| Project/Area Number |
24700829
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Eating habits, studies on eating habits
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| Research Institution | The University of Tokushima |
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Principal Investigator |
OYADOMARI MIHO 徳島大学, 疾患プロテオゲノム研究センター, 特任助教 (00596158)
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2012: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
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| Keywords | 小胞体 / ストレス / ATF6 / 食事因子 / 肝臓 / 食生活 / 生活習慣病 |
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| Research Abstract |
Endoplasmic reticulum (ER ) is an organelle where secretory proteins and lipids are synthesized. We have previously reported that ER dysfunction leads to onset of lifestyle-related disease such as obesity and diabetes. In this study, we aim to elucidate the role of ATF6-mediated ER stress response on the onset of lifestyle-related disease. We studied the physiological functions of ATF6 on nutrient-regulated metabolism and the pathological function of ATF6 on nutrient-triggered lifestyle-related disease using ATF6alpha knockout mice and ATF6beta knockout mice. Although ATF6beta knockout did not affect ER protein homeostasis, we found that ATF6beta knockout showed resistant against diet-induced obesity.
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