| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2014: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2013: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Outline of Final Research Achievements |
Neural crest cells appear during embryogenesis and differentiate into various kinds of cells, which reside as stem cells even after growth. Thus, neural crest stem cells are expected to be used as cell source for regenerative medicine. However, precise locarization of neural crest-derived cells has not been known. In this study, we tried to identify new cell populations that derived from neural crest by using double transgenic mice in which neural crest-derived cells are labeled with a green fluorescence protein. We found that a part of keratinocytes are derived from neural crest cells but not epidermal stem cells. These findings suggest that neural crest-derived cells in the epidermal tissues may be useful for regenerative medicine.
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