| Project/Area Number |
24659804
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Emergency medicine
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| Research Institution | Osaka Institute of Technology |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
MARUYAMA Ikuro 鹿児島大学, 大学院医歯(薬)学総合研究科, 特任教授 (20082282)
HASHIGUCHI Teruto 鹿児島大学, 大学院医歯(薬)学総合研究科, 教授 (70250917)
ITO Takashi 鹿児島大学, 大学院医歯(薬)学総合研究科, 特任講師 (20381171)
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | ヌクレオフォスミン / アラーミン / 免疫活性化 / ファゴサイトーシス / 救急医学 / 敗血症 |
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| Research Abstract |
Nucleophosmin is a major nucleolar multifunctional protein involved in ribosome biogenesis, centrosome duplication, cell cycle progression, apoptosis, and cell differentiation. Alarmins are endogenous molecules released from activated cells and/or dying cells, which activate the immune system and cause severe damage to cells and tissue organs. Recently, the nucleophosmin is released from endotoxin-stimulated RAW264.7 cells and induces cytokines, suggesting that nucleophosmin might be an alarmin. However, nucleophosmin as a alarmin remains unclear. In this study, we found that the nucleophosmin-stimulated RAW264.7 cells significantly enhanced phagocytosis with flowcytometry. Furthermore, the nuclephosmin enhanced phagocytosis in in a dose-dependent fashion. Our findings suggest that nucleophosmin may be an alarmin.
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