• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Basic science and cerebral palsy clinical research of human umbilical cord blood stem cells

Research Project

Project/Area Number 24659733
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Obstetrics and gynecology
Research InstitutionKochi University

Principal Investigator

MAEDA Nagamasa  高知大学, 教育研究部医療学系, 教授 (60229309)

Co-Investigator(Kenkyū-buntansha) SHEN Yuan  高知大学, 教育研究部医療学系, 講師 (50294830)
TSURU Emi  高知大学, 教育研究部医療学系, 助教 (70380318)
Project Period (FY) 2012-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2014: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Keywords臍帯血 / 幹細胞 / 小児脳性麻痺 / 細胞輸血治療 / 脳性麻痺
Outline of Final Research Achievements

To reveal the therapeutic effects of human umbilical cord blood stem cell transplantation on cerebral palsy, we identify stem cell populations in umbilical cord blood, and analyze the frequencies and percentages of the stem cell populations.
We showed that unique stem cell populations expressed the stem cell markers, such as Oct3/4, Nanog, Sox2, Tra-1-60 and SSEA4. In addition, we demonstrated that stem cell marker genes were up-regulated and not only hematopoietic stem cells but also the unique stem cell populations were significantly increased under the culture for maintenance of undifferentiated state.

Report

(4 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • 2012 Research-status Report
  • Research Products

    (10 results)

All 2015 2014 2013 2012 Other

All Journal Article (2 results) (of which Peer Reviewed: 2 results,  Open Access: 1 results) Presentation (7 results) Remarks (1 results)

  • [Journal Article] Syngeneic transplantation of newborn splenocytes in a murine model of neonatal ischemia-reperfusion brain injury.2014

    • Author(s)
      Wang F, Shen Y, Tsuru E, Yamashita T, Baba N, Tsuda M, Maeda N, Sagara Y.
    • Journal Title

      J Matern Fetal Neonatal Med.

      Volume: 17 Issue: 7 Pages: 1-6

    • DOI

      10.3109/14767058.2014.935327

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] The therapeutic potential of human umbilical cord blood transplantation for neonatal hypoxic-ischemic brain injury and ischemic stroke.2012

    • Author(s)
      Wang F, Maeda N, Yasuhara T, Kameda M, Tsuru E, Yamashita T, Shen Y, Tsuda M, Date I, Sagara Y.
    • Journal Title

      Acta Medica Okayama

      Volume: 66 Pages: 429-34

    • NAID

      120004873435

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Presentation] 新生仔脳虚血再灌流障害モデルマウスの臍帯血移植療法における内在性神経幹細胞の損傷脳再生機構2015

    • Author(s)
      王 飛霏、沈 淵、山下竜幸、馬場伸育、都留英美、津田雅之、前田長正、    相良祐輔
    • Organizer
      第14回日本再生医療学会総会
    • Place of Presentation
      神奈川(パシフィコ横浜)
    • Year and Date
      2015-03-19 – 2015-03-21
    • Related Report
      2014 Annual Research Report
  • [Presentation] ヒト臍帯血細胞と骨髄細胞の幹細胞マーカー発現についての比較検討2015

    • Author(s)
      飯塚 美知郎、都留 英美、馬場 伸育、王 飛霏、津田 雅之、常風 興平、横田 淳子、前田 長正、宮村 充彦、相良 祐輔
    • Organizer
      第14回日本再生医療学会総会
    • Place of Presentation
      神奈川(パシフィコ横浜)
    • Year and Date
      2015-03-19 – 2015-03-21
    • Related Report
      2014 Annual Research Report
  • [Presentation] 新生仔脳虚血再灌流障害モデルマウスの確立と同種同系脾細胞移植の試み2014

    • Author(s)
      王飛霏, 沈淵, 山下竜幸, 馬場伸育, 都留英美, 津田雅之, 前田長正, 相良祐輔
    • Organizer
      第2回臍帯血による再生医療研究会
    • Place of Presentation
      東京(山王病院3階メインホール)
    • Year and Date
      2014-07-12
    • Related Report
      2014 Annual Research Report
  • [Presentation] 臍帯血幹細胞の未分化性維持培養の試み2014

    • Author(s)
      都留英美, 津田雅之, 馬場伸育, 山下竜幸, 王飛霏, 沈淵, 前田長正, 相良祐輔
    • Organizer
      第2回臍帯血による再生医療研究会
    • Place of Presentation
      東京(山王病院3階メインホール)
    • Year and Date
      2014-07-12
    • Related Report
      2014 Annual Research Report
  • [Presentation] 新生児脳虚血再還流傷害モデルマウスの確立と同種同系臍帯血幹細胞移植の試み2013

    • Author(s)
      王 飛霏、都留英美、山下竜幸、沈淵、高石公子、津田雅之、前田長正、相良祐輔
    • Organizer
      第12回日本再生医療学会総会
    • Place of Presentation
      パシフィコ横浜(神奈川県)
    • Related Report
      2012 Research-status Report
  • [Presentation] ヒト臍帯血幹細胞の同定と出現率2013

    • Author(s)
      都留英美、山下竜幸、王飛霏、沈淵、黒岩裕美、津田雅之、前田長正、相良祐輔
    • Organizer
      第12回日本再生医療学会総会
    • Place of Presentation
      パシフィコ横浜(神奈川県)
    • Related Report
      2012 Research-status Report
  • [Presentation] マウスの脳性麻痺疾患モデルの樹立及び臍帯血幹細胞を用いた治療法開発の試み2012

    • Author(s)
      沈 淵、都留英美、矢生健一、王 飛霏、江端千尋、津田雅之、前田長正
    • Organizer
      第11回日本再生医療学会総会
    • Place of Presentation
      パシフィコ横浜(神奈川県)
    • Related Report
      2012 Research-status Report
  • [Remarks] 高知大学医学部先端医療学推進センター再生医療部門臍帯血幹細胞研究班

    • URL

      http://www.kochi-ms.ac.jp/~cbsct/index.html

    • Related Report
      2013 Research-status Report

URL: 

Published: 2013-05-31   Modified: 2019-07-29  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi