New developments in the treatment and diagnosis of the esophageal cancer based on the analysis of epigenetic modifications
| Project/Area Number |
24689053
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| Research Category |
Grant-in-Aid for Young Scientists (A)
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| Allocation Type | Partial Multi-year Fund |
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| Research Field |
Digestive surgery
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| Research Institution | Chiba University |
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Principal Investigator |
HOSHINO Isamu 千葉大学, 医学(系)研究科(研究院), 特任研究員 (10400904)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥22,620,000 (Direct Cost: ¥17,400,000、Indirect Cost: ¥5,220,000)
Fiscal Year 2014: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
Fiscal Year 2013: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
Fiscal Year 2012: ¥10,920,000 (Direct Cost: ¥8,400,000、Indirect Cost: ¥2,520,000)
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| Keywords | エピジェネティクス / microRNA / ヒストン修飾 / 食道扁平上皮癌 / LSD1阻害剤 / 分子標的治療 / LSD１阻害剤 / エピジェネティク / LSD阻害剤 |
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| Outline of Final Research Achievements |
We focused on microRNA (miR) and histone methylation. Serum expression level of miR-1246 was significantly higher and it showed usefulness as a new biomarker in esophageal cancer patients. MiR-1246 was secreted from cancer cells by exosome and could participates in cancer progression. We confirmed that miR-375 which expression was attenuated in esophageal cancer tissues by miR expression profiling had a strong antitumor effect, and it could become a new treatment tool. It was shown that histone modification participated in expression of miR-375. NCL1 which was histone demethylase inhibitor had a strong antitumor effect, and it could be a new molecular target agent.
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Report
(4 results)
Research Products
(16 results)
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[Journal Article] Detection of Peritoneal Dissemination with Near-infrared Fluorescence Laparoscopic Imaging Using a Liposomal Formulation of a Synthesized Indocyanine Green Liposomal Derivative.2015
Author(s)
Hoshino I, Maruyama T, Fujito H, Tamura Y, Suganami A, Hayashi H, Toyota T, Akutsu Y, Murakami K, Isozaki Y, Akanuma N, Takeshita N, Toyozumi T, Komatsu A, Matsubara H.
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Journal Title
Anticancer Res.
Volume: 35
Pages: 1353-1359
Related Report
Peer Reviewed
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[Journal Article] Histone Demethylase LSD1 Inhibitors Prevent Cell Growth by Regulating Gene Expression in Esophageal Squamous Cell Carcinoma Cells.2015
Author(s)
Hoshino I, Akutsu Y, Murakami K, Akanuma N, Isozaki Y, Maruyama T, Toyozumi T, Matsumoto Y, Suito H, Takahashi M, Sekino N, Komatsu A, Suzuki T, Matsubara H.
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Journal Title
Ann Surg Oncol.
Volume: -
Related Report
Peer Reviewed
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[Journal Article] Screening of alternative drugs to the tumor suppressor miR-375 in esophageal squamous cell carcinoma using the connectivity map.2014
Author(s)
Isozaki Y, Hoshino I, Akutsu Y, Hanari N, Mori M, Nishimori T, Murakami K, Akanuma N, Toyozumi T, Takahashi M, Suito H, Takeshita N, Maruyama T, Suzuki A, Nakayama T, Matsubara H.
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Journal Title
Oncology.
Volume: 87
Issue: 6
Pages: 351-363
DOI
Related Report
Peer Reviewed
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[Journal Article] Usefulness of microRNA-375 as a prognostic and therapeutic tool in esophageal squamous cell carcinoma.2014
Author(s)
Isozaki Y, Hoshino I, Akutsu Y, Hanari N, Mori M, Nishimori T, Murakami K, Akanuma N, Takeshita N, Maruyama T, Toyozumi T, Takahashi M, Suito H, Matsubara H.
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Journal Title
Int J Oncol.
Volume: 46
Issue: 3
Pages: 1059-66
DOI
Related Report
Peer Reviewed
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