| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Outline of Final Research Achievements |
Cells regulate activation programs through an complex network of molecular interactions. Genome-wide analyses and gene-targeting studies unveiled evidence that inflammatory cytokines influence bone cells via inflammatory transcription factors e.g., nuclear factor (NF)-κB. Stimulation with antigen and IgE activates NF-κB in mast cells. In the present research, we studied the role of NF-κB on cellular migration using the NF-κB inhibitor (–)-DHMEQ. (–)-DHMEQ inhibited antigen/IgE-induced expressions of IL-6 and TNF-α and lowered the expression of matrix metalloproteinase (MMP-2) resulting in the inhibition of invasion toward the antigen. Successful results of the dynamic analyses may reveal a mechanism that underlies the role of inflammation in bone metabolism and have promise as a strategy for exploring drug targets of a variety of bone diseases.
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