Roles of cabohydrates in protozoan infection
Project/Area Number |
24688032
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Research Category |
Grant-in-Aid for Young Scientists (A)
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Allocation Type | Partial Multi-year Fund |
Research Field |
Applied veterinary science
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Research Institution | Obihiro University of Agriculture and Veterinary Medicine |
Principal Investigator |
KATO Kentaro 帯広畜産大学, 原虫病研究センター, 特任准教授 (30401178)
|
Project Period (FY) |
2012-04-01 – 2016-03-31
|
Project Status |
Completed (Fiscal Year 2015)
|
Budget Amount *help |
¥26,650,000 (Direct Cost: ¥20,500,000、Indirect Cost: ¥6,150,000)
Fiscal Year 2014: ¥8,970,000 (Direct Cost: ¥6,900,000、Indirect Cost: ¥2,070,000)
Fiscal Year 2013: ¥8,840,000 (Direct Cost: ¥6,800,000、Indirect Cost: ¥2,040,000)
Fiscal Year 2012: ¥8,840,000 (Direct Cost: ¥6,800,000、Indirect Cost: ¥2,040,000)
|
Keywords | 原虫 / 糖鎖 / 宿主細胞侵入 / 感染 / 抗原虫薬 |
Outline of Final Research Achievements |
We got the results of roles of cabohydrates in protozoan infection as described below. The host factors bound with protozoan secreted proteins have been detected. The polysaccharides have been sulfated to manufacture materials effective in the inhibition of infection. Using these sulfated polysaccharides, we analyzed the effects on invasion inhibition and growth inhibition. We have detected the protozoan proteins actually bound with the sulfated polysaccharides which can inhibit the protozoan growth. Therefore, we succeeded in analyzing roles of cabohydrates in protozoan infection.
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Report
(5 results)
Research Products
(67 results)
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[Journal Article] Molecular epidemiological analyses of Cryptosporidium parvum virus 1 (CSpV1), asymbiotic virus of Cryptosporidium parvum, in Japan2016
Author(s)
Murakoshi F, Ichikawa-Seki M, Aita J, Yaita S, Kinami A, Fujimoto K, Nishikawa Y, Murakami S, Horimoto T, Kato K.
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Journal Title
Virus Res.
Volume: 211
Pages: 69-72
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Lambda-carrageenan treatment exacerbates the severity of cerebral malaria caused by Plasmodium berghei ANKA in BALB/c mice.2014
Author(s)
Recuenco FC, Takano R, Chiba S, Sugi T, Takemae H, Murakoshi F, Ishiwa A, Inomata A, Horimoto T, Kobayashi Y, Horiuchi N, Kato K.
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Journal Title
Malar J.
Volume: 13
Issue: 1
Pages: 487-487
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Interaction between Theileria orientalis 23-kDa piroplasm membrane protein and heparin.2014
Author(s)
Takemae H, Sugi T, Kobayashi K, Murakoshi F, Gong H, Recuenco FC, Ishiwa A, Inomata A, Horimoto T, Yokoyama N, Kato K (corresponding author).
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Journal Title
Jpn J Vet Res.
Volume: 62
Pages: 17-24
NAID
Related Report
Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
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[Journal Article] Gellan sulfate inhibits Plasmodium falciparum growth and invasion of red blood cells in vitro.2014
Author(s)
Recuenco FC, Kobayashi K, Ishiwa A, Enomoto-Rogers Y, Fundador NGV, Sugi T, Takemae H, Iwanaga T, Murakoshi F, Gong H, Inomata A, Horimoto T, Iwata T, Kato K (corresponding author).
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Journal Title
Sci Rep. (Nature Publishing Group)
Volume: 4
Issue: 1
Pages: 4723-4723
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Characterization of the interaction between Toxoplasma gondii rhoptry neck protein 4 and host cellular β-tubulin.2013
Author(s)
Takemae H, Sugi T, Kobayashi K, Gong H, Ishiwa A, Recuenco FC, Murakoshi F, Iwanaga T, Inomata A, Horimoto T, Akashi H, Kato K (corresponding author).
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Journal Title
Sci Rep. (Nature Publishing Group)
Volume: 3
Issue: 1
Pages: 3199-3199
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Patent(Industrial Property Rights)] 抗原虫薬2015
Inventor(s)
加藤健太郎、アラー テルカウィ、高野量
Industrial Property Rights Holder
国立大学法人帯広畜産大学
Industrial Property Rights Type
特許
Industrial Property Number
2015-233632
Filing Date
2015-11-30
Related Report
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