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2014 Fiscal Year Final Research Report

Biomolecular mechanism of urinary stone formation, and development of medicine

Research Project

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Project/Area Number 24659716
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Urology
Research InstitutionNagoya City University

Principal Investigator

KENJIRO Kohri  名古屋市立大学, その他部局等, 学長 (30122047)

Co-Investigator(Kenkyū-buntansha) TOZAWA Keiichi  名古屋市立大学, 大学院医学研究科, 准教授 (40264733)
YASUI Takahiro  名古屋市立大学, 大学院医学研究科, 教授 (40326153)
OKADA Atsushi  名古屋市立大学, 大学院医学研究科, 講師 (70444966)
HAMAMOTO Shuzo  名古屋市立大学, 大学院医学研究科, 助教 (80551267)
Project Period (FY) 2012-04-01 – 2015-03-31
Keywords尿路結石 / オステオポンチン / ミトコンドリア / マクロファージ
Outline of Final Research Achievements

(1) Thrombin-cleaved osteopontin plays an important role in formation of renal calcium crystals and that 35B6-Ab contributes to the remarkable inhibition of early-stage renal crystal formation by preventing renal tubular cell injury and crystal-cell attachment. (2) To experimentally evaluate the clinical application of N-methyl-4-isoleucine cyclosporin, a novel selective inhibitor of cyclophilin D activation.We first report a new treatment agent determining renal calcium crystallization through cyclophilin D activation. (3)M2Mφ transfusion directly suppressed crystal formation and the marked crystal phagocytic ability of M2Mφs.

Free Research Field

泌尿器科学

URL: 

Published: 2016-06-03  

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