| Project/Area Number |
24659650
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Cerebral neurosurgery
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| Research Institution | National Center of Neurology and Psychiatry |
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Principal Investigator |
ARITA Hideyuki 独立行政法人国立がん研究センター, 中央病院, がん専門修練医 (60570570)
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| Co-Investigator(Kenkyū-buntansha) |
KINOSHITA Manabu 地方独立行政法人大阪府立病院機構大阪府立成人病センター(研究所), 脳神経外科, 医長 (40448064)
YOSHIOKA Yoshichika 大阪大学, 免疫学フロンティア研究センター, 特任教授 (00174897)
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | glioma / IDH1 / グリオーマ |
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| Research Abstract |
This study is aimed to reveal the mechanism of the glioma development involving the mutation of isocitrate dehydrogenase 1 (IDH1). We have reveled that IDH1 mutated gliomas show specific patterns of key genetic abnormalities and that those patterns are apparently different from that of IDH1-wild tumors. These results indicated that specific combination of key genetic changes is necessary in order to establish an experimental model of IDH1 mutated gliomas.
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