Analysis of antisense RNA and development of new diagnostics of gastrointestinal cancer using blood.
| Project/Area Number |
24701001
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Tumor diagnosis
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| Research Institution | University of Tsukuba |
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Principal Investigator |
KOHNO Keisuke 筑波大学, 医学医療系, 講師 (70615038)
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2012: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | 腫瘍診断学 / アンチセンスRNA / 消化器癌 / 機能性RNA / ハイスループットスクリーニング法 / バイオマーカー / アンチセンス RNA / エクソソーム / miRNA / 大腸癌 / スクリーニング / 癌 |
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| Research Abstract |
The aim of this research is to analyze of antisense RNA and develop of new diagnostics of gastrointestinal cancer using blood.
We identified 20 anti-sense RNA that is changing with the healthy people in the blood of patients with colorectal cancer. These antisenseRNA was possible to clearly distinguish the healthy people and colon cancer patients. We also identified 15 miRNA and 17 miRNA, respectively, changing to healthy people in the blood of exosomes in patients with colon cancer and pancreatic cancer patients. These miRNA was possible to distinguish clearly healthy people and patients with colorectal cancer.
From these results, we will develop new low cost custom microarray for diagnosis of gastrointestinal cancer.
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Report
(3 results)
Research Products
(4 results)
