| Project/Area Number |
24750090
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Synthetic chemistry
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| Research Institution | Osaka University |
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Principal Investigator |
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2013: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Fiscal Year 2012: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 有機合成化学 / 有機金属化学 / カップリング反応 / エノールエーテル |
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| Outline of Final Research Achievements |
The coupling reaction between enol ethers and silyl ketene acetals in the presence of gallium tribromide catalyst. In this reaction system, various types of enol ethers and silyl ketene acetals were applicable. As far as enol ethers, not only vinyl ethers but also substituted alkenyl ethers were found to be suitable substrates. The scope of silyl ketene acetals was also wide so that diallkyl-, diaryl-, and alkylarylsubstituted ones afforded the corresponding products in high yields. The observation of the reaction intermediate and kinetic study revealed that the coupling reaction proceeds via carbogallation among gallium tribromide, an enol ether, and a silyl ketene acetal.
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