Strategy for gout prevention based on pharmacodynamics and pharmacokinetics of antioxidants

• Project/Area Number: 24700819
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Eating habits, studies on eating habits
• Research Institution: Hokkaido University
• Principal Investigator: OGURA Jiro 北海道大学, 薬学研究科(研究院), 助教 (20580640)
• Project Period (FY): 2012-04-01 – 2014-03-31
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2013: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000); Fiscal Year 2012: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
• Keywords: 痛風 / BCRP / 抗酸化物質 / 薬力学的特性 / 薬物動態学的特性

Research Abstract

The purpose of this study is development of gout prevention targeting BCRP, which is a urate efflux transporter. We found that caffeic acid is effective in scavenging reactive oxygen species (ROS) derived from xanthine oxidase and NADPH oxidase. ROS derived from these oxidases can suppress BCRP S-S bond formation. Moreover, we found that accumulation of caffeic acid in intestinal epithelial cells was important for ROS scavenging activity of caffeic acid.

Research Products

• [Journal Article] Quercetin-3-rhamnoglucoside (rutin) stimulates transport of organic anion compounds mediated by organic anion transporting polypeptide 2B1. (2014)
  • Author(s): Ogura J, Koizumi T, Segawa M, Yabe K, Kuwayama K, Sasaki S, Kaneko C, Tsujimoto T, Kobayashi M, Yamaguchi H, Iseki K.
  • Journal Title: Biopharm Drug Dispos. Volume: 35 Issue: 3 Pages: 173-182
  • DOI: 10.1002/bdd.1882
  • Peer Reviewed
• [Presentation] (1st/7) Activation of xanthine oxidase suppresses excretion of uric acid to the intestinal lumen (2014)
  • Author(s): Ogura J, et al
  • Organizer: 17th Biennial Meeting of Society for Free Radical Research International
  • Place of Presentation: 京都(国立京都国際会館)
• [Presentation] Activation of xanthine oxidase suppresses excretion of uric acid to the intestinal lumen. (2014)
  • Author(s): Ogura J, Kuwayama K, Sasaki S, Kaneko C, Koizumi T, Yabe K, Iseki K.
  • Organizer: 17th Biennial Meeting of Society for Free Radical Research International
  • Place of Presentation: 京都 (国立京都国際会館）
• [Presentation] (1st/8) Activation of xanthine oxidase suppresses disulfide bond formation of breast cancer resistance protein in Caco-2 cells (2013)
  • Author(s): Ogura J, et al
  • Organizer: 10th International ISSX Meeting
  • Place of Presentation: Toronto (Westin Harbour Castle Hotel)
• [Presentation] Activation of xanthine oxidase suppresses disulfide bond formation of breast cancer resistance protein in Caco-2 cells. (2013)
  • Author(s): Ogura J, Sasaki S, Kuwayama K, Kaneko C, Koizumi T, Yabe K, Yamaguchi H, Iseki K.
  • Organizer: 10th International ISSX Meeting
  • Place of Presentation: Toronto (Westin Harbour Castle Hotel)