Design and Synthesis of Bioactive Sugar Chain Mimics
| Project/Area Number |
24710248
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Living organism molecular science
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| Research Institution | Tokyo Institute of Technology |
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Principal Investigator |
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2013: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 糖鎖ミミック / 糖鎖 / シアル酸 / 複合糖質 / 糖化学 / ナノ粒子 / レクチン / ランタニドナノ粒子 |
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| Outline of Final Research Achievements |
Synthesis of the desirable sugar chains is very cumbersome process due to very diverse and complex structures of natural sugar chains. In this study, we attempted to construct the sugar chain mimics having a similar biofunction to natural sugar chians by following strategies. (1) To mimic the chain-like structure, we replace the interior sugar unit to the appropriate diol and synthesized sialic acid terminated trisaccharide mimic framework.(2) To mimic the glyco cluster, we constructed the sugar units multimer by introduction of the synthesized sugar units to the carrier (nanoparticle or multi functionalized small molecule).
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Report
(4 results)
Research Products
(19 results)
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[Presentation] Synthesis and Function of Sugar Coated Lanthanide Nanoparticles for Near-Infrared Photodynamic Therapy2012
Author(s)
A. Shimoyama, H. Watase, T. Ikejiri, S. Osawa, S.-i. Ogura, Y. Hagiya, K. Takahashi, K. Inoue, T. Tanaka, H. Yuasa
Organizer
26th International Carbohydrate Symposium (ICS2012)
Place of Presentation
Madrid, Spain
Related Report
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[Presentation] Synthesis of Sugar Coated Lanthanide Nanoparticles for 5-Aminolevulinic Acid Mediated Near-infrared Photodynamic Therapy2012
Author(s)
A. Shimoyama, H. Watase, Y. Liu, I. Sotokawa, S-i. Ogura, Y. Hagiya, K. Takahashi, K. Inoue, T. Tanaka, H. Yuasa
Organizer
The First International Symposium on Biofunctional Chemistry (ISBC2012)
Place of Presentation
Tokyo, Japan
Related Report
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