| Project/Area Number |
24659834
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Pathobiological dentistry/Dental radiology
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| Research Institution | Tohoku University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
KODAMA Tetsuya 東北大学, 医工学研究科, 教授 (40271986)
IIKUBO Masahiro 東北大学, 歯学研究科, 講師 (80302157)
KOJIMA Ikuho 東北大学, 歯学研究科, 助教 (80447169)
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| Co-Investigator(Renkei-kenkyūsha) |
MORI Shiro 東北大学, 大学病院, 講師 (80230069)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2014: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | ナノバブル / 超音波 / リンパネットワーク / 画像解析 / リンパ節 / リンパ節転移 / 画像診断 / センチネルリンパ節 |
|---|
| Outline of Final Research Achievements |
The aim of this study is to develop a new diagnostic imaging technique which can detect the head and neck cancer metastasis routes. In this study, MXH10 / Mo / lpr mice, which develop systemic swelling of lymph nodes up to 10 mm in diameter, were used as a lymph node metastasis model. As a method for visualization of lymph node network in real time, we examined a contrast ultrasound imaging system using nano-microbubbles. As a result, it was suggested that contrast ultrasound image analysis method using a nano-micro-bubbles might be a potential method clinically applicable to detection of lymphatic network.
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