A model of the development of IDH1 mutated glioma

• Project/Area Number: 24659650
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Single-year Grants
• Research Field: Cerebral neurosurgery
• Research Institution: National Center of Neurology and Psychiatry
• Principal Investigator: ARITA Hideyuki 独立行政法人国立がん研究センター, 中央病院, がん専門修練医 (60570570)
• Co-Investigator(Kenkyū-buntansha): KINOSHITA Manabu 地方独立行政法人大阪府立病院機構大阪府立成人病センター(研究所), 脳神経外科, 医長 (40448064) ; YOSHIOKA Yoshichika 大阪大学, 免疫学フロンティア研究センター, 特任教授 (00174897)
• Project Period (FY): 2012-04-01 – 2014-03-31
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000); Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2012: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
• Keywords: glioma / IDH1 / グリオーマ

Research Abstract

This study is aimed to reveal the mechanism of the glioma development involving the mutation of isocitrate dehydrogenase 1 (IDH1). We have reveled that IDH1 mutated gliomas show specific patterns of key genetic abnormalities and that those patterns are apparently different from that of IDH1-wild tumors. These results indicated that specific combination of key genetic changes is necessary in order to establish an experimental model of IDH1 mutated gliomas.

Research Products

• [Journal Article] Development of a robust and sensitive pyrosequencing assay for the detection of IDH1/2 mutations in gliomas (2014)
  • Author(s): Arita H, Narita Y, Matsushita Y, Fukushima S, Yoshida A, Takami H, Miyakita Y, Ohno M, Shibui S, Ichimura K
  • Journal Title: Brain Tumor Pathol Volume: (in press)
  • URL: http://link.springer.com/article/10.1007%2Fs10014-014-0186-0
  • Peer Reviewed
• [Journal Article] 2.Different spatial distribution between germinal center B and non-germinal center B primary central nervous system lymphoma revealed by magnetic resonance group analysis. (2014)
  • Author(s): Kinoshita M1, Sasayama T, Narita Y, Yamashita F, Kawaguchi A, Chiba Y, Kagawa N, Tanaka K, Kohmura E, Arita H, Okita Y, Ohno M, Miyakita Y, Shibui S, Hashimoto N, Yoshimine T
  • Journal Title: Neuro Oncol Volume: 16 Issue: 5 Pages: 728-734
  • DOI: 10.1093/neuonc/not319
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Risk factors for early death after surgery in patients with brain metastases: reevaluation of the indications for and role of surgery (2014)
  • Author(s): Arita, H., Narita, Y., Miyakita, Y., Ohno, M., Sumi, M., Shibui, S.
  • Journal Title: J Neurooncol Volume: 116 Issue: 1 Pages: 145-152
  • DOI: 10.1007/s11060-013-1273-5
  • Peer Reviewed
• [Journal Article] Usefulness of a glass-free medical three-dimensional autostereoscopic display in neurosurgery. (2014)
  • Author(s): Narita Y, Tsukagoshi S, Suzuki M, Miyakita Y, Ohno M, Arita H, Saito Y, Kokojima Y, Watanabe N, Moriyama N, Shibui S.
  • Journal Title: Int J Comput Assist Radiol Surg. Volume: in press
  • Peer Reviewed
• [Journal Article] Development of a robust and sensitive pyrosequencing assay for the detection of IDH1/2 mutations in gliomas. (2014)
  • Author(s): Arita H, Narita Y, Matsushita Y, Fukushima S, Yoshida A, Takami H, Miyakita Y, Ohno M, Shibui S, Ichimura K.
  • Journal Title: Brain Tumor Pathol. Volume: in press
  • Peer Reviewed
• [Journal Article] TERT promoter mutations rather than methylation are the main mechanism for TERT upregulation in adult gliomas. (2013)
  • Author(s): Arita H, Narita Y, Takami H, Fukushima S, Matsushita Y, Yoshida A, Miyakita Y, Ohno M, Shibui S, Ichimura K.
  • Journal Title: Acta Neuropathol. Volume: 126 Issue: 6 Pages: 939-941
  • DOI: 10.1007/s00401-013-1203-9
  • Peer Reviewed
• [Journal Article] Upregulating mutations in the TERT promoter commonly occur in adult malignant gliomas and are strongly associated with total 1p19q loss. (2013)
  • Author(s): Arita H, Narita Y, Fukushima S, Tateishi K, Matsushita Y, Yoshida A, Miyakita Y, Ohno M, Collins VP, Kawahara N, Shibui S, Ichimura K.
  • Journal Title: Acta Neuropathol. Volume: 126 Issue: 2 Pages: 267-276
  • DOI: 10.1007/s00401-013-1141-6
  • Peer Reviewed
• [Journal Article] Management of glioblastoma in an nf1 patient with moyamoya syndrome : A case report (2013)
  • Author(s): Arita H, Narita Y, Ohno M, Miyakita Y, Okita Y, Ide T, Shibui S
  • Journal Title: Childs Nerv Syst Volume: 29 Issue: 2 Pages: 341-345
  • DOI: 10.1007/s00381-012-1948-9
  • Peer Reviewed
• [Journal Article] Short communication: sclerosing meningioma in the deep sylvian fissure. (2013)
  • Author(s): Fukushima S, Narita Y, Yonezawa M, Ohno M, Arita H, Miyakita Y, Ichimura K, Yoshida A, Shibui S.
  • Journal Title: Brain Tumor Pathol. Volume: in press
  • Peer Reviewed
• [Presentation] Mutations in the TERT promoter are highly recurrent and upregulate TERT expression in gliomas (2013)
  • Author(s): 有田英之
  • Organizer: 第31回日本脳腫瘍学会学術集会
  • Place of Presentation: 宮崎
  • Year and Date: 2013-12-10
• [Presentation] 中枢神経系悪性リンパ腫のサブタイプによる発生部位の相違について~MRIグルーフ解析法による連続100例の解析結果~ (2013)
  • Author(s): 木下学、篠山隆司、成田善孝、山下典生、川口淳、千葉泰良、香川尚己、田中一寛、甲村英二、有田英之、沖田典子、大野誠、宮北康二、澁井壮一郎、橋本直哉、吉峰俊樹
  • Organizer: 第31回日本脳腫瘍学会
  • Place of Presentation: 宮崎
  • Year and Date: 2013-12-08
• [Presentation] Mutations in the TERT promoter are highly recurrent and upregulate TERT expression in gliomas (2013)
  • Author(s): Hideyuki Arita, Yoshitaka Narita, Shintaro Fukushima, Kensuke Tateishi, Yuko Matsushita, Akihiko Yoshida, Yasuji Miyakita, Makoto Ohno, V. Peter Collins, Nobutaka Kawahara, Soichiro Shibui, Koichi Ichimura
  • Organizer: 4th Quadrennial Meeting of the World Federation of Neuro-Oncology
  • Place of Presentation: サンフランシスコ(米国)
  • Year and Date: 2013-11-23
• [Presentation] Different spatial distribution between GCB and non-GCB PCNSL revealed by MR group analysis of 100 cases (2013)
  • Author(s): Kinoshita M, Sasayama T, Narita Y, Kwaguchi A, Yamashita F, Chiba Y, Kagawa N, Tanaka K, Kohmura E, Arita H, Okita Y, Ohon M, Miyakita Y, Shizui S, Hashimoto N, Yoshimine T
  • Organizer: 4th Quadrennial Meeting of the World Federation of Neuro-Oncology
  • Place of Presentation: サンフランシスコ(米国)
  • Year and Date: 2013-11-23
• [Presentation] 転移性脳腫瘍に対する手術の適応と役割 (2013)
  • Author(s): 有田英之、成田善孝、宮北康二、大野誠、米澤元樹、角美奈子、渋井壮一郎
  • Organizer: 第51回日本癌治療学会学術集会
  • Place of Presentation: 京都
  • Year and Date: 2013-10-26
• [Presentation] TERTプロモーター領域の変異はグリオーマに高頻度に認められTERT発現の上昇をもたらす (2013)
  • Author(s): 有田英之、成田善孝、福島慎太郎、立石健祐、松下裕子、吉田朗彦、宮北康二、大野誠、中村大志、川原信隆、渋井壮一郎、市村幸一
  • Organizer: 第72回日本脳神経外科学会学術集会
  • Place of Presentation: 横浜
  • Year and Date: 2013-10-17
• [Presentation] マルチモダール画像/組織ライブラリー構築のためのナビゲーション解析ソフトウエアの開発～マルチモダール手術の検証を目指して～ (2013)
  • Author(s): 木下学、高野浩司、沖田典子、千葉泰良、香川尚己、橋本直哉、吉峰俊樹
  • Organizer: 第72回日本脳神経外科学会総会
  • Place of Presentation: 横浜
  • Year and Date: 2013-10-16
• [Presentation] 悪性脳腫瘍手術におけるマルチモダール手術支援技術の検証 (2013)
  • Author(s): 木下学、有田英之、沖田典子、千葉泰良、香川尚己、畑澤順、橋本直哉、吉峰俊
  • Organizer: 第18回日本脳腫瘍の外科学会
  • Place of Presentation: 大津
  • Year and Date: 2013-09-19
• [Presentation] Pyrosequence法を用いたグリオーマにおけるIDH 1/ 2遺伝子変異の判定法 (2013)
  • Author(s): 有田英之、成田善孝、松下裕子、吉田朗彦、宮北康二、大野誠、渋井壮一郎、市村幸一
  • Organizer: 第31回日本脳腫瘍病理学会
  • Place of Presentation: 東京
  • Year and Date: 2013-05-25
• [Presentation] Pyrosequence 法を用いたグリオーマにおけるIDH1/2遺伝子変異の判定法 (2013)
  • Author(s): 有田英之、成田善孝、松下裕子、福島慎太郎、宮北康二、大野誠、吉田朗彦、渋井壮一郎、市村幸一
  • Organizer: 第３１回日本脳腫瘍病理学会
  • Place of Presentation: 東京
• [Presentation] 先端巨大症におけるTRH試験反応性と腫瘍の特性に関する検討 (2013)
  • Author(s): 有田英之、木下学、押野悟、後藤雄子、北村哲宏、大月道夫、吉峰俊樹、齋藤洋一
  • Organizer: 第23回間脳下垂体腫瘍学会
  • Place of Presentation: 鹿児島
• [Presentation] 転移性脳腫瘍の手術適応の再検討~早期死亡例の解析から (2012)
  • Author(s): 有田英之、成田善孝、宮北康二、大野誠、野村昌志、渋井壮一郎
  • Organizer: 第30回日本脳腫瘍学会学術集会
  • Place of Presentation: 広島
  • Year and Date: 2012-11-25
• [Presentation] DIFFERENTIATION BETWEEN HIGH- AND LOW-GRADE MR NON-ENHANCING GLIOMAS USING PET; COMPARISON OF 11C-METHIONINE, FDG PET, AND 11C- METHIONINE/FDG DECOUPLING SCORE (2012)
  • Author(s): Kinoshita M, Arita H, Chiba Y, Kagawa N, Nonaka M, Kanemura Y, Kishima H, Nakajima S, Hatazawa J, Hashimoto N, Yoshimine T
  • Organizer: The 17th Annual Scientific Meeting of the Society for Neuro- Oncology
  • Place of Presentation: ワシントン(米国)
  • Year and Date: 2012-11-17
• [Presentation] FDG/11C-methionine PET非同期度による非造影グリオーマのグレード判別 (2012)
  • Author(s): 木下学、平山龍一、千葉泰良、香川尚己、埜中正博、金村米博、貴島晴彦、中島伸、畑澤順、橋本直哉、吉峰俊樹
  • Organizer: 第71回日本脳神経外科学会学術総会
  • Place of Presentation: 大阪
  • Year and Date: 2012-10-19
• [Presentation] 転移性脳腫瘍の手術適応の再検討?早期死亡例の解析から? (2012)
  • Author(s): 有田英之、成田善孝、宮北康二、大野誠、野村昌志、渋井壮一郎
  • Organizer: 日本脳神経外科学会第71回学術総会
  • Place of Presentation: 大阪
  • Year and Date: 2012-10-18
• [Presentation] 髄膜腫における PET の臨床的意義の検討: 増大速度・病理所見との比較 (2012)
  • Author(s): 有田英之、木下学、沖田典子、平山龍一、木嶋教行、香川尚己、森井英一、橋本直哉、吉峰俊樹
  • Organizer: 第３０回日本脳腫瘍病理学会
  • Place of Presentation: 名古屋
• [Presentation] 転移性脳腫瘍の手術適応の再検討~早期死亡例の解析から~ (2012)
  • Author(s): 有田英之、成田善孝、宮北康二、大野誠、渋井壮一郎
  • Organizer: 日本脳神経外科学会第71回学術総会
  • Place of Presentation: 大阪
• [Presentation] 悪性脳腫瘍手術におけるマルチモダール手術支援技術の検証
  • Author(s): 木下学、有田英之、沖田典子、千葉泰良、香川尚己、畑澤順、橋本直哉、吉峰俊樹
  • Organizer: 第18回日本脳腫瘍の外科学会
  • Place of Presentation: 大津
• [Presentation] 転移性脳腫瘍に対する手術の適応と役割
  • Author(s): 有田英之、成田善孝 、宮北康二 、大野誠 、米澤元樹、角美奈子、渋井壮一郎
  • Organizer: 第51回日本癌治療学会学術集会
  • Place of Presentation: 京都
• [Presentation] Mutations in the TERT promoter are highly recurrent and upregulate TERT expression in gliomas.
  • Author(s): 有田英之
  • Organizer: 第31回日本脳腫瘍学会学術集会
  • Place of Presentation: 宮崎
• [Presentation] Mutations in the TERT promoter are highly recurrent and upregulate TERT expression in gliomas
  • Author(s): Hideyuki Arita, Yoshitaka Narita, Shintaro Fukushima, Kensuke Tateishi, Yuko Matsushita, Akihiko Yoshida, Yasuji Miyakita, Makoto Ohno, V. Peter Collins, Nobutaka Kawahara, Soichiro Shibui, Koichi Ichimura
  • Organizer: 4th Quadrennial Meeting of the World Federation of Neuro-Oncology
  • Place of Presentation: サンフランシスコ（米国）
• [Presentation] 中枢神経系悪性リンパ腫のサブタイプによる発生部位の相違について ~MRIグルーフ解析法による連続100例の解析結果~
  • Author(s): 木下学、篠山隆司、成田善孝、山下典生、川口淳、千葉泰良、香川尚己、田中一寛、甲村英二、有田英之、沖田典子、大野誠、宮北康二、澁井壮一郎、橋本直哉、吉峰俊樹
  • Organizer: 第31回日本脳腫瘍学会学術集会
  • Place of Presentation: 宮崎
• [Presentation] Different spatial distribution between GCB and non-GCB PCNSL revealed by MR group analysis of 100 cases.
  • Author(s): Kinoshita M, Sasayama T, Narita Y, Kwaguchi A, Yamashita F, Chiba Y, Kagawa N, Tanaka K, Kohmura E, Arita H, Okita Y, Ohon M, Miyakita Y, Shizui S, Hashimoto N, Yoshimine T.
  • Organizer: 4th Quadrennial Meeting of the World Federation of Neuro-Oncology
  • Place of Presentation: サンフランシスコ（米国）
• [Presentation] マルチモダール画像／組織ライブラリー構築のためのナビゲーション解析ソフトウエアの開発～マルチモダール手術の検証を目指して～
  • Author(s): 木下学、高野浩司、沖田典子、千葉泰良、香川尚己、橋本直哉、吉峰俊樹
  • Organizer: 第72回日本脳神経外科学会総会
  • Place of Presentation: 横浜
• [Presentation] 11C-methionine PET parametric response map, but not conventional MRI, corresponds to treatment response of WT1 immunotherapy for recurrent malignant glioma.
  • Author(s): Kinoshita M, Arita H, Chiba Y, Kagawa N, Nonaka M, Kanemura Y, Kishima H, Nakajima S, Hatazawa J, Hashimoto N, Yoshimine T
  • Organizer: International Society for Magnetic Resonance in Medicine (ISMRM) 20th Scientific Meeting.
  • Place of Presentation: Melbourne, Australia
• [Presentation] マルチモダリティナビゲーションガイド下定位的組織採取のための解析ソフトウェア開発
  • Author(s): 木下学、平山龍一、千葉泰良、香川直己、橋本直哉、吉峰俊樹
  • Organizer: 第64回日本脳神経外科学会近畿支部学術集会
  • Place of Presentation: 大阪
• [Presentation] DIFFERENTIATION BETWEEN HIGH- AND LOW-GRADE MR NON-ENHANCING GLIOMAS USING PET–COMPARISON OF 11C-METHIONINE, FDG PET, AND 11C-METHIONINE/FDG DECOUPLING SCORE
  • Author(s): Kinoshita M, Arita H, Chiba Y, Kagawa N, Nonaka M, Kanemura Y, Kishima H, Nakajima S, Hatazawa J, Hashimoto N, Yoshimine T
  • Organizer: The 17th Annual Scientific Meeting of the Society for Neuro-Oncology
  • Place of Presentation: Washington DC, USA
• [Presentation] Affibody-SPIO によるMR 分子イメージング
  • Author(s): 木下学、吉岡義親、沖田典子、有田英之、平山龍一、千葉泰良、橋本直哉、吉峰俊樹
  • Organizer: 第30回日本脳腫瘍学会学術集会
  • Place of Presentation: 広島
• [Presentation] 4D造影CTによる機能性微小下垂体腺腫の局在診断と造影効果の動態解析
  • Author(s): 木下 学、有田英之、田中 壽、後藤雄子、押野 悟、渡邉嘉之、齋藤洋一
  • Organizer: 第23回間脳下垂体腫瘍学会
  • Place of Presentation: 鹿児島