Cell-based Cytokine Delivery strategy for chroniccerebral infarction

• Project/Area Number: 24659660
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Cerebral neurosurgery
• Research Institution: 公益財団法人先端医療振興財団
• Principal Investigator: MATSUYAMA Akifumi 公益財団法人先端医療振興財団, 再生医療開発支援部, 部長 (10423170)
• Co-Investigator(Kenkyū-buntansha): TAGUCHI Akihiko (公財)先端医療振興財団, 再生医療研究部, 部長 (10359276)
• Project Period (FY): 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000); Fiscal Year 2012: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
• Keywords: 再生医学 / 脳血管障害学

Research Abstract

INTRODUCTION: Stem cell therapy can promote good recovery from stroke. Several studies have demonstrated that adipose tissue-derived cells are safe and effective. However, more infbrmation regarding appropriate cell type is needed from animal model. This stUdy was targeted at analyzing the effects in ischemic stroke ofintravenous(i.v.)administration ofadipose tissue-derived multi-lineage progenitor cells(ADMPCs)and adipose-derived-stem cells(ADSCs)on fUnctional evaluation results. METHODS:ADMPCs or ADSCswere administered intravenously 30 minutes after permanent middle cerebral artery occlusion(pMCAO)to rats. Infarct volume was analyzed by histologically. Function was evaluated by the Rogers and rotarod tests. RESULTS:Compared to infarct group, fUnction had significantly improved after i.v. administration of ADMPCs but not ADSCs. Reduction in infarct volume was observed in the ADMPC-transplanted group nut not in the ADSC-one. CONCLUSIONS: i.v. administration ofADMPCs but not AD SCs, in pMCAO infarct was associated with good fUnctional recovery, and reductions in infarct volume.

Research Products

• [Journal Article] Adipose Tissue-Derived Multi-lineage Progenitor Cells as a Prom ising Tool for 1カSitu Stem Cell Therapy (2012)
  • Author(s): Okura H, Saga A, Soeda M. Ichinose A, Matsuyama A
  • Journal Title: Current Tissue Engineering Volume: (In press)
  • Peer Reviewed
• [Journal Article] Tissue engineered myoblast sheets improved cardiac function sufHciently to discontinue LVAS in a patient with DCM: report of a case (2012)
  • Author(s): Sawa Y, Miyagawa S, Sakaguchi T, Fuj ita T, .Matsuyama A, Saito A, Shimizu T, Okano T
  • Journal Title: Surg Today Volume: 42 Pages: 181-184
  • Peer Reviewed
• [Journal Article] Patients with CD36 Deficiency Are Associated with Enhanced Atherosclerotic Cardiovascular Diseases (2011)
  • Author(s): Yuasa-Kawase M, Masuda D, Yamashita T, Kawase R, Nakaoka H, Inagaki M, Nakatani K, Tsubakio-Yamamoto K, Ohama T, .Matsuyama A, Nishida M, Ishigami M, Kawamoto T, Komuro I, Yamashita S
  • Journal Title: J Atheroscler Thromb Volume: 19 Pages: 263-275
  • NAID: 130004444587
  • Peer Reviewed
• [Journal Article] Fasting Serum Apolipoprotein B-48 Can be a Marker of Postprandial Hyperlipidemia (2011)
  • Author(s): Masuda D, Sakai N, Sugimoto T, Kitazume-Taneike R, Yamashita T, Kawase R,Nakaoka H, Inagaki M, Nakatani K, Yuasa-Kawase M, Tsubakio-Yamamoto K, Ohama T, Nakagawa-Toyama Y, Nishida M, Ishigami M, Masuda Y, Matsuyama A, Komuro I, Yamashita S
  • Journal Title: J Atheroscler Thromb Volume: 18 Pages: 1062-1070
  • NAID: 130004845356
  • Peer Reviewed
• [Journal Article] Reduction of Neu5GC Xenoantigen on Human ADMSCs lead to Them as Safer and More Useful Cell Sources fbr Realizing Various Stem Cell Therapies (2010)
  • Author(s): Komoda H, Okura H, LeeC-M, Sougawa N, Iwayama T, Hashikawa T, Saga A, Yamamoto-Kakuta A, Ichino se A, Murakami S, Sawa Y and Matsuyama A
  • Journal Title: Tissue Eng Part A Volume: 16(4) Pages: 1143-1155
  • Peer Reviewed
• [Journal Article] HDL/apolipoprotein A-I binds to macrophage-derived progranulin and suppresses its conversion into proinflammatory granulins (2010)
  • Author(s): Okura H, Yamashita S, Tohru Ohama, Saga A,Kakuta-Yamamoto A, Hamada Y, Ohyama R, Sawa Y and Matsuyama A
  • Journal Title: J Atheroscler Thromb Volume: 17(6) Pages: 568-577
  • NAID: 130004845317
  • Peer Reviewed
• [Journal Article] Cardiomyoblast-like cells differentiated from human adipose tissue-derived mesenchymal stem cells improve left ventricular dysfUnction and survival in a rat myocardial infarction model (2010)
  • Author(s): Okura H, Matsuvama A. Lee CM, Saga A, Kakuta-Yamamoto A, Nagao A, Sougawa N,Sekiya N, Takekita K, Shudo Y, Miyagawa S, Komoda H, Okano T, Sawa Y
  • Journal Title: Tissue Eng Part C Methods Volume: 16(3) Pages: 417-425
  • Peer Reviewed
• [Patent(Industrial Property Rights)] 心筋指向性細胞を含む細胞製剤 (2012)
  • Inventor(s): 松山晃文、大倉華雪
  • Industrial Property Rights Holder: 理化学研究所、大阪大学、(公財)先端医療振興財団
  • Industrial Property Number: 2012-100362
  • Filing Date: 2012-04-25