Geographical distribution and triazole resistant of the human pathogenic fungi Aspergillus fumigatus and related species in Japan

• Project/Area Number: 24710277
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Resource conservation science
• Research Institution: Nihon University
• Principal Investigator: HIROSE Dai 日本大学, 薬学部, 助教 (20513922)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000); Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2012: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
• Keywords: アスペルギルス症 / 環境 / 遺伝的変異 / 集団遺伝 / アゾール / 地理的分布 / 病原真菌 / 系統地理 / 薬剤耐性 / 分布

Outline of Final Research Achievements

Aspergillus fumigatus is one of the most important fungal pathogens of humans. Geographical distribution and triazole resistant of A. fumigatus and related species have been studied in Japan. The distribution of A. fumigatus depended on soil environments and latitude. There was no azole-resistant isolate of A. fumigatus from natural environments. The results of population genetical analysis suggested that Japanese A. fumigatus genotypes are genetically differentiated into two populations not correlated with geographical distance. Aspergillus fumigatus related species were broadly distributed in Japan, though the abundances of these species were much lower than one of A. fumigatus. The frequencies of azole resistance of A. fumigatus related species from natural environments were much high.

Research Products

• [Journal Article] Does farm fungicide use induce azole resistance in Aspergillus fumigatus? (2015)
  • Author(s): Rui Kano, Erina Kohata, Akira Tateishi, Somay Yamagata Murayama, Dai Hirose, Yasuko Shibata, Yasuhiro Kosuge, Hiroaki Inoue, Hiroshi Kamata, Atsuhiko Hasegawa
  • Journal Title: Medical Mycology Volume: 53 Issue: 2 Pages: 174
  • DOI: 10.1093/mmy/myu076
  • Peer Reviewed
• [Journal Article] Sphaerocreas pubescens is a member of the Mucoromycotina closely related to fungi associated with liverworts and hornworts (2014)
  • Author(s): Dai Hirose, Yousuke Degawa, Kohei Yamamoto, Akiyoshi Yamada
  • Journal Title: Mycoscience Volume: 55 Pages: 221-226
  • NAID: 40020035096
  • Peer Reviewed
• [Journal Article] Microfungi associated with a myrmecophyte Macaranga bancana (2013)
  • Author(s): Dai Hirose, Shoko Sakai, Takao Itioka, Takashi Osono
  • Journal Title: Tropics Volume: 印刷中
  • NAID: 130004843771
  • Peer Reviewed
• [Journal Article] Assessment of the fungal diversity and succession of ligninolytic endophytes in Camellia japonica leaves using clone library analysis (2013)
  • Author(s): Dai Hirose, Shunsuke Matsuoka, Takashi Osono
  • Journal Title: Mycologia Volume: 印刷中
  • Peer Reviewed
• [Journal Article] Microfungi associated with standing-dead willow seedlings planted in East Antarctica (2013)
  • Author(s): Dai Hirose, Takashi Osono, Yukiko Tanabe, Masaki Uchida, Sakae Kudoh
  • Journal Title: Polar Biology Volume: 印刷中
  • Peer Reviewed
• [Presentation] 自然環境中におけるAspergillus fumigatusの分布パターン (2015)
  • Author(s): 廣瀬大・永野惇・本庄三恵・八杉公基・工藤洋・村山そう明・加納塁・小菅康弘・田中陽子
  • Organizer: 真菌症フォーラム第16回学術集会
  • Place of Presentation: 第一ホテル東京 (東京・新橋）
  • Year and Date: 2015-02-14
• [Presentation] Aspergillus属の分子生態学－自然環境における生活様式を探る
  • Author(s): 廣瀬大
  • Organizer: 第57回日本医真菌学会総会
  • Place of Presentation: 京王プラザ
  • Invited
• [Presentation] 本邦環境中からのAspergillus fumigatus 関連種の分離とその薬剤感受性
  • Author(s): 矢口貴志, 廣瀬大, 伊藤純子, 松澤哲宏, 村山琮明
  • Organizer: 第57回日本医真菌学会総会
  • Place of Presentation: 京王プラザ
• [Presentation] 気候変動は菌類に影響を及ぼすのか？－わが国における地理的スケールでの分布研究からの考察
  • Author(s): 廣瀬大
  • Organizer: 日本地球惑星科学連合 2012年度連合大会
  • Place of Presentation: 幕張メッセ
  • Invited
• [Presentation] 目にみえない菌類のクローナルな生き方：主に病原菌を材料とした分子生態学研究に関する話題
  • Author(s): 廣瀬大
  • Organizer: 第60回日本生態学会
  • Place of Presentation: グランシップ
  • Invited
• [Book] 感染症の生態学 (2015)
  • Author(s): 廣瀬大
  • Publisher: 共立出版
• [Book] 菌類の事典 (2013)
  • Author(s): 廣瀬大
  • Publisher: 朝倉書店
• [Book] 微生物生態学への招待－森をめぐるミクロな世界 (2012)
  • Author(s): 廣瀬大
  • Total Pages: 353
  • Publisher: 京都大学学術出版会