Signaling dynamics of inflammatory cellular responses in the activation of pothogenic bone destruction program
Project/Area Number |
24659822
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Research Category |
Grant-in-Aid for Challenging Exploratory Research
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Allocation Type | Multi-year Fund |
Research Field |
Functional basic dentistry
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Research Institution | Kyoto University |
Principal Investigator |
ASAGIRI MASATAKA 京都大学, 医学(系)研究科(研究院), 准教授 (20372435)
|
Project Period (FY) |
2012-04-01 – 2015-03-31
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Project Status |
Completed (Fiscal Year 2014)
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Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
|
Keywords | 関節リウマチ / 免疫学 / 病理学 / 自己免疫 / 炎症 / 転写因子 / 組織破壊 / 骨代謝 / 歯周病 / 細胞変容 / 破骨細胞 / 骨破壊 / 炎症性細胞変容 / システム生物学 / 組織恒常性 |
Outline of Final Research Achievements |
Cells regulate activation programs through an complex network of molecular interactions. Genome-wide analyses and gene-targeting studies unveiled evidence that inflammatory cytokines influence bone cells via inflammatory transcription factors e.g., nuclear factor (NF)-κB. Stimulation with antigen and IgE activates NF-κB in mast cells. In the present research, we studied the role of NF-κB on cellular migration using the NF-κB inhibitor (–)-DHMEQ. (–)-DHMEQ inhibited antigen/IgE-induced expressions of IL-6 and TNF-α and lowered the expression of matrix metalloproteinase (MMP-2) resulting in the inhibition of invasion toward the antigen. Successful results of the dynamic analyses may reveal a mechanism that underlies the role of inflammation in bone metabolism and have promise as a strategy for exploring drug targets of a variety of bone diseases.
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Report
(3 results)
Research Products
(10 results)
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[Journal Article] Migration of splenic lymphocytes promotes liver fibrosis through modification of T helper cytokine balance in mice2015
Author(s)
Tanabe K, Taura K, Koyama Y, Yamamoto G, Nishio T, Okuda Y, Nakamura K, Toriguchi K, Takemoto K, Yamanaka K, Iwaisako K, Seo S, Asagiri M, Hatano E, Uemoto S.
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Journal Title
Journal of Gastroenterology
Volume: in press
Issue: 10
Pages: 1054-1068
DOI
Related Report
Peer Reviewed
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[Journal Article] Necrostatin-1 protects against reactive oxygen species (ROS)-induced hepatotoxicity in acetaminophen-induced acute liver failure.2014
Author(s)
Takemoto K, Hatano E, Iwaisako K, Takeiri M, Noma N, Ohmae S, Toriguchi K, Tanabe K, Tanaka H, Seo S, Taura K, Machida K, Takeda N, Saji S, Uemoto S, Asagiri M.
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Journal Title
FEBS Open Bio
Volume: 4
Issue: 1
Pages: 777-787
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Origin of myofiblasts in the fibrotic liver in mice2014
Author(s)
K.Iwaisako, C.Jiang, M.Zhang, M.Cong, T.J.Moore-Morris, T.J.Park, X.Liu, J.Xu, P.Wang, Y-H.Paik, F.Meng, M.Asagiri, L.A.Murray, A.F.Hofmann, T.Iida, C.K.Glass, D.A.Brenner, T.Kisseleva
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Journal Title
Proc. Natl. Acad. Sci. USA.
Volume: 111
Issue: 32
DOI
Related Report
Peer Reviewed
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[Journal Article] Generation of a mouse model with down-regulated U50 snoRNA (SNORD50) expression and its organ-specific phenotypic modulation2013
Author(s)
Soeno Y, Fujita K, Kudo T, Asagiri M, Kakuta S, Taya Y, Shimazu Y, Sato K, Tanaka-Fujita R, Kubo S, Iwakura Y, Nakamura Y, Mori S, and Aoba T
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Journal Title
PLoS ONE
Volume: 8
Issue: 8
Pages: e72105-e72105
DOI
Related Report
Peer Reviewed
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[Presentation] 薬剤性劇症肝炎の病態形成における制御性壊死の関与2014
Author(s)
竹本研史, 波多野悦朗, 祝迫惠子, 竹入雅敏, 野間成人, 鳥口寛, 田邉和孝, 瀬尾智, 田浦康二朗, 朝霧成挙, 上本伸二
Organizer
第35回日本炎症・再生医学会
Place of Presentation
万国津梁館 (沖縄)
Year and Date
2014-07-01 – 2014-07-04
Related Report
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