenesis associated with aneuploidy. Here we show that an oxidant (KBrO3) activated the p53 signaling pathway and suppressed the expression of SAC factors, BubR1, and Mad2, in human diploid fibroblast MRC5 cells. This suppression was dependent on functional p53 and reactive oxygen species.

Report

(3 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • Research Products

    (58 results)

All 2014 2013 2012

All Journal Article (56 results) (of which Peer Reviewed: 8 results,  Open Access: 1 results) Presentation (2 results)

  • [Journal Article] Prognostic impact of programmed cell death 1 ligand 1 expression in human leukocyte antigen class I-positive hepatocellular carcinoma after curative hepatectomy2014

    • Author(s)
      Umemoto Y, Okano S, Matsumoto Y, Nakagawara H, Matono R, Yoshiya S, Yamashita YI, Yoshizumi T, Ikegami T, Soejima Y, Harada M, Aishima S, Oda Y, Shirabe K, Maehara Y
    • Journal Title

      J Gastroenterol

    • Related Report
      2013 Final Research Report
  • [Journal Article] A novel serum marker, glycosylated Wisteria floribunda agglutinin-positive Mac-2 binding protein (WFA-M2BP), for assessing liver fibrosis2014

    • Author(s)
      Toshima T, Shirabe K, Ikegami T, Yoshizumi T, Kuno A, Togayachi A, Gotoh M, Narimatsu H, Korenaga M, Mizokami M, Nishie A, Aishima S, Maehara Y
    • Journal Title

      J Gastroenterol

    • Related Report
      2013 Final Research Report
  • [Journal Article] Allelic Imbalance at an 8q24 Oncogenic SNP is Involved in Activating MYC in Human Colorectal Cancer2014

    • Author(s)
      Sugimachi K, Niida A, Yamamoto K, Shimamura T, Imoto S, Iinuma H, Shinden Y, Eguchi H, Sudo T, Watanabe M, Tanaka J, Kudo S, Hase K, Kusunoki M, Yamada K, Shimada Y, Sugihara K, Maehara Y, Miyano S, Mori M, Mimori K
    • Journal Title

      Ann Surg Oncol

    • Related Report
      2013 Final Research Report
  • [Journal Article] Phase II Study of Docetaxel and S-1 (DS) as Neoadjuvant Chemotherapy for Clinical Stage III Resectable Gastric Cancer2014

    • Author(s)
      Oki E, Emi Y, Kusumoto T, Sakaguchi Y, Yamamoto M, Sadanaga N, Shimokawa M, Yamanaka T, Saeki H, Morita M, Takahashi I, Hirabayashi N, Sakai K, Orita H, Aishima S, Kakeji Y, Yamaguchi K, Yoshida K, Baba H, Maehara Y
    • Journal Title

      Ann Surg Oncol

    • Related Report
      2013 Final Research Report
  • [Journal Article] Rad51 expression is a useful predictive factor for the efficacy of neoadjuvant chemoradiotherapy in squamous cell carcinoma of the esophagus2014

    • Author(s)
      Nakanoko T, Saeki H, Morita M, Nakashima Y, Ando K, Oki E, Ohga T, Kakeji Y, Toh Y, Maehara Y
    • Journal Title

      Ann Surg Oncol

      Volume: 21 Pages: 597-604

    • Related Report
      2013 Final Research Report
  • [Journal Article] Balloon-occluded retrograde transvenous obliteration is feasible for prolonged portosystemic shunts after living donor liver transplantation2014

    • Author(s)
      Nagao Y, Akahoshi T, Uehara H, Hashimoto N, Kinjo N, Kawanaka H, Tomikawa M, Uchiyama H, Yoshizumi T, Soejima Y, Shirabe K, Maehara Y
    • Journal Title

      Surg Today

      Volume: 44 Pages: 633-639

    • Related Report
      2013 Final Research Report
  • [Journal Article] Technical improvement of total pharyngo-laryngo-esophagectomy for esophageal cancer and head and neck cancer2014

    • Author(s)
      Morita M, Saeki H, Ito S, Ikeda K, Yamashita N, Ando K, Hiyoshi Y, Ida S, Tokunaga E, Uchiyama H, Oki E, Ikeda T, Yoshida S, Nakashima T, Maehara Y
    • Journal Title

      Ann Surg Oncol

      Volume: 21 Pages: 1671-1677

    • Related Report
      2013 Final Research Report
  • [Journal Article] Gender differences in prognosis after esophagectomy for esophageal cancer2014

    • Author(s)
      Morita M, Otsu H, Kawano H, Kasagi Y, Kimura Y, Saeki H, Ando K, Ida S, Oki E, Tokunaga E, Ikeda T, Kusumoto T, Maehara Y
    • Journal Title

      Surg Today

      Volume: 44 Pages: 505-512

    • Related Report
      2013 Final Research Report
  • [Journal Article] Prognostic and Therapeutic Implications of Aromatase Expression in Lung Adenocarcinomas with EGFR mutations2014

    • Author(s)
      Kohno M, Okamoto T, Suda K, Shimokawa M, Kitahara H, Shimamatsu S, Konishi H, Yoshida T, Takenoyama M, Yano T, Maehara Y
    • Journal Title

      Clin Cancer Res

    • Related Report
      2013 Final Research Report
  • [Journal Article] Significance of preoperative evaluation of the right gastroepiploic artery graft to the coronary artery in patients undergoing abdominal surgery2014

    • Author(s)
      Ito S, Yamaguchi S, Saeki H, Oki E, Tayama E, Ikejiri K, Morita M, Maehara Y
    • Journal Title

      World JSurg

      Volume: 38 Pages: 1051-1057

    • Related Report
      2013 Final Research Report
  • [Journal Article] Splenic volume may be a useful indicator of the protective effect of bevacizumab against oxaliplatin-induced hepatic sinusoidal ostruction syndrome2014

    • Author(s)
      Imai K, Emi Y, Iyama KI, Beppu T, Ogata Y, Kakeji Y, Samura H, Oki E, Akagi Y, Maehara Y, Baba H
    • Journal Title

      Ear JSurg Oncol

      Volume: 40 Pages: 559-566

    • Related Report
      2013 Final Research Report
  • [Journal Article] A high MELD score, combined with the presence of hepatitis C, is associated with a poor prognosis in living donor liver transplantation2014

    • Author(s)
      Ikegami T, Shirabe K, Yoshiya S, Yoshizumi T, Yamashita Y, Harimoto N, Toshima T, Uchiyama H, Soejima Y, Maehara Y
    • Journal Title

      Surg Today

      Volume: 44 Pages: 233-240

    • Related Report
      2013 Final Research Report
  • [Journal Article] Surgical resection of hypopharynx and cervical esophageal cancer with a history of esophagectomy for thoracic esophageal cancer2014

    • Author(s)
      Ida S, Morita M, Hiyoshi Y, Ikeda K, Ando K, Kimura Y, Saeki H, Oki E, Kusumoto T, Yoshida S, Nakashima T, Watanabe M, Baba H, Maehara Y
    • Journal Title

      Ann Surg Oncol

      Volume: 21 Pages: 1175-1181

    • Related Report
      2013 Final Research Report
  • [Journal Article] Contribution of Aurora-A and -B expression to DNA aneuploidy in gastric cancers2014

    • Author(s)
      Honma K, Nakanishi R, Nakanoko T, Ando K, Saeki H, Oki E, Iimori M, Kitao H, Kakeji Y, Maehara Y
    • Journal Title

      Surg Today

      Volume: 44 Pages: 454-461

    • Related Report
      2013 Final Research Report
  • [Journal Article] Impact of GATA-3 and FOXA1 expression in patients with hormone receptor-positive/HER2-negative breast cancer2014

    • Author(s)
      Hisamatsu Y, Tokunaga E, Yamashita N, Akiyoshi S, Okada S, Nakashima Y, Taketani K, Aishima S, Oda Y, Morita M, Maehara Y
    • Journal Title

      Breast Cancer

    • Related Report
      2013 Final Research Report
  • [Journal Article] Mortalin is a prognostic factor of gastric cancer with normal p53 function2014

    • Author(s)
      Ando K, Oki E, Zhao Y, Ikawa-Yoshida A, Kitao H, Saeki H, Kimura Y, Ida S, Morita M, Kusumoto T, Maehara Y
    • Journal Title

      Gastric Cancer

      Volume: 17 Pages: 255-262

    • Related Report
      2013 Final Research Report
  • [Journal Article] Mortalin is a prognostic factor of gastric cancer with normal p53 function.2014

    • Author(s)
      Ando K., Oki E., Zhao Y., Yoshida A., Kitao H., Saeki H., Kimura Y., Ida S., Morita M., Kusumoto T., Maehara Y.
    • Journal Title

      Gastric Cancer

      Volume: 17(2) Issue: 2 Pages: 255-262

    • DOI

      10.1007/s10120-013-0279-1

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Rendezvous ductoplasty for biliary anastomotic stricture after living-donor liver transplantation2013

    • Author(s)
      Yoshiya S, Shirabe K, Matsumoto Y, Ikeda T, Soejima Y, Yoshizumi T, Uchiyama H, Ikegami T, Harimoto N, Maehara Y
    • Journal Title

      Transplantation

      Volume: 95 Pages: 1278-1283

    • Related Report
      2013 Final Research Report
  • [Journal Article] DVC1-0101 to treat peripheral arterial disease : a Phase I/IIa open-label dose-escalation clinical trial2013

    • Author(s)
      Yonemitsu Y, Matsumoto T, Itoh H, Okazaki J, Uchiyama M, Yoshida K, Onimaru M, Onohara T, Inoguchi H, Kyuragi R, Shimokawa M, Ban H, Tanaka M, Inoue M, Shu T, Hasegawa M, Nakanishi Y, Maehara Y
    • Journal Title

      Mol Ther

      Volume: 21 Pages: 707-714

    • Related Report
      2013 Final Research Report
  • [Journal Article] Surgical outcomes of pancreaticoduodenectomy for periampullary tumors in elderly patients2013

    • Author(s)
      Yamashita Y, Shirabe K, Tsujita E, Takeishi K, Ikeda T, Yoshizumi T, Furukawa Y, Ishida T, Maehara Y
    • Journal Title

      Langenbecks Arch Surg

      Volume: 398 Pages: 539-545

    • Related Report
      2013 Final Research Report
  • [Journal Article] Third or more repeat hepatectomy for recurrent hepatocellular carcinoma2013

    • Author(s)
      Yamashita Y, Shirabe K, Tsuijita E, Takeishi K, Ikegami T, Yoshizumi T, Soejima Y, Ikeda T, Utsunomiya T, Maehara Y
    • Journal Title

      Surgery

      Volume: 154 Pages: 1038-1045

    • Related Report
      2013 Final Research Report
  • [Journal Article] Risk factors for recurrence after curative resection of hepatitis C-related hepatocellular carcinoma in patients without postoperative interferon therapy2013

    • Author(s)
      Yamashita Y, Shirabe K, Toshima T, Tsuijita E, Takeishi K, Harimoto N, Ikegami T, Yoshizumi T, Ikeda T, Soejima Y, Maehara Y
    • Journal Title

      Hepatol Res

      Volume: 43 Pages: 1313-1320

    • Related Report
      2013 Final Research Report
  • [Journal Article] Vimentin as a poor prognostic factor for triple-negative breast cancer2013

    • Author(s)
      Yamashita N, Tokunaga E, Kitao H, Hisamatsu Y, Taketani K, Akiyoshi S, Okada S, Aishima S, Morita M, Maehara Y
    • Journal Title

      J Cancer Res Clin Oncol

      Volume: 139 Pages: 739-746

    • Related Report
      2013 Final Research Report
  • [Journal Article] Rad9, Rad17, TopBP1 and claspin play essential roles in heat-induced activation of ATR kinase and heat tolerance2013

    • Author(s)
      Tuul M, Kitao H, Iimori M, Matsuoka K, Kiyonari S, Saeki H, Oki E, Morita M, Maehara Y
    • Journal Title

      PLoS One

      Volume: 8

    • Related Report
      2013 Final Research Report
  • [Journal Article] Image-guided laparoscopic surgery in an open MRI operating theater2013

    • Author(s)
      Tsutsumi N, Tomikawa M, Uemura M, Akahoshi T, Nagao Y, Konishi K, Ieiri S, Hong J, Maehara Y, Hashizume M
    • Journal Title

      Surg Endosc

      Volume: 27 Pages: 2178-2184

    • Related Report
      2013 Final Research Report
  • [Journal Article] Aurora-B overexpression is correlated with aneuploidy and poor prognosis in non-small cell lung cancer2013

    • Author(s)
      Takeshita M, Koga T, Takayama K, Ijichi K, Yano T, Maehara Y, Nakanishi Y, Sueishi K
    • Journal Title

      Lung Cancer

      Volume: 80 Pages: 85-90

    • Related Report
      2013 Final Research Report
  • [Journal Article] Aberrant Expression of Plastin-3 Via Copy Number Gain Induces the Epithelial-Mesenchymal Transition in Circulating Colorectal Cancer Cells2013

    • Author(s)
      Sugimachi K, Yokobori T, Iinuma H, Ueda M, Ueo H, Shinden Y, Eguchi H, udo T, Suzuki A, Maehara Y, Mori M,Mimori K
    • Journal Title

      Ann Surg Oncol

    • Related Report
      2013 Final Research Report
  • [Journal Article] Multimodal treatment strategy for clinical T3 thoracic esophageal cancer2013

    • Author(s)
      Saeki H, Morita M, Tsuda Y, Hidaka G, Kasagi Y, Kawano H, Otsu H, Ando K, Kimura Y, Oki E, Kusumoto T, Maehara Y
    • Journal Title

      Ann Surg Oncol

      Volume: 20 Pages: 4267-4273

    • Related Report
      2013 Final Research Report
  • [Journal Article] Impact of second-line and later cetuximab-containing therapy and KRAS genotypes in patients with metastatic colorectal cancer : a multicenter study in Japan2013

    • Author(s)
      Saeki H, Emi Y, Kumashiro R, Otsu H, Kawano H, Ando K, Ida S, Kimura Y, Tokunaga E, Oki E, Morita M, Shimokawa M, Maehara Y
    • Journal Title

      Surg Today

    • Related Report
      2013 Final Research Report
  • [Journal Article] Phase II trial of alternating mFOLFOX6 and FOLFIRI regimens in the first-line treatment for unresectable or metastatic colorectal cancer (KSCC0701)2013

    • Author(s)
      Oki E, Emi Y, Akagi Y, Tokunaga S, Sadanaga N, Tanaka T, Ogata Y, Saeki H, Kakeji Y, Baba H, Nishimaki T, Natsugoe S, Shirouzu K, Maehara Y
    • Journal Title

      Oncology

      Volume: 84 Pages: 233-239

    • Related Report
      2013 Final Research Report
  • [Journal Article] Dedifferentiated liposarcoma of the spermatic cord with a hemangioendothelioma-like component : a case report and review of the literature2013

    • Author(s)
      Okano S, Yamamoto H, Kono S, Fujii H, Shirabe K, Maehara Y, Oda Y
    • Journal Title

      Pathol Res Pract

      Volume: 209 Pages: 596-604

    • Related Report
      2013 Final Research Report
  • [Journal Article] CD4 T cell-mediated masking effects of the immunogenicity of tumor-associated antigens are qualitatively and quantitatively different depending on the individual antigens2013

    • Author(s)
      Okano S, Matsumoto Y, Yoshiya S, Yamashita Y, Harimoto N, Ikegami T, Shirabe K, Harada M, Yoshikai Y, Maehara Y
    • Journal Title

      Fukuoka Igaku Zasshi

      Volume: 104 Pages: 1-14

    • NAID

      120005227183

    • Related Report
      2013 Final Research Report
  • [Journal Article] Fas-deficient fully allogeneic dendritic cells administered via an intratumoral injection route show efficient antitumor effects in murine models2013

    • Author(s)
      Okano S, Kondoh H, Toshima T, Nakagawara H, Yoshizumi T, Soejima Y. Shirabe K, Harada M, Yoshikai Y, Maehara Y
    • Journal Title

      Fukuoka Igaku Zasshi

      Volume: 104 Pages: 15-26

    • NAID

      120005227184

    • Related Report
      2013 Final Research Report
  • [Journal Article] Podoplanin is expressed at the invasive front of esophageal squamous cell carcinomas and is involved in collective cell invasion2013

    • Author(s)
      Nakashima Y, Yoshinaga K, Kitao H, Ando K, Kimura Y, Saeki H, Oki E, Morita M, Kakeji Y, Hirahashi M, Oda Y, Maehara Y
    • Journal Title

      Cancer Sci

      Volume: 104 Pages: 1718-1725

    • Related Report
      2013 Final Research Report
  • [Journal Article] Advances in esophageal surgery in elderly patients with thoracic esophageal cancer2013

    • Author(s)
      Morita M, Otsu H, Kawano H, Kumashiro R, Taketani K, Kimura Y, Saeki H, Ando K, Ida S, Oki E, Tokunaga E, Ikeda T, Kusumoto T, Maehara Y
    • Journal Title

      Anticancer Res

      Volume: 33 Pages: 1641-1647

    • Related Report
      2013 Final Research Report
  • [Journal Article] Surgical resection for esophageal cancer synchronously or metachronously associated with head and neck cancer2013

    • Author(s)
      Morita M, Kawano H, Otsu H, Kimura Y, aeki H, Ando K, Ida S, Oki E, Ikeda T, Kusumoto T, Fukushima J, Nakashima T, Maehara Y
    • Journal Title

      Ann Surg Oncol

      Volume: 20 Pages: 2434-2439

    • Related Report
      2013 Final Research Report
  • [Journal Article] Decreased roundabout 1 expression promotes development of intrahepatic cholangiocarcinoma2013

    • Author(s)
      Mano Y, Aishima S, Fukuhara T, Tanaka Y, Kubo Y, Motomura T, Toshima T, Iguchi T, Shirabe K, Maehara Y, Oda Y
    • Journal Title

      Hum Pathol

      Volume: 44 Pages: 2419-2426

    • Related Report
      2013 Final Research Report
  • [Journal Article] Tumor-associated macrophage promotes tumor progression via STAT3 signaling in hepatocellular carcinoma2013

    • Author(s)
      Mano Y, Aishima S, Fujita N, Tanaka Y, Kubo Y, Motomura T, Taketomi A, Shirabe K, Maehara Y, Oda Y
    • Journal Title

      Pathobiology

      Volume: 80 Pages: 146-154

    • Related Report
      2013 Final Research Report
  • [Journal Article] Endovascular aneurysm repair for an abdominal aortic aneurysm and a left ruptured common iliac artery aneurysm in a patient with hepatocellular carcinoma : report of a case2013

    • Author(s)
      Kyuragi R, Matsumoto T, Okadome J, Kawakubo E, Homma K, Iwasa K, Guntani A, Okazaki J, Maehara Y
    • Journal Title

      Surg Today

    • Related Report
      2013 Final Research Report
  • [Journal Article] Hepatic interferon-gamma-induced protein-10 expression is more strongly associated with liver fibrosis than interleukin-28B single nucleotide polymorphisms in hepatocellular carcinoma resected patients with chronic hepatitis C2013

    • Author(s)
      Konishi H, Shirabe K, Yoshiya S, Ikeda T, Ikegami T, Yoshizumi T, Ikawa-Yoshida A, Motomura T, Fukuhara T, Maehara Y
    • Journal Title

      Hepatol Res

      Volume: 43 Pages: 1139-1147

    • Related Report
      2013 Final Research Report
  • [Journal Article] Hepatic vein waveform and splenomegaly predict improvement of prothrombin time after splenectomy in hepatitis C virus-related cirrhotic patients2013

    • Author(s)
      Kinjo N, Nagao Y, Akahoshi T, Masahiro K, Hashimoto N, Uehara H, Kawanaka H, Tomikawa M, Shirabe K, Hashizume M, Maehara Y
    • Journal Title

      Hepatol Res

      Volume: 43 Pages: 933-941

    • Related Report
      2013 Final Research Report
  • [Journal Article] Liver regeneration and venous collateral formation in the right lobe living-donor remnant : segmental volumetric analysis and three-dimensional visualization2013

    • Author(s)
      Kayashima H, Shirabe K, Morita K, Hashimoto N, Ikegami T, Yoshizumi T, Soejima Y, Maehara Y
    • Journal Title

      Transplantation

      Volume: 95 Pages: 353-360

    • Related Report
      2013 Final Research Report
  • [Journal Article] Use of the SAND balloon catheter in single-incision laparoscopic cholecystectomy for acute cholecystitis2013

    • Author(s)
      Ikegami T, Shirabe K, Yoshizumi T, Kayashima H, Maehara Y
    • Journal Title

      Asian JEndosc Surg

      Volume: 6 Pages: 134-136

    • Related Report
      2013 Final Research Report
  • [Journal Article] Obstructing spontaneous major shunt vessels is mandatory to keep adequate portal inflow in living-donor liver transplantation2013

    • Author(s)
      Ikegami T, Shirabe K, Nakagawara H, Yoshizumi T, Toshima T, Soejima Y, Uchiyama H, Yamashita Y, Harimoto N, Maehara Y
    • Journal Title

      Transplantation

      Volume: 95 Pages: 1270-1277

    • Related Report
      2013 Final Research Report
  • [Journal Article] Contribution of BubR1 to oxidative stress-induced aneuploidy in p53-deficient cells2013

    • Author(s)
      Ikawa-Yoshida A, Ando K, Oki E, Saeki H, Kumashiro R, Taketani K, Ida S, Tokunaga E, Kitao H, Morita M, Maehara Y
    • Journal Title

      Cancer Med

      Volume: 2 Pages: 447-456

    • Related Report
      2013 Final Research Report
  • [Journal Article] Expression of Brachyury gene is a significant prognostic factor for primary lung carcinoma2013

    • Author(s)
      Haro A, Yano T, Kohno M, Yoshida T, Koga T, Okamoto T, Takenoyama M, Maehara Y
    • Journal Title

      Ann Surg Oncol

      Volume: 20 Suppl 3

    • Related Report
      2013 Final Research Report
  • [Journal Article] Sarcopenia as a predictor of prognosis in patients following hepatectomy for hepatocellular carcinoma2013

    • Author(s)
      Harimoto N, Shirabe K, Yamashita YI, Ikegami T, Yoshizumi T, Soejima Y, Ikeda T, Maehara Y, Nishie A, Yamanaka T
    • Journal Title

      Br JSurg

      Volume: 100 Pages: 1523-1530

    • Related Report
      2013 Final Research Report
  • [Journal Article] Contribution of BubR1 to oxidative stress-induced aneuploidy in p53-deficient cells.2013

    • Author(s)
      Ikawa-Yoshida A., Ando K., Oki E., Saeki H., Kumashiro R., Taketani K., Ida S., Tokunaga E., Kitao H., Morita M., Maehara Y.
    • Journal Title

      Cancer Medicine

      Volume: 2(4) Issue: 4 Pages: 447-456

    • DOI

      10.1002/cam4.101

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Podoplanin is expressed at the invasive front of esophageal squamous cell carcinomas and is involved in collective cell invasion.2013

    • Author(s)
      Nakashima Y, Yoshinaga K, Kitao H, Ando K, Kimura Y, Saeki H, Oki E, Morita M, Kakeji Y, Hirahashi M, Oda Y, Maehara Y
    • Journal Title

      Cancer Sci

      Volume: 104 Issue: 12 Pages: 1718-1725

    • DOI

      10.1111/cas.12286

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Prognostic relevance of KRAS and BRAF mutations in Japanese patients with colorectal cancer2013

    • Author(s)
      Nakanishi R
    • Journal Title

      Int J Clin Oncol

      Volume: Nov 29

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Vimentin as a poor prognostic factor for triple-negative breast cancer.2013

    • Author(s)
      Yamashita N
    • Journal Title

      J Cancer Res Clin Oncol

      Volume: Jan 26

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Technical evolution of laparoscopic hepatic resection : a single institutional experience2012

    • Author(s)
      Soejima Y, Ikegami T, Ijichi H, Ikeda T, Shirabe K, Yoshizumi T, Uchiyama H, Yamashita Y, Harimoto N, Toshima T, Matsuura H, Okadome K, Maehara Y
    • Journal Title

      Fukuoka Igaku Zasshi

      Volume: 103 Pages: 226-232

    • NAID

      120005068814

    • Related Report
      2013 Final Research Report
  • [Journal Article] Surgical management of hepatocellular carcinoma in Child-Pugh class B cirrhotic patients : hepatic resection and/or microwave coagulation therapy versus living donor liver transplantation2012

    • Author(s)
      Harada N, Shirabe K, Ikeda Y, Korenaga D, Takenaka K, Maehara Y
    • Journal Title

      Ann Transplant

      Volume: 17 Pages: 11-20

    • Related Report
      2013 Final Research Report
  • [Journal Article] CtIP- and ATR-dependent FANCJ phosphorylation in response to DNA strand breaks mediated by DNA replication2012

    • Author(s)
      Sakasai R
    • Journal Title

      Genes Cells

      Volume: 17 Pages: 962-970

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] FANCJ expression predicts the response to 5-fluorouracil-based chemotherapy in MLH1-proficient colorectal cancer2012

    • Author(s)
      Nakanishi R
    • Journal Title

      Ann Surg Oncol

      Volume: 19 Pages: 3627-3635

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Clinical aspect and molecular mechanism of DNA aneuploidy in gastric cancers.2012

    • Author(s)
      Oki E
    • Journal Title

      J Gastroenterol

      Volume: 47 Pages: 351-358

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Presentation] 胃癌における細胞周期の制御因子Plk1過剰発現と染色体不安定性の関連2012

    • Author(s)
      大津 甫他
    • Organizer
      日本消化器外科学会総会
    • Place of Presentation
      富山
    • Related Report
      2012 Research-status Report
  • [Presentation] 胃癌における紡錘体形成チェックポイントタンパク質BUBR1発現およびDNA aneuploidyの意義2012

    • Author(s)
      安藤幸滋他
    • Organizer
      日本外科学会定期学術集会
    • Place of Presentation
      千葉
    • Related Report
      2012 Research-status Report

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Published: 2013-05-31   Modified: 2019-07-29  

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