| Project/Area Number |
24659705
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Anesthesiology/Resuscitation studies
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| Research Institution | Keio University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
MINAMISHIMA Shiszuka 慶應義塾大学, 医学部, 講師 (20593966)
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| Co-Investigator(Renkei-kenkyūsha) |
AKIKO Kubo 慶應義塾大学, 医学部, 特任講師 (50455573)
TAKAKO Hishiki 慶應義塾大学, 医学部, 講師 (10338022)
MAKOTO Suematsu 慶應義塾大学, 医学部, 教授 (00206385)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2014: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2013: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2012: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 低酸素応答 / 心停止 / 心肺蘇生 / 虚血再灌流障害 |
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| Outline of Final Research Achievements |
We demonstrated that inhaled Nitric oxide (NO) could improve outcome after successful cardiopulmonary resuscitation (CPR) in mice. It is increasingly recognized that NO production in hypoxia correlate with HIF (hypoxia inducible factor), a transcription factor which regulate hypoxic response. The present study tried to demonstrate whether systemically activating HIF in mice could improve the outcome after CPR.
Although survival rate, neurological and cardiac function ware assessed after cardiac arrest and CPR, HIF activation did not work to improve outcome after CPR.
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