| Project/Area Number |
24659813
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Morphological basic dentistry
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| Research Institution | Okayama University |
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Principal Investigator |
YAMAMOTO Toshio 岡山大学, 医歯(薬)学総合研究科, 教授 (30107776)
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| Co-Investigator(Kenkyū-buntansha) |
IKEGAME Mika 岡山大学, 大学院医歯薬学総合研究科, 准教授 (70282986)
KAWAI Mariko 大阪歯科大学, 歯学部, 講師 (40379839)
SUGIYAMA Toshie 新潟大学, 自然科学系, 准教授 (10272858)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2014: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | ウズラ / 骨髄骨 / 卵殻腺 / 破骨細胞 / プロゲステロン / 性ホルモン / 骨吸収 / 鳥類 / 骨形成 / 骨芽細胞 / RANKL |
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| Outline of Final Research Achievements |
To study the synchronizing mechanism among shell gland and medullary bone for the eggshell calcification in Japanese quail, the effects of progesterone and the mechanical tension caused by plumped shell gland itself by an egg over the osteoclastic activity of medullary bone were examined. Progesterone administered at the active stage of medullary bone osteoclasts inhibited the osteoclasts. And the extraction of an egg from shell gland to remove mechanical tension also caused the inhibition of osteoclastic activity in medullary bone. These results strongly suggest that progesterone, and the mechanical tension in shell gland by pumping, respectively may play important roles for the periodic change of the osteoclastic activity synchronized with egg laying cycle in medullary bone.
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