Analysis of decellularized small diameter blood vessel that has anti-thrombus and its application to small diameter artificial blood vessel
| Project/Area Number |
24700458
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Biomedical engineering/Biological material science
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| Research Institution | Tokyo Medical and Dental University (2014)
Sapporo Medical University (2012-2013) |
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Principal Investigator |
FUNAMOTO SEIICHI 東京医科歯科大学, 生体材料工学研究所, 准教授 (40609947)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2014: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2012: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | バイオマテリアル / 循環器 / 脱細胞化組織 / 組織工学 / 循環器領域 / 組織再生 |
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| Outline of Final Research Achievements |
Intravascular lumen is composed of basement membrane called tissue and endothelial cells. Vascular endothelial cells have the function of anti-thrombotic. Early Vascular -endothelialization due to maintenance of basement membrane structure of decellularized blood vessel is important for the maintenance of blood flow of small-diameter vascular graft. In this project was to evaluate the decellularized vascular lumen structure. Also explored the relationship of the basement membrane structure and endothelial cell function performs a vascular endothelial cell seeding to the decellularized vascular lumen. As the results, tissue regeneration by cell infiltration after transplantation has been observed. Decellularized small-diameter artery was not recognized early thrombus formation and constriction.
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Report
(4 results)
Research Products
(18 results)
