| Project/Area Number |
24659769
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Ophthalmology
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| Research Institution | St. Marianna University School of Medicine |
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Principal Investigator |
UEDA Yuji 聖マリアンナ医科大学, 医学部, 講師 (00223470)
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| Co-Investigator(Renkei-kenkyūsha) |
SUZUKI Noboru 聖マリアンナ医科大学, 医学部, 教授 (40235982)
ARIMITSU Nagisa 聖マリアンナ医科大学, 医学部, 助教 (40408688)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2014: ¥260,000 (Direct Cost: ¥200,000、Indirect Cost: ¥60,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | iPS細胞 / 網膜 / 視細胞 / ロドプシン / 転写因子 / 桿体視細胞 / 錐体視細胞 / 網膜前駆細胞 / 再生医学 / オプシン |
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| Outline of Final Research Achievements |
The retinal tissue is derived from the central nervous system and does not have the regeneration ability. Thus once damaged, regeneration of retina is almost impossible. We generated retinal progenitor cell lines from mouse iPS cells transfected with pax6 cDNA, and by using the cloned retinal progenitors we made retinal cell sheet including rhodopsin positive photoreceptor cells. They made massive synaptic connection among them and the sheet looked resembling naïve retinal neuron layers. It could be clinically applicable for patients with damaged retina.
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