Identification of neural crest-derived cells to use for the analysis of disease mechanism and regenerative medicine
Project/Area Number |
24659830
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Research Category |
Grant-in-Aid for Challenging Exploratory Research
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Allocation Type | Multi-year Fund |
Research Field |
Functional basic dentistry
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Research Institution | Showa University |
Principal Investigator |
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Project Period (FY) |
2012-04-01 – 2015-03-31
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Project Status |
Completed (Fiscal Year 2014)
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Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2014: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2013: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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Keywords | 再生 / 神経堤 / 骨 / 細胞分化 / 幹細胞 / 骨芽細胞 / 上皮細胞 / マウス / 破骨細胞 / 遺伝子 / 再生医療 / 口腔 / バイオテクノロジー |
Outline of Final Research Achievements |
Neural crest cells appear during embryogenesis and differentiate into various kinds of cells, which reside as stem cells even after growth. Thus, neural crest stem cells are expected to be used as cell source for regenerative medicine. However, precise locarization of neural crest-derived cells has not been known. In this study, we tried to identify new cell populations that derived from neural crest by using double transgenic mice in which neural crest-derived cells are labeled with a green fluorescence protein. We found that a part of keratinocytes are derived from neural crest cells but not epidermal stem cells. These findings suggest that neural crest-derived cells in the epidermal tissues may be useful for regenerative medicine.
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Report
(4 results)
Research Products
(26 results)
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[Journal Article] Expression of nephronectin is inhibited by oncostatin M via both JAK/STAT and MAPK pathways2015
Author(s)
Kurosawa T, Yamada A, Takami M, Suzuki D, Saito Y, Hiranuma K, Enomoto T, Morimura N, Yamamoto M, Iijima T, Shirota T, Itabe H, Kamijo R.
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Journal Title
FEBS Open Bio
Volume: 5
Issue: 1
Pages: 303-307
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Porphyromonas gingivalis-derived lysine gingipain enhances osteoclast differentiation induced by tumor necrosis factor and interleukin-1 but suppresses that by interleukin-17: Importance of proteolytic degradation of osteoprotegerin by lysine gingipain.2014
Author(s)
Tomohito Akiyama, Yoichi Miyamoto, Kentaro Yoshimura, Atsushi Yamada, Masamichi Takami, Tetsuo Suzawa, Marie Hoshino, Takahisa Imamura, Chie Akiyama, Rika Yasuhara, Kenji Mishima, Toshifumi Maruyama, Chikara Kohda, Kazuo Tanaka, Jan Potempa, Hisataka Yasuda, Kazuyoshi Baba, Ryutaro Kamijo.
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Journal Title
J.Biol.Chem.
Volume: 289
Issue: 22
Pages: 1-35
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Secretion of a truncated osteopetrosis-associated transmembrane protein 1 (OSTM1) mutant inhibits osteoclastogenesis through down-regulation of the B lymphocyte-induced maturation protein 1 (BLIMP1)-nuclear factor of activated T cells c1 (NFATc1) axis2014
Author(s)
Shin B, Yu J, Park ES, Choi S, Yu J, Hwang JM, Yun H, Chung YH, Hong KS, Choi JS, Takami M, Rho J.
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Journal Title
J Biol Chem
Volume: 289
Issue: 52
Pages: 35868-35881
DOI
Related Report
Peer Reviewed
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[Journal Article] Octacalcium phosphate suppresses chondrogenic differentiation of ATDC5 cells.2013
Author(s)
I Shibuya, K Yoshimura, Y Miyamoto, A Yamada, M Takami, T Suzawa, D Suzuki, N Ikumi, F Hiura, T Anada, O Suzuki, R Kamijo.
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Journal Title
Cell Tissue Res
Volume: 352
Issue: 2
Pages: 401-412
DOI
Related Report
Peer Reviewed
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[Journal Article] Downregulation of carbonic anhydrase IX promotes Col10a1 expression in chondrocytes2013
Author(s)
Maruyama T, Miyamoto Y, Yamamoto G, Yamada A, Yoshimura K, Suzawa T, Takami M, Akiyama T, Hoshino M, Iwasa F, Ikumi N, Tachikawa T, Mishima K, Baba K, Kamijo R
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Journal Title
PLoS ONE
Volume: Vol.8
Issue: 2
Pages: e56984-e56984
DOI
Related Report
Peer Reviewed
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[Journal Article] R848, a toll-like receptor 7 agonist, inhibits osteoclast differentiation but not survival or bone-resorbing function of mature osteoclasts2012
Author(s)
Miyamoto A, Takami M, Matsumoto A, Mochizuki A, Yamada T, Tachi K, Shibuya I, Nakamach, T, Shioda S, Baba K, Inoue T, Miyamoto Y, Yim M, Kamijo R
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Journal Title
Cytotechnology
Volume: 64
Issue: 3
Pages: 331-339
DOI
Related Report
Peer Reviewed
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[Journal Article] BMP2 differentially regulates the expression of Gremlin1 and Gremlin2, the negative regulators of BMP function, during osteoblast differentiation2012
Author(s)
Suzuki D, Yamada A, Aizawa R, Funato S, Matsumoto T, Suzuki W, Takami M, Miyamoto Y, Suzawa T, Yamamoto M, Baba K, Kamijo R
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Journal Title
Calcif Tissue Int
Volume: 91
Issue: 1
Pages: 88-96
DOI
Related Report
Peer Reviewed
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[Book] The New frontiers in oral cancer2012
Author(s)
Masamichi Takami, Arei Miyamoto, Akifumi Matsumoto, Ayako Mochizuki, Kazuyoshi Baba, Tomio Inoue, Mijung Yim, Ryutaro Kamijo
Total Pages
209
Publisher
Maruzen Planet
Related Report
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