Regulated processing of neuregulin1 precursors in rat cortical neurons
| Project/Area Number |
24700375
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Neurochemistry/Neuropharmacology
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| Research Institution | Niigata University |
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Principal Investigator |
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2012: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | 神経細胞 / ニューレグリン１ / グルタミン酸受容体 / メタロプロテアーゼ / 大脳皮質 / ErbB4 |
|---|
| Research Abstract |
Neuregulin1 (NRG1) belongs to the family of epidermal growth factor (EGF) and is implicated in synaptic plasticity of glutamatergic transmission and neuronal and glial development. Recent genetic studies also indicate the association of this gene with a schizophrenia risk. However, the regulation of NRG1 processing and release in brain is poorly understood. Here we examined glutamate neurotransmission has a regulatory role in NRG1 processing and release in the central nervous system.
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Report
(3 results)
Research Products
(5 results)
