| Project/Area Number |
24659911
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Orthodontic/Pediatric dentistry
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| Research Institution | Hiroshima University |
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Principal Investigator |
KOZAI Katsuyuki 広島大学, 大学院医歯薬保健学研究院, 教授 (10178212)
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| Co-Investigator(Kenkyū-buntansha) |
MITSUHATA Chieko 広島大学, 大学院医歯薬保健学研究院, 准教授 (10335664)
OHHARA Yukari 広島大学, 大学院医歯薬保健学研究院, 助教 (80634469)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2014: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | mutans streptococci / 齲蝕 / 細菌の生育環境 / デグラドゾーム / 環境適応 / Streptococcus mutans / Degradosome / Biofilm |
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| Outline of Final Research Achievements |
The purpose of this study is to make sure that the formation of multiprotein complex called degradosome and the control should be performed as a method of adaptation of living environment in biofilm of cariogenic mutans streptococci. Firstly, the experiment of seeking some protein producing MS complex of a center of enolase was performed. The cDNA was made by cloning of enolase and recognition of DNA sequence was done. The results showed that the point mutation was found to UA159 in all strains. In two starins, it is found that some amino acids are different.
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