Mechanism of androgen production in skeletal muscle and muscle atrophy suppression

• Project/Area Number: 24680070
• Research Category: Grant-in-Aid for Young Scientists (A)
• Allocation Type: Partial Multi-year Fund
• Research Field: Sports science
• Research Institution: Senshu University
• Principal Investigator: AIZAWA katsuji 専修大学, 文学部, 准教授 (80375477)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥27,430,000 (Direct Cost: ¥21,100,000、Indirect Cost: ¥6,330,000); Fiscal Year 2014: ¥6,110,000 (Direct Cost: ¥4,700,000、Indirect Cost: ¥1,410,000); Fiscal Year 2013: ¥6,890,000 (Direct Cost: ¥5,300,000、Indirect Cost: ¥1,590,000); Fiscal Year 2012: ¥14,430,000 (Direct Cost: ¥11,100,000、Indirect Cost: ¥3,330,000)
• Keywords: アンドロゲン / サルコペニア / 骨格筋 / 自己分泌 / 身体運動

Outline of Final Research Achievements

It is believed that dihydrotestosterone (DHT) is the most powerful androgen converted by testosterone through 5α-reductase (srd5a1). However, it remains to be elucidated whether muscular DHT production through srd5a1 is locally involved in skeletal muscular plasticity. Here we found that local DHT production in skeletal muscle induced muscular hypertrophy with acceleration of the protein synthesis and inhibited muscular atrophy through the suppression of atrophy-related gene expression. Transcriptional regulation of srd5a1 is controlled by early growth response2 (egr2). These observations indicate that bioactive androgen production through srd5a1 locally play an important role in skeletal muscle metabolism.

Research Products

• [Journal Article] MicroRNA-23a has minimal effect on endurance exercise-induced adaptation of mouse skeletal muscle. (2015)
  • Author(s): Shogo. Wada, Yoshio. Kato, Shuji. Sawada, Katsuji Aizawa, J.H. Park, A.P. Russell, Takashi Ushida, Takayuki Akimoto.
  • Journal Title: European Journal of Physiology Volume: 467 Pages: 389-398
  • Peer Reviewed
• [Journal Article] Dehydroepiandrosterone administration increased trabecular mass and dihydrotestosterone levels in the cancellous region of the tibia in young female rats (2014)
  • Author(s): J.H. Park, Katsuji Aizawa, Takayuki Akimoto, Motoyuki Iemitsu, Umon Agata, Seiji Maeda, K Lim, Naomi Omi.
  • Journal Title: Horm Metab Res Volume: 46 Issue: 09 Pages: 651-655
  • DOI: 10.1055/s-0034-1374630
  • Peer Reviewed
• [Journal Article] Skeletal muscle adaptation in response to mechanical stress in p130Cas－/－ mice (2013)
  • Author(s): Takayuki Akimoto, Kanako Okuhira, Katsuji Aizawa, Shogo Wada, Hiroaki Honda, Toru Fukubayashi, Takashi Ushida.
  • Journal Title: Am J Physiol Cell Physiol. Volume: 304(6) Issue: 6 Pages: 541-547
  • DOI: 10.1152/ajpcell.00243.2012
  • Peer Reviewed
• [Journal Article] Effects of regular aerobic exercise on post-exercise vagal reactivation in young female. (2013)
  • Author(s): Mariko Nakamura , Koichiro Hayashi, Katsuji Aizawa, Noboru Mesaki, Ichiro Kono.
  • Journal Title: European Journal of Sport Science. Eur J Sport Sci. Volume: 13(6) Issue: 6 Pages: 674-680
  • DOI: 10.1080/17461391.2013.774054
  • Peer Reviewed
• [Journal Article] DHEA administration and exercise training improves insulin resistance in obese rats (2012)
  • Author(s): Koji Sato, Motoyuki Iemitsu, Katsuji Aizawa, Noboru Mesaki, Ryuichi Ajisaka, Satoshi Fujita
  • Journal Title: Nutrition & Metabolism Volume: 30巻 Pages: 47-47
  • NAID: 120006352258
  • Peer Reviewed
• [Journal Article] Mucosal immune function comparison between amenorrheic and eumenorrheic distance runners (2012)
  • Author(s): Kazuhiro Shimizu, Natsumi Suzuki, Mariko Nakamura, Katsuji Aizawa, Tomoko Imai, Satomi Suzuki, Nobuhiko Eda, Yukichi Hanaoka, Kikuko Nakao, Naoto Suzuki, Noboru Mesaki, Ichiro Kono, Takao Akama.
  • Journal Title: Journal of Strength and Conditioning Research Volume: 26巻 Pages: 1402-1406
  • Peer Reviewed
• [Journal Article] 女性アスリートの医科学的サポートを考える : 女性アスリートの筋力増強 (2012)
  • Author(s): 相澤勝治
  • Journal Title: 臨床スポーツ医学 Volume: 30巻 Pages: 167-171
• [Journal Article] 運動とは何か : 性ホルモンと運動 (2012)
  • Author(s): 相澤勝治, 目崎 登
  • Journal Title: 公衆衛生 Volume: 76巻 Pages: 448-451
• [Presentation] メカニカルストレスを介した活性型アンドロゲンによる筋萎縮抵抗性 (2014)
  • Author(s): 相澤勝治, 目崎 登, 牛田多加志, 秋本崇之
  • Organizer: 第69回日本体力医学会
  • Place of Presentation: 長崎
  • Year and Date: 2014-09-19 – 2014-09-21
• [Presentation] MicroRNA-23aは持久性運動による筋適応に関与しない (2014)
  • Author(s): 秋本崇之, 和田正吾, 加藤義雄, 沢田秀司, 相澤勝治, 朴 鍾薫, 牛田多加志
  • Organizer: 第69回日本体力医学会
  • Place of Presentation: 長崎
  • Year and Date: 2014-09-19 – 2014-09-21
• [Presentation] 筋局所アンドロゲン産生を介した高齢期の筋機能改善メカニズム (2014)
  • Author(s): 相澤勝治, 家光素行, 佐藤幸治, 目崎 登
  • Organizer: 日本体育学会弟65回大会
  • Place of Presentation: 岩手
  • Year and Date: 2014-08-26 – 2014-08-28
• [Presentation] 性ホルモン分泌器官としての骨格筋の可能性 (2014)
  • Author(s): 相澤勝治
  • Organizer: 第22回日本運動生理学会大会
  • Place of Presentation: 岡山
  • Year and Date: 2014-07-19 – 2014-07-20
  • Invited
• [Presentation] The effect of local bioactive androgen production on skeletal muscular hypertrophy. (2013)
  • Author(s): Katsuji. Aizawa, Shogo. Wada, Takashi. Ushida, Takayuki. Akimoto.
  • Organizer: 18th annual congress of the european college of sports science
  • Place of Presentation: スペイン・バルセロナ
• [Presentation] 筋萎縮抵抗性における筋局所活性型ア ンドロゲンの役割 (2013)
  • Author(s): 相澤勝治，和田正吾，目崎 登，牛田多加志，秋本崇之．
  • Organizer: 第68回日本体力医学会
  • Place of Presentation: 東京
• [Presentation] 性ステロイドホルモン投与と運動トレーニングが高ショ糖食摂取による肥満ラット (2012)
  • Author(s): 佐藤幸治, 家光素行, 相澤勝治, 目崎 登, 藤田 聡
  • Organizer: 第25回日本トレーニング科学会大会
  • Place of Presentation: 立命館大学
  • Year and Date: 2012-12-01
• [Presentation] 身体運動によるヘルスベネフィットのメカニズムを探る.身体運動による筋局所アンドロゲン産生を介した骨格筋肥大のメカニズム (2012)
  • Author(s): 相澤勝治
  • Organizer: 第67回日本体力医学会
  • Place of Presentation: 長良川国際会議場
  • Year and Date: 2012-09-15
• [Book] ニュー運動生理学．第14章： 運動と内分泌： 性ホルモンと骨格筋適応 (2015)
  • Author(s): 相澤勝治
  • Total Pages: 414
  • Publisher: 真興交易医書出版部
• [Book] Basic Biology and Current Understanding of Skeletal Muscle. Chapter 10. Skeletal Muscle Adaptation and Local Steroidogenesis. (2013)
  • Author(s): Katsuji Aizawa, Kunihiro Sakuma
  • Total Pages: 318
  • Publisher: NOVA Publishers
• [Book] 運動と栄養：健康づくりのための実践指導．第6章：運動と内分泌系. (2013)
  • Author(s): 相澤勝治,上田伸男,岸恭一,塚原丘美
  • Total Pages: 207
  • Publisher: 講談社
• [Book] 月刊スポーツメディスン9・10月合併号.身体運動の価値を分子レベルから解明する：骨格筋が性ホルモンを産生する意味とは． (2013)
  • Author(s): 相澤勝治
  • Total Pages: 60
  • Publisher: ブックハウス・エイチディ
• [Book] Current Research Trends in Skeletal Muscle ; The role of steroidogenesis in skeletal muscle (2012)
  • Author(s): Katsuji Aizawa
  • Publisher: Research Signpost