Identification and functional analyses of memory-encoded cells in Drosophila
| Project/Area Number |
24700310
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Neuroscience in general
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| Research Institution | The University of Tokyo |
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Principal Investigator |
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | CREB / 記憶 / ショウジョウバエ / キノコ体 / 記憶学習 |
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| Research Abstract |
CREB is an essential transcriptional factor for long-term memory. We constructed some types of CREB reporter genes and generated CREB reporter flies. We found that these reporters strongly labeled the mushroom bodies, central structures for olfactory learning and memory. As the result of functional analysis of these neurons, output from gamma neurons in the mushroom bodies are indispensable for not only long-term memory, but short-term memory at any steps. It has been shown that CREB would have a role only in long-term memory, because long-term memory requires de novo protein synthesis. However, CREB-activated cells seem to be also involved in short-term memory.
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Report
(3 results)
Research Products
(4 results)
