Developing microRNA research in cardiac failure
Project/Area Number |
24659632
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Research Category |
Grant-in-Aid for Challenging Exploratory Research
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Allocation Type | Single-year Grants |
Research Field |
Thoracic surgery
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Research Institution | Osaka University |
Principal Investigator |
SAWA Yoshiki 大阪大学, 医学(系)研究科(研究院), 教授 (00243220)
|
Co-Investigator(Kenkyū-buntansha) |
MIYAGAWA Shigeru 大阪大学, 大学院医学系研究科, 講師 (70544237)
YOSHIKAWA Yasushi 大阪大学, 大学院医学系研究科, 助教 (40570594)
FUKUSHIMA Satsuki 大阪大学, 大学院医学系研究科, 助教 (80596867)
NISHI Hiroyuki 大阪大学, 大学院医学系研究科, 助教 (00529208)
|
Project Period (FY) |
2012-04-01 – 2014-03-31
|
Project Status |
Completed (Fiscal Year 2013)
|
Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
|
Keywords | 重症心不全 / 心房細動 / microRNA / 再生医学 / 核酸 |
Research Abstract |
Little is known about microRNA expression in the cardiac tissue of chronic cardiac pathologies. In this study, we investigated relationship between microRNA expression and cardiac pathology in the left ventricular tissue of end-stage cardiac failure patients who completed "bridge to transplantation" using mechanical circulatory support and in the right atrial tissue of chronic atrial fibrillation. As a result, mechanical circulatory supported induced cardiac functional recovery, increase of microvacular number and expression of miR-21 and miR-29b. Furthermore, miR-21 was highly expressed in the atrial tissue of atrial fibrillation, compared to that of sinus rhythm and this was significantly correlated with the degree of fibrosis in the atrial tissue. These results possibly indicated important role of microRNA expression in the cardiac tissue in the progression of the pathology.
|
Report
(3 results)
Research Products
(14 results)
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[Journal Article] Initial experience in Japan with HeartWare ventricular assist system.2014
Author(s)
Nishi H, Toda K, Miyagawa S, Yoshikawa Y, Fukushima S, Saito S, Yoshioka D, Saito T, Ueno T, Sakaguchi T, Sawa Y.
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Journal Title
J Artif Organs
Volume: e-published
Issue: 2
Pages: 149-156
DOI
Related Report
Peer Reviewed
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[Journal Article] DuraHeart<sup>TM</sup> Magnetically Levitated Left Ventricular Assist Device2013
Author(s)
Sakaguchi T, Matsumiya G, Yoshioka D, Miyagawa S, Nishi H, Yoshikawa Y, Fukushima S, Saito S, Ueno T, Sawa Y.
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Journal Title
Circulation Journal
Volume: 77
Issue: 7
Pages: 1736-1741
DOI
NAID
ISSN
1346-9843, 1347-4820
Related Report
Peer Reviewed
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[Journal Article] A slow-releasing form of prostacyclin agonist (ONO1301SR) enhances endogenous secretion of multiple cardiotherapeutic cytokines and improves cardiac function in a rapid-pacing-induced model of canine heart failure.2013
Author(s)
Shirasaka T, Miyagawa S, Fukushima S, Saito A, Shiozaki M, Kawaguchi N, Matsuura N, Nakatani S, Sakai Y, Daimon T, Okita Y, Sawa Y.
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Journal Title
J Thorac Cardiovasc Surg.
Volume: 146
Issue: 2
Pages: 413-21
DOI
Related Report
Peer Reviewed
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[Journal Article] Initial report of bridge to recovery in a patient with DuraHeart LVAD2013
Author(s)
Yoshioka D, Toda K, Sakaguchi T, Miyagawa S, Nishi H, Yoshikawa Y, Fukushima S, Saito S, Saito T, Shibasaki I, Sakata Y, Ohtani T, Sawa Y
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Journal Title
J Artif Organs
Volume: March-2013
Issue: 3
Pages: 1-3
DOI
Related Report
Peer Reviewed
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[Journal Article] Predictor of Early Mortality for Severe Heart Failure Patients With Left Ventricular Assist Device Implantation2012
Author(s)
Yoshioka D, Sakaguchi T, Saito S, Miyagawa S, Nishi H, Yoshikawa Y, Fukushima S, Saito T, Daimon T, Ueno T, Kuratani T, Sawa Y.
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Journal Title
Circulation Journal
Volume: 76
Issue: 7
Pages: 1631-1638
DOI
NAID
ISSN
1346-9843, 1347-4820
Related Report
Peer Reviewed
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