| Project/Area Number |
24659812
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Morphological basic dentistry
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| Research Institution | Osaka University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
TERAO Yutaka 新潟大学, 大学院医歯学総合研究科, 教授 (50397717)
NAKATA Masanobu 大阪大学, 大学院歯学研究科, 准教授 (90444497)
SUMITOMO Tomoko 大阪大学, 大学院歯学研究科, 助教 (50423421)
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 口腔細菌 / シクロデキストリン / 上皮バリア / 口腔常在細菌 |
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| Research Abstract |
Alpha-glucans such as starch and glycogen are abundant in the human oral cavity. Degradation of alpha-glucans by alpha-glucanotransferase (CGTase) enzymes leads to the clodextrins (CDs) production. CDs induce a cholesterol-depleted membrane and a destabilization of the barrier function of tight junctions in host cells. We demonstrated that Porphyromonas gingivalis, a periodontal pathogen, utilizes alpha-glucans to produce CDs. Our data suggest that P. gingivalis-produced CDs contribute to the pathogenesis of oral bacteria-associated systemic illness.
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