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Establishment of new jawbone healing evaluation in the old and middle age patient of jaw deformity after surgery

Research Project

Project/Area Number 24659892
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeSingle-year Grants
Research Field Surgical dentistry
Research InstitutionOkayama University

Principal Investigator

TSUYOSHI Shimo  岡山大学, 医歯(薬)学総合研究科, 准教授 (40362991)

Co-Investigator(Kenkyū-buntansha) NISHIYAMA Akiyoshi  岡山大学, 大学病院, 講師 (50189320)
YOSHIOKA Norie  岡山大学, 大学院医歯薬学総合研究科, 助教 (50362984)
Project Period (FY) 2012-04-01 – 2014-03-31
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywords骨折 / 顎変形症 / ソニックヘッジホッグ
Research Abstract

The process of jawbone healing in the postoperative jaw deformity has many vague points, and it is the present conditions until now that set the fixed term between a different intermaxillary fixation between facilities. Previously, we have reported that the sonic hedgehog (SHH) participated in the bone formation and resorption. In this study, we examined the distribution patterns of SHH and the role during fracture healing. Furthermore, I do the usefulness of the hedgehog as the bone metabolism marker after the surgery of jaw deformity and am aimed for establishment pro-new jawbone healing evaluation.
(This study was I carried out with Okayama University Ethical Review Board approval.)

Report

(3 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • Research Products

    (12 results)

All 2013 2012 Other

All Journal Article (1 results) (of which Peer Reviewed: 1 results) Presentation (8 results) Remarks (3 results)

  • [Journal Article] Sonic Hedgehog Regulates Osteoblast Function by Focal Adhesion Kinase Signaling in the Process of Fracture Healing2013

    • Author(s)
      Yuu Horikiri, Tsuyoshi Shimo, Naito Kurio, Tatsuo Okui, Kenichi Matsumoto, Masahiro Iwamoto, Akira Sasaki
    • Journal Title

      PLoS One

      Volume: 8(10) Issue: 10 Pages: e76785-e76785

    • DOI

      10.1371/journal.pone.0076785

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Presentation] Focal adhesion kinase and sonic hedgehog regulate osteoblast and osteoclast function in the process of fracture healing2013

    • Author(s)
      Yuu Horikiri,Tsuyoshi Shimo,Masahiro Iwamoto,Naito Kurio,Tatsuo Okui,Akira Sasaki
    • Organizer
      The 6th International Symposium for Future Technology Creating Better Human Health and Society Strategy to Establish the System for the Developement of Drug
    • Place of Presentation
      Okayama,Japan
    • Year and Date
      2013-02-08
    • Related Report
      2013 Final Research Report
  • [Presentation] The role of Focal adhesion kinase and Sonic hedgehog on the process of fracture repair2013

    • Author(s)
      Yuu Horikiri,Tsuyoshi Shimo,Masahiro Iwamoto,Naito Kurio,Tatsuo Okui,Akira Sasaki
    • Organizer
      The International Bone and Mineral Society (IBMS)
    • Place of Presentation
      Kobe,Japan
    • Related Report
      2013 Final Research Report
  • [Presentation] Sonic hedgehog-focal adhesion kinase signaling regulates the process of fracture repair2013

    • Author(s)
      Kenichi Matsumoto,Yuu Horikiri,Tsuyoshi Shimo,Naito Kurio,Tatsuo Okui,Hiromasa Kuroda,Akira Sasaki
    • Organizer
      The third international symposium of medical-dental-pharmaceutical education and research in okayama
    • Place of Presentation
      Okayama,Japan
    • Related Report
      2013 Final Research Report
  • [Presentation] The role of Focal adhesion kinase and Sonic hedgehog on the process of fracture repair2013

    • Author(s)
      Yuu Horikiri, Tsuyoshi Shimo, Masahiro Iwamoto, Naito Kurio, Tatsuo Okui, Akira Sasaki
    • Organizer
      The International Bone and Mineral Society (IBMS)
    • Place of Presentation
      Kobe, Japan
    • Related Report
      2013 Annual Research Report
  • [Presentation] Sonic hedgehog-focal adhesion kinase signaling regulates the process of fracture repair2013

    • Author(s)
      Kenichi Matsumoto, Yuu Horikiri, Tsuyoshi Shimo, Naito Kurio, Tatsuo Okui, Hiromasa Kuroda, Akira Sasaki
    • Organizer
      The third international symposium of medical-dental-pharmaceutical education and research in Okayama
    • Place of Presentation
      Okayama, Japan
    • Related Report
      2013 Annual Research Report
  • [Presentation] Focal adhesion kinase and sonic hedgehog regulate osteoblast and osteoclast function in the process of fracture healing2013

    • Author(s)
      Yuu Horikiri, Tsuyoshi Shimo, Masahiro Iwamoto, Naito Kurio, Tatsuo Okui, Akira Sasaki
    • Organizer
      The 6th International Symposium for Future Technology Creating Better Human Health and Society Strategy to Establish the System for the Developement of Drug
    • Place of Presentation
      Okayama
    • Related Report
      2012 Research-status Report
  • [Presentation] 骨折早期におけるFocal adhesion kinaseの役割2012

    • Author(s)
      堀切 優, 志茂 剛, 栗尾奈愛, 奥井達雄, 佐々木 朗
    • Organizer
      第60回NPO法人日本口腔科学会中国・四国地方部会
    • Place of Presentation
      広島
    • Related Report
      2012 Research-status Report
  • [Presentation] Focal adhesion kinaseの骨折早期における骨芽細胞に与える影響2012

    • Author(s)
      堀切 優, 志茂 剛, 栗尾奈愛, 奥井達雄, 佐々木 朗
    • Organizer
      第30回日本骨代謝学会学術集会
    • Place of Presentation
      東京
    • Related Report
      2012 Research-status Report
  • [Remarks] 岡山大学プレスリリース

    • URL

      https://www.okayama-u.ac.jp/tp/release/releaseid120.html

    • Related Report
      2013 Final Research Report
  • [Remarks] 日刊工業新聞

    • URL

      http://www.nikkan.co.jp/news/nkx1020131205eaah.html

    • Related Report
      2013 Final Research Report
  • [Remarks] 骨折治癒へのソニックヘッジホッグの関与を解明

    • URL

      https://www.okayama-u.ac.jp/tp/release/release_id120.html

    • Related Report
      2013 Annual Research Report

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Published: 2013-05-31   Modified: 2019-07-29  

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