Thioredoxin is a myokine secreted by skeletal muscle
Project/Area Number |
24700700
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Sports science
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Research Institution | Tokyo Metropolitan University |
Principal Investigator |
MANABE YASUKO 首都大学東京, 人間健康科学研究科, 准教授 (60467412)
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Project Period (FY) |
2012-04-01 – 2014-03-31
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Project Status |
Completed (Fiscal Year 2013)
|
Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2013: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
|
Keywords | マイオカイン / 骨格筋 / 運動 / 筋収縮 / チオレドキシン |
Research Abstract |
This study investigated whether Thioredoxin (TRX) is one of the myokines secreted by skeletal muscle. Secretion of TRX was observed without any stimulation or with stimulation of the low intensity of electric pulse. On the other hand, that was increased with stimulation of the high intensity of electric pulse concomitantly with an increase in LDH activity, a marker of cell injury, suggesting that an increased secretion of TRX was attributed to the leakage due to the cell damages. We also studied whether TRX-1 was secreted via exosome vesicles, a major mechanism of unconventional secretion because TRX-1 is known as one of the secreted proteins without signal peptide sequence signaling. However, TRX-1 was not secreted via exosome vesicles. In summary, TRX is constitutively secreted myokine, but not regulated by the muscle contraction.
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Report
(3 results)
Research Products
(45 results)
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[Presentation] Macrophage migration inhibitory factor decreases glucose transport induced by insulin and AICAR in skeletal muscle2013
Author(s)
Shouta Miyatake, Yasuko Manabe, Akiko Inagaki, Yasuro Furuichi, Mayumi Takagi, Masato Taoka, Toshiaki Isobe, Kiichi Hirota, Kazunori Yasuda, Jun Nishihira, Nobuharu L. Fujii
Organizer
第36回日本分子生物学会
Place of Presentation
神戸
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[Presentation] anaxatriol Activates Insulin Signaling Pathway in Skeletal Muscle and Improves Insulin Resistance in KKAy Mice
Author(s)
Kitamura K, Takamura Y, Iwamoto T, Ikoma K, Nomura M, Sugioka H, Kobayashi T, Komada T, Manabe Y, Iwasaki H, Ohdera M, Fujii NL, Fushiki T
Organizer
72th Scientific Sessions American Diabetes Association
Place of Presentation
Orland
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