The role of autophagy in tumor-stromal cell interaction
| Project/Area Number |
24659615
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Digestive surgery
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| Research Institution | Kyushu University |
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Principal Investigator |
NAKATA Kohei 九州大学, 大学病院, 助教 (30419569)
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| Co-Investigator(Kenkyū-buntansha) |
SHIRAHANA Kengo 九州大学, 医学研究院, 共同研究員 (10529803)
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 膵臓癌 / オートファジー / 癌間質相互作用 / 膵星細胞 / 癌 |
|---|
| Research Abstract |
We established pancreatic stellate cells from pancreatic cancer tissue obtained during surgery. We identified the autophagy levels in each pancreatic stellate cells and found the levels were different in each cells. We also found the invasiveness of pancreatic cancer cell lines were increased with co-culture with pancreatic stellate cells and identified that its invasiveness was decreased with 3MA.
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Report
(3 results)
Research Products
(7 results)
