Regulated processing of neuregulin1 precursors in rat cortical neurons

• Project/Area Number: 24700375
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Neurochemistry/Neuropharmacology
• Research Institution: Niigata University
• Principal Investigator: IWAKURA Yuriko 新潟大学, 脳研究所, 助教 (40452081)
• Project Period (FY): 2012-04-01 – 2014-03-31
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000); Fiscal Year 2012: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
• Keywords: 神経細胞 / ニューレグリン１ / グルタミン酸受容体 / メタロプロテアーゼ / 大脳皮質 / ErbB4

Research Abstract

Neuregulin1 (NRG1) belongs to the family of epidermal growth factor (EGF) and is implicated in synaptic plasticity of glutamatergic transmission and neuronal and glial development. Recent genetic studies also indicate the association of this gene with a schizophrenia risk. However, the regulation of NRG1 processing and release in brain is poorly understood. Here we examined glutamate neurotransmission has a regulatory role in NRG1 processing and release in the central nervous system.

Research Products

• [Journal Article] ErbB1-4-dependent EGF/neuregulin signals and their cross talk in the central nervous system: pathological implications in schizophrenia and Parkinson's disease. (2013)
  • Author(s): Iwakura Y
  • Journal Title: Front Cell Neurosci Volume: 7 Pages: 4-4
  • DOI: 10.3389/fncel.2013.00004
  • Peer Reviewed
• [Presentation] 細胞外ドメインのシェディングを介した、EGFファミリーと神経伝達物質のクロストーク (2014)
  • Author(s): 岩倉百合子
  • Organizer: 新潟脳研―生理研合同シンポジウム
  • Place of Presentation: 愛知県岡崎市
  • Year and Date: 2014-02-26
• [Presentation] 細胞外ドメインのシェディングを介した、EGFファミリーと神経伝達物質のクロストーク (2014)
  • Author(s): 岩倉百合子
  • Organizer: 第3回新潟大学脳研究所ー生理学研究所合同シンポジウム
  • Place of Presentation: 岡崎カンファレンスセンター
  • Invited
• [Presentation] Regulated processing of neuregulin-1 precursors in rat cortical neurons (2012)
  • Author(s): Iwakura Y, Wang R, Araki K, Tanemura S, Nawa H.
  • Organizer: 第35回日本分子生物学会年会
  • Place of Presentation: 福岡県福岡市
  • Year and Date: 2012-12-13
• [Presentation] Regulated processing of neuregulin-1 precursors in rat cortical neurons (2012)
  • Author(s): 岩倉百合子
  • Organizer: 日本分子生物学会年会
  • Place of Presentation: 福岡国際会議場・マリンメッセ福岡