| Project/Area Number |
24659635
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Thoracic surgery
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| Research Institution | Kochi University |
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Principal Investigator |
ANAYAMA Takashi 高知大学, 教育研究部医療学系, 講師 (30403893)
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| Co-Investigator(Kenkyū-buntansha) |
OKADA Hironobu 高知大学, 教育研究部医療学系, 助教 (10444770)
MIYAZAKI Ryohei 高知大学, 教育研究部医療学系, 助教 (70566489)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2014: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | photo-thermal therapy / Photothermal therapy / 光温熱癌治療 / レーザー / 光温熱治療 / 光増感物質 / 肺癌 / 気管支インターベンション |
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| Outline of Final Research Achievements |
We hypothesized that the combination of the existence of photo enhancer and low dose laser irradiation can heat the target tumor selectively to kill the cancer. Systemically administrated porphysomes nano-particles accumulate in lung cancer at higher level than that of normal tissue and absorb red light energy to heat the tumor. Locally injected Indocyanine green also absorb the infra-red light energy to heat the tumor. Using lung cancer animal models, we confirmed the cytotoxic effect of the combination therapy of photo-enhancer administration and low power laser irradiation. Reflect on the promising results of the current study, we are preparing for the clinical study in the next step.
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