| Project/Area Number |
24659716
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Urology
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| Research Institution | Nagoya City University |
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Principal Investigator |
KENJIRO Kohri 名古屋市立大学, その他部局等, 学長 (30122047)
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| Co-Investigator(Kenkyū-buntansha) |
TOZAWA Keiichi 名古屋市立大学, 大学院医学研究科, 准教授 (40264733)
YASUI Takahiro 名古屋市立大学, 大学院医学研究科, 教授 (40326153)
OKADA Atsushi 名古屋市立大学, 大学院医学研究科, 講師 (70444966)
HAMAMOTO Shuzo 名古屋市立大学, 大学院医学研究科, 助教 (80551267)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2014: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2013: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2012: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | 尿路結石 / オステオポンチン / ミトコンドリア / マクロファージ |
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| Outline of Final Research Achievements |
(1) Thrombin-cleaved osteopontin plays an important role in formation of renal calcium crystals and that 35B6-Ab contributes to the remarkable inhibition of early-stage renal crystal formation by preventing renal tubular cell injury and crystal-cell attachment. (2) To experimentally evaluate the clinical application of N-methyl-4-isoleucine cyclosporin, a novel selective inhibitor of cyclophilin D activation.We first report a new treatment agent determining renal calcium crystallization through cyclophilin D activation. (3)M2Mφ transfusion directly suppressed crystal formation and the marked crystal phagocytic ability of M2Mφs.
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