Study of molecular pathogenesis of myelodysplastic syndromes based on transcriptome analysis

Research Project

Project/Area Number	24700970
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Multi-year Fund
Research Field	Tumor biology
Research Institution	The University of Tokyo
Principal Investigator	SATO Aiko 東京大学, 医学部附属病院, 特任研究員 (70512573)
Project Period (FY)	2012 – 2013
Project Status	Completed (Fiscal Year 2013)
Budget Amount *help	¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000) Fiscal Year 2013: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000) Fiscal Year 2012: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Keywords	トランスクリプトーム / スプライシング / 骨髄異形成症候群
Research Abstract	Frequent pathway mutation of RNA splicing machinery was reported recently. We comprehensively analyzed the aberrant RNA caused by the mutation using transcriptome analysis with next generation sequencing. Abnormally spliced transcripts were globally identified by the experiment of cell lines in which mutant genes were expressed. The wide-ranging abnormality of RNA was observed in each mutant. Further analysis of multiple MDS specimens will reveal the specific genes and pathways that explain the molecular pathogenesis of MDS.

Report

(3 results)