The role of autophagy in tumor-stromal cell interaction

• Project/Area Number: 24659615
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Single-year Grants
• Research Field: Digestive surgery
• Research Institution: Kyushu University
• Principal Investigator: NAKATA Kohei 九州大学, 大学病院, 助教 (30419569)
• Co-Investigator(Kenkyū-buntansha): SHIRAHANA Kengo 九州大学, 医学研究院, 共同研究員 (10529803)
• Project Period (FY): 2012-04-01 – 2014-03-31
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000); Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000); Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
• Keywords: 膵臓癌 / オートファジー / 癌間質相互作用 / 膵星細胞 / 癌

Research Abstract

We established pancreatic stellate cells from pancreatic cancer tissue obtained during surgery. We identified the autophagy levels in each pancreatic stellate cells and found the levels were different in each cells. We also found the invasiveness of pancreatic cancer cell lines were increased with co-culture with pancreatic stellate cells and identified that its invasiveness was decreased with 3MA.

Research Products

• [Journal Article] MicroRNA-373 is down regulated in pancreatic cancer and inhibits cancer cell incasion (2014)
  • Author(s): Nakata K, Ohuchida K, Mizumoto K, Aishima S, Nagai E, Oda Y and Tanaka M
  • Journal Title: Annals of Surgical Oncology Volume: (in press)
• [Journal Article] laparoscopic surgery for gastric intestinal stromal tumor is feasible irrespective of tumor size (2014)
  • Author(s): Kasetsermwiriya W, Nagai E, Nakata K, et al
  • Journal Title: J laparoendosc Adv Surg Tech A Volume: 24(3) Pages: 123-9
• [Journal Article] Micro RNA-373 is Down-regulated in Pancreatic Cancer and Inhibits Cancer Cell Invasion (2014)
  • Author(s): Nakata K, Ohuchida K, Mizumoto K, Aishima S, Oda Y, Nagai E, Tanaka M
  • Journal Title: Ann Surg Oncol Volume: 21 Issue: S4 Pages: 564-574
  • DOI: 10.1245/s10434-014-3676-8
  • Peer Reviewed
• [Journal Article] Feasibility and safety of intracorporeal esophagojejunostomy after laparoscopic total gastrectomy : Inverted T-shaped anastomosis using linear staplers (2013)
  • Author(s): Nagai E, Ohuchida K, Nakata K, Toma H, Tanaka M
  • Journal Title: Surgery Volume: 153(5) Pages: 732-8
• [Journal Article] Insulin-like growth factor II messenger RNA-binding protein-3 is a valuable diagnostic and prognostic marker of intraductal papillary mucinous neoplasm (2013)
  • Author(s): Morimatsu K, Aishima S, Yamamoto H, Hayashi A, Nakata K, Oda Y, Shindo K, Fujino M, Tanaka M, Oda Y
  • Journal Title: Hum Pathol Volume: 44(9) Pages: 1714-21
• [Presentation] Salinomycin induced Autophagy and is Related with its Killing Effect for Pancreatic Cells (2013)
  • Author(s): K Nakata, et al
  • Organizer: American Pancreatic Association, 44th Annual Meeting
  • Place of Presentation: Miami
  • Year and Date: 2013-10-31
• [Presentation] Salinomycin induced autophagy in pancreatic cancer cells and related with its cell killing effect
  • Author(s): Nakata K et al
  • Organizer: 44th Annual meeting of the American pancreatic association
  • Place of Presentation: Miami, USA