Hypoxic response as a new treatment of Post cardiac arrest syndrome

• Project/Area Number: 24659705
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Anesthesiology/Resuscitation studies
• Research Institution: Keio University
• Principal Investigator: MINAMISHIMA Shizuka 慶應義塾大学, 医学部, 助教 (20622088)
• Co-Investigator(Kenkyū-buntansha): MINAMISHIMA Shiszuka 慶應義塾大学, 医学部, 講師 (20593966)
• Co-Investigator(Renkei-kenkyūsha): AKIKO Kubo 慶應義塾大学, 医学部, 特任講師 (50455573) ; TAKAKO Hishiki 慶應義塾大学, 医学部, 講師 (10338022) ; MAKOTO Suematsu 慶應義塾大学, 医学部, 教授 (00206385)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000); Fiscal Year 2014: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000); Fiscal Year 2013: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000); Fiscal Year 2012: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
• Keywords: 低酸素応答 / 心停止 / 心肺蘇生 / 虚血再灌流障害

Outline of Final Research Achievements

We demonstrated that inhaled Nitric oxide (NO) could improve outcome after successful cardiopulmonary resuscitation (CPR) in mice. It is increasingly recognized that NO production in hypoxia correlate with HIF (hypoxia inducible factor), a transcription factor which regulate hypoxic response. The present study tried to demonstrate whether systemically activating HIF in mice could improve the outcome after CPR.
Although survival rate, neurological and cardiac function ware assessed after cardiac arrest and CPR, HIF activation did not work to improve outcome after CPR.

Research Products

• [Journal Article] The Effect of Epidural Anesthesia on Growth of Escherichia Coli at Pseudosurgical site: The Roles of the Lipocalin-2 Pathway. (2015)
  • Author(s): Igarashi T, Suzuki T, Mori K, Inoue K, Seki H,Yamada T, Kosugi S, Minamishima S, Katori N, Sano F, Abe T, Morisaki H
  • Journal Title: Anesthesia & Analgesia Volume: 120
  • Peer Reviewed / Open Access
• [Journal Article] 一酸化窒素(NO)吸入療法 (2014)
  • Author(s): 南嶋しづか、森崎 浩、武田純三
  • Journal Title: Mebio Volume: 31(2) Pages: 74-79
• [Journal Article] 救急・緊急時に使用する薬剤 (2013)
  • Author(s): 南嶋しづか
  • Journal Title: OPE NURSING Volume: 28(3) Pages: 299-310
• [Journal Article] Sodium sulfide prevents water diffusion abnormality in the brain and improves long term outcome after cardiac arrest in mice. (2012)
  • Author(s): Kida K, Minamishima S, Wang H, Ren J, Yigitkanli K, Nozari A, Mandeville JB, Liu PK, Liu CH, Ichinose F.
  • Journal Title: Resuscitation Volume: 83(10) Issue: 10 Pages: 1292-1297
  • DOI: 10.1016/j.resuscitation.2012.02.020
  • Peer Reviewed
• [Presentation] 内毒素血症ラットモデルにおいて深麻酔中のノルエピネフリンによる昇圧は予後を悪化させる (2015)
  • Author(s): 井上 敬、五十嵐 達、鈴木武志、南嶋しづか、関 博志、森﨑 浩
  • Organizer: 日本麻酔科学会第62回学術集会
  • Place of Presentation: 神戸ポートピアホテル（兵庫県神戸市）
  • Year and Date: 2015-05-28 – 2015-05-30
• [Presentation] ラット侵襲モデルにおいて深い吸入麻酔は炎症性サイトカイン分泌を促進する (2014)
  • Author(s): 井上 敬、五十嵐 達、鈴木武志、南嶋しづか、森﨑 浩
  • Organizer: 日本麻酔科学会第61回学術集会
  • Place of Presentation: パシフィコ横浜（神奈川県横浜市）
  • Year and Date: 2014-05-15 – 2014-05-17
• [Presentation] 吸入一酸化窒素は心停止・心肺蘇生後マウスの予後を改善する (2012)
  • Author(s): 南嶋しづか、木田康太郎、徳田賢太郎、小杉志津子、武田純三、市瀬 史
  • Organizer: 日本麻酔科学会 第５９回学術集会
  • Place of Presentation: 兵庫県神戸市 神戸ポートピアホテル