| Project/Area Number |
24700806
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Eating habits, studies on eating habits
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| Research Institution | University of Shizuoka |
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Principal Investigator |
SHIMAMURA YUKO 静岡県立大学, 食品栄養科学部, 助教 (60452025)
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2013: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
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| Keywords | 黄色ブドウ球菌 / ポリフェノール / エンテロトキシンA / ブドウ球菌エンテロトキシンA(SEA) / ブドウ球菌エンテロトキシンA |
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| Research Abstract |
The aims of the present study are first to investigate the binding activities of plant extracts and its components (n=136) to staphylococcal enterotoxin A (SEA), and second to examine the inhibitory effects of these extracts and components on the production and toxic activity of SEA. As a result, 26 samples inhibited the binding affinity of the anti-SEA antibody to SEA. Although highly polymerized proanthocyanidins in apple extract was bound with SEA directly, lowly polymerized proanthocyanidins inhibited the toxic activity without binding with SEA. Hydroxyl group at position 3 of galloyl group in catechin structure was responsible for binding affinity with the SEA. However methylated-catechins (methyl group at position 3 or 4 of galloyl group) showed inhibitory effect on production and toxic activity of SEA. It was suggested that these inhibitory effects were not necessarily related to the binding affinity of SEA.
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